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Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation1 Publication

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Active sitei256Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei304Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCORYNE:G18NG-10150-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:Cgl0588, cg0681
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001145121 – 361Alanine racemaseAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-(pyridoxal phosphate)lysine1

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi196627.cg0681.

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Helixi10 – 24Combined sources15
Beta strandi27 – 32Combined sources6
Helixi34 – 39Combined sources6
Helixi42 – 51Combined sources10
Beta strandi56 – 61Combined sources6
Helixi62 – 70Combined sources9
Beta strandi75 – 79Combined sources5
Helixi88 – 92Combined sources5
Turni93 – 95Combined sources3
Beta strandi97 – 100Combined sources4
Helixi103 – 110Combined sources8
Beta strandi117 – 123Combined sources7
Beta strandi129 – 132Combined sources4
Helixi134 – 145Combined sources12
Beta strandi150 – 156Combined sources7
Helixi170 – 186Combined sources17
Helixi199 – 204Combined sources6
Helixi206 – 208Combined sources3
Helixi217 – 220Combined sources4
Beta strandi236 – 241Combined sources6
Beta strandi244 – 247Combined sources4
Beta strandi267 – 272Combined sources6
Turni275 – 278Combined sources4
Helixi281 – 283Combined sources3
Turni284 – 286Combined sources3
Beta strandi288 – 291Combined sources4
Beta strandi294 – 300Combined sources7
Beta strandi307 – 312Combined sources6
Beta strandi323 – 328Combined sources6
Helixi334 – 340Combined sources7
Helixi345 – 350Combined sources6
Beta strandi357 – 361Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DY3X-ray2.10A/B/C/D1-361[»]
ProteinModelPortaliQ8RSU9.
SMRiQ8RSU9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8RSU9.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiHGVSYGH.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RSU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLTTKIDL DAIAHNTRVL KQMAGPAKLM AVVKANAYNH GVEKVAPVIA
60 70 80 90 100
AHGADAFGVA TLAEAMQLRD IGISQEVLCW IWTPEQDFRA AIDRNIDLAV
110 120 130 140 150
ISPAHAKALI ETDAEHIRVS IKIDSGLHRS GVDEQEWEGV FSALAAAPHI
160 170 180 190 200
EVTGMFTHLA CADEPENPET DRQIIAFRRA LALARKHGLE CPVNHVCNSP
210 220 230 240 250
AFLTRSDLHM EMVRPGLAFY GLEPVAGLEH GLKPAMTWEA KVSVVKQIEA
260 270 280 290 300
GQGTSYGLTW RAEDRGFVAV VPAGYADGMP RHAQGKFSVT IDGLDYPQVG
310 320 330 340 350
RVCMDQFVIS LGDNPHGVEA GAKAVIFGEN GHDATDFAER LDTINYEVVC
360
RPTGRTVRAY V
Length:361
Mass (Da):39,174
Last modified:June 1, 2002 - v1
Checksum:i6E95CAF6456B6037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY077456 Genomic DNA. Translation: AAL77207.1.
BA000036 Genomic DNA. Translation: BAB97981.1.
BX927149 Genomic DNA. Translation: CAF19293.1.
RefSeqiNP_599824.1. NC_003450.3.
WP_011013748.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB97981; BAB97981; BAB97981.
CAF19293; CAF19293; cg0681.
GeneIDi1018592.
KEGGicgb:cg0681.
cgl:NCgl0563.
PATRICi21493226. VBICorGlu203724_0579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY077456 Genomic DNA. Translation: AAL77207.1.
BA000036 Genomic DNA. Translation: BAB97981.1.
BX927149 Genomic DNA. Translation: CAF19293.1.
RefSeqiNP_599824.1. NC_003450.3.
WP_011013748.1. NC_006958.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DY3X-ray2.10A/B/C/D1-361[»]
ProteinModelPortaliQ8RSU9.
SMRiQ8RSU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196627.cg0681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB97981; BAB97981; BAB97981.
CAF19293; CAF19293; cg0681.
GeneIDi1018592.
KEGGicgb:cg0681.
cgl:NCgl0563.
PATRICi21493226. VBICorGlu203724_0579.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiHGVSYGH.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCORYNE:G18NG-10150-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8RSU9.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALR_CORGL
AccessioniPrimary (citable) accession number: Q8RSU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.