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Q8RQL9

- IDH_COREF

UniProt

Q8RQL9 - IDH_COREF

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, CE0682
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Enzyme regulationi

Weakly inhibited by oxaloacetate, 2-oxoglutarate, and citrate. Severely inhibited by oxaloacetate plus glyoxylate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241NADP By similarity
Binding sitei134 – 1341Substrate By similarity
Sitei244 – 2441Critical for catalysis By similarity
Metal bindingi337 – 3371Magnesium or manganese By similarity
Sitei407 – 4071Critical for catalysis By similarity
Binding sitei534 – 5341Substrate By similarity
Metal bindingi535 – 5351Magnesium or manganese By similarity
Metal bindingi539 – 5391Magnesium or manganese By similarity
Binding sitei576 – 5761NADP By similarity
Binding sitei636 – 6361NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 856NADP By similarity
Nucleotide bindingi571 – 5722NADP By similarity
Nucleotide bindingi587 – 5893NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:CE0682
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Isocitrate dehydrogenase [NADP]PRO_0000083594Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi196164.CE0682.

Structurei

3D structure databases

ProteinModelPortaliQ8RQL9.
SMRiQ8RQL9. Positions 2-727.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni121 – 1288Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RQL9-1 [UniParc]FASTAAdd to Basket

« Hide

MAKIIWTRTD EAPLLATYSL KPVVEAFAAT AGIEVETRDI SLAGRILAQF    50
ADQLPEEQKV SDALAELGEL AKTPEANIIK LPNISASVPQ LKAAVKELQE 100
QGYDLPEYED AKDRYAAVIG SNVNPVLREG NSDRRAPVAV KNFVKKFPHR 150
MGEWSADSKT NVATMGADDF RSNEKSVIMD EADTVVIKHV AADGTETVLK 200
DSLPLLKGEV IDGTFISAKA LDAFLLDQVK RAKEEGILFS AHMKATMMKV 250
SDPIIFGHIV RAYFADVYAQ YGEQLLAAGL NGENGLAAIY AGLDKLDNGA 300
EIKAAFDKGL EEGPDLAMVN SAKGITNLHV PSDVIIDASM PAMIRTSGKM 350
WNKDDQTQDA LAVIPDSSYA GVYQTVIEDC RKNGAFDPTT MGTVPNVGLM 400
AQKAEEYGSH DKTFRIEADG KVQVVASNGD VLIEHDVEKG DIWRACQTKD 450
APIQDWVKLA VNRARLSGMP AVFWLDPARA HDRNLTTLVE KYLADHDTEG 500
LDIQILSPVE ATQHAIDRIR RGEDTISVTG NVLRDYNTDL FPILELGTSA 550
KMLSVVPLMA GGGLFETGAG GSAPKHVQQV IEENHLRWDS LGEFLALAES 600
FRHELNTRNN TKAGVLADAL DRATEKLLNE EKSPSRKVGE IDNRGSHFWL 650
ATYWADELAN QTEDAELAET FAPVAEALNN QAADIDAALI GEQGKPVDLG 700
GYYAPSDEKT SAIMRPVAAF NEIIDSLKK 729
Length:729
Mass (Da):79,285
Last modified:June 1, 2002 - v1
Checksum:i84BCDECA8687627B
GO

Sequence cautioni

The sequence BAC17492.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083179 Genomic DNA. Translation: BAB88832.1.
BA000035 Genomic DNA. Translation: BAC17492.1. Different initiation.
RefSeqiNP_737292.1. NC_004369.1.
WP_006769639.1. NZ_GG700687.1.

Genome annotation databases

EnsemblBacteriaiBAC17492; BAC17492; BAC17492.
GeneIDi1033167.
KEGGicef:CE0682.
PATRICi21487524. VBICorEff9312_0704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083179 Genomic DNA. Translation: BAB88832.1 .
BA000035 Genomic DNA. Translation: BAC17492.1 . Different initiation.
RefSeqi NP_737292.1. NC_004369.1.
WP_006769639.1. NZ_GG700687.1.

3D structure databases

ProteinModelPortali Q8RQL9.
SMRi Q8RQL9. Positions 2-727.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE0682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC17492 ; BAC17492 ; BAC17492 .
GeneIDi 1033167.
KEGGi cef:CE0682.
PATRICi 21487524. VBICorEff9312_0704.

Phylogenomic databases

HOGENOMi HOG000240860.
KOi K00031.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci CEFF196164:GJW8-695-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Corynebacterium efficiens icd gene for isocitrate dehydrogenase, complete cds."
    Nonaka G., Kimura E., Kawahara Y., Sugimoto S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.
  2. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiIDH_COREF
AccessioniPrimary (citable) accession number: Q8RQL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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