Reviewed,
UniProtKB/Swiss-Prot Q8RQL9 (IDH_COREF)
Last modified
February 9, 2010.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Isocitrate dehydrogenase [NADP] Short name=IDH EC=1.1.1.42 Alternative name(s): Oxalosuccinate decarboxylase | ||||
| Gene names |
| ||||
| Organism | Corynebacterium efficiens [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 152794 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium |
Protein attributes
| Sequence length | 729 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. Oxalosuccinate + NADP+ = 2-oxoglutarate + CO2 + NADPH. |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Enzyme regulation | Weakly inhibited by oxaloacetate, 2-oxoglutarate, and citrate. Severely inhibited by oxaloacetate plus glyoxylate By similarity. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the monomeric-type IDH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glyoxylate bypass Tricarboxylic acid cycle |
| Ligand | Magnesium Metal-binding NADP |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 729 | 729 | Isocitrate dehydrogenase [NADP] | PRO_0000083594 | |||||
Regions | |||||||||
| Nucleotide binding | 80 – 85 | 6 | NADP By similarity | ||||||
| Nucleotide binding | 571 – 572 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 587 – 589 | 3 | NADP By similarity | ||||||
| Region | 121 – 128 | 8 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 337 | 1 | Magnesium or manganese By similarity | ||||||
| Metal binding | 535 | 1 | Magnesium or manganese By similarity | ||||||
| Binding site | 124 | 1 | NADP By similarity | ||||||
| Binding site | 134 | 1 | Substrate By similarity | ||||||
| Binding site | 534 | 1 | Substrate By similarity | ||||||
| Binding site | 576 | 1 | NADP By similarity | ||||||
| Binding site | 636 | 1 | NADP By similarity | ||||||
| Site | 244 | 1 | Critical for catalysis By similarity | ||||||
| Site | 407 | 1 | Critical for catalysis By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Corynebacterium efficiens icd gene for isocitrate dehydrogenase, complete cds." Nonaka G., Kimura E., Kawahara Y., Sugimoto S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395. |
| [2] | "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB083179 Genomic DNA. Translation: BAB88832.1. BA000035 Genomic DNA. Translation: BAC17492.1. Different initiation. |
| RefSeq | NP_737292.1. |
3D structure databases | |
| SMR | Q8RQL9. Positions 2-727. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1033167. |
| GenomeReviews | Gene locus CE0682 in contig BA000035_GR. |
| KEGG | cef:CE0682. |
| NMPDR | fig|196164.1.peg.682. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG286619. |
Enzyme and pathway databases | |
| BioCyc | CEFF196164:CE0682-MONOMER. |
| BRENDA | 1.1.1.42. 277326. |
Family and domain databases | |
| InterPro | IPR004436. Isocitrate_DH_NADP_mono. [Graphical view] |
| Pfam | PF03971. IDH. 1 hit. [Graphical view] |
| PIRSF | PIRSF009407. IDH_monmr. 1 hit. |
| TIGRFAMs | TIGR00178. monomer_idh. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | IDH_COREF | ||||||||
| Accession | Primary (citable) accession number: Q8RQL9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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