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Q8RQN6

- ACEA_COREF

UniProt

Q8RQN6 - ACEA_COREF

Protein

Isocitrate lyase

Gene

aceA

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway By similarity.By similarity

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Cofactori

    Divalent cations. Magnesium, manganese and cobalt can be used By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei193 – 1931Curated

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:aceA
    Ordered Locus Names:CE2232
    OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
    Taxonomic identifieri196164 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000001409: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 431430Isocitrate lyasePRO_0000068772Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi196164.CE2232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RQN6.
    SMRiQ8RQN6. Positions 2-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000238475.
    KOiK01637.
    OMAiKEWWASP.
    OrthoDBiEOG689HMX.

    Family and domain databases

    Gene3Di3.20.20.60. 1 hit.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 2 hits.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8RQN6-1 [UniParc]FASTAAdd to Basket

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    MSNVGTPRTA QEIQQDWDTN PRWNGITRDY TAEQVAELQG SVVEEHTLAK    50
    RGAEILWDAV SAEGDDYINA LGALTGNQAV QQVRAGLKAV YLSGWQVAGD 100
    ANLAGHTYPD QSLYPANSVP NVVRRINNAL LRADEIARVE GDTSVDNWLV 150
    PIVADGEAGF GGALNVYELQ KGMITAGAAG THWEDQLASE KKCGHLGGKV 200
    LIPTQQHIRT LNSARLAADV ANTPTVVIAR TDAEAATLIT SDVDERDRPF 250
    ITGERTAEGY YHVKPGLEPC IARAKSYAPY ADMIWMETGT PDLELAKKFA 300
    EGVRSEFPDQ LLSYNCSPSF NWSAHLEADE IAKFQKELGA MGFKFQFITL 350
    AGFHSLNYGM FDLAYGYARE GMPAFVDLQN REFKAAEERG FTAVKHQREV 400
    GAGYFDTIAT TVDPNSSTTA LKGSTEEGQF H 431
    Length:431
    Mass (Da):47,031
    Last modified:January 23, 2007 - v4
    Checksum:iA6ACDA9530A6B207
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti428 – 4281G → C in BAB88666. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083050 Genomic DNA. Translation: BAB88666.1.
    BA000035 Genomic DNA. Translation: BAC19042.1.
    RefSeqiNP_738842.1. NC_004369.1.
    WP_006768237.1. NZ_GG700683.1.

    Genome annotation databases

    EnsemblBacteriaiBAC19042; BAC19042; BAC19042.
    GeneIDi1032083.
    KEGGicef:CE2232.
    PATRICi21490593. VBICorEff9312_2208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083050 Genomic DNA. Translation: BAB88666.1 .
    BA000035 Genomic DNA. Translation: BAC19042.1 .
    RefSeqi NP_738842.1. NC_004369.1.
    WP_006768237.1. NZ_GG700683.1.

    3D structure databases

    ProteinModelPortali Q8RQN6.
    SMRi Q8RQN6. Positions 2-430.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196164.CE2232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC19042 ; BAC19042 ; BAC19042 .
    GeneIDi 1032083.
    KEGGi cef:CE2232.
    PATRICi 21490593. VBICorEff9312_2208.

    Phylogenomic databases

    HOGENOMi HOG000238475.
    KOi K01637.
    OMAi KEWWASP.
    OrthoDBi EOG689HMX.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 1 hit.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 2 hits.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "aceA of Corynebacterium efficiens."
      Hirano S., Kimura E., Kawahara Y., Sugimoto S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.
    2. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
      Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
      Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

    Entry informationi

    Entry nameiACEA_COREF
    AccessioniPrimary (citable) accession number: Q8RQN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3