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Q8RQL9

- IDH_COREF

UniProt

Q8RQL9 - IDH_COREF

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Enzyme regulationi

    Weakly inhibited by oxaloacetate, 2-oxoglutarate, and citrate. Severely inhibited by oxaloacetate plus glyoxylate By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241NADPBy similarity
    Binding sitei134 – 1341SubstrateBy similarity
    Sitei244 – 2441Critical for catalysisBy similarity
    Metal bindingi337 – 3371Magnesium or manganeseBy similarity
    Sitei407 – 4071Critical for catalysisBy similarity
    Binding sitei534 – 5341SubstrateBy similarity
    Metal bindingi535 – 5351Magnesium or manganeseBy similarity
    Metal bindingi539 – 5391Magnesium or manganeseBy similarity
    Binding sitei576 – 5761NADPBy similarity
    Binding sitei636 – 6361NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi80 – 856NADPBy similarity
    Nucleotide bindingi571 – 5722NADPBy similarity
    Nucleotide bindingi587 – 5893NADPBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciCEFF196164:GJW8-695-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:CE0682
    OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
    Taxonomic identifieri196164 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000001409: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Isocitrate dehydrogenase [NADP]PRO_0000083594Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi196164.CE0682.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RQL9.
    SMRiQ8RQL9. Positions 2-727.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni121 – 1288Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the monomeric-type IDH family.Curated

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8RQL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIIWTRTD EAPLLATYSL KPVVEAFAAT AGIEVETRDI SLAGRILAQF    50
    ADQLPEEQKV SDALAELGEL AKTPEANIIK LPNISASVPQ LKAAVKELQE 100
    QGYDLPEYED AKDRYAAVIG SNVNPVLREG NSDRRAPVAV KNFVKKFPHR 150
    MGEWSADSKT NVATMGADDF RSNEKSVIMD EADTVVIKHV AADGTETVLK 200
    DSLPLLKGEV IDGTFISAKA LDAFLLDQVK RAKEEGILFS AHMKATMMKV 250
    SDPIIFGHIV RAYFADVYAQ YGEQLLAAGL NGENGLAAIY AGLDKLDNGA 300
    EIKAAFDKGL EEGPDLAMVN SAKGITNLHV PSDVIIDASM PAMIRTSGKM 350
    WNKDDQTQDA LAVIPDSSYA GVYQTVIEDC RKNGAFDPTT MGTVPNVGLM 400
    AQKAEEYGSH DKTFRIEADG KVQVVASNGD VLIEHDVEKG DIWRACQTKD 450
    APIQDWVKLA VNRARLSGMP AVFWLDPARA HDRNLTTLVE KYLADHDTEG 500
    LDIQILSPVE ATQHAIDRIR RGEDTISVTG NVLRDYNTDL FPILELGTSA 550
    KMLSVVPLMA GGGLFETGAG GSAPKHVQQV IEENHLRWDS LGEFLALAES 600
    FRHELNTRNN TKAGVLADAL DRATEKLLNE EKSPSRKVGE IDNRGSHFWL 650
    ATYWADELAN QTEDAELAET FAPVAEALNN QAADIDAALI GEQGKPVDLG 700
    GYYAPSDEKT SAIMRPVAAF NEIIDSLKK 729
    Length:729
    Mass (Da):79,285
    Last modified:June 1, 2002 - v1
    Checksum:i84BCDECA8687627B
    GO

    Sequence cautioni

    The sequence BAC17492.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083179 Genomic DNA. Translation: BAB88832.1.
    BA000035 Genomic DNA. Translation: BAC17492.1. Different initiation.
    RefSeqiNP_737292.1. NC_004369.1.
    WP_006769639.1. NZ_GG700687.1.

    Genome annotation databases

    EnsemblBacteriaiBAC17492; BAC17492; BAC17492.
    GeneIDi1033167.
    KEGGicef:CE0682.
    PATRICi21487524. VBICorEff9312_0704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083179 Genomic DNA. Translation: BAB88832.1 .
    BA000035 Genomic DNA. Translation: BAC17492.1 . Different initiation.
    RefSeqi NP_737292.1. NC_004369.1.
    WP_006769639.1. NZ_GG700687.1.

    3D structure databases

    ProteinModelPortali Q8RQL9.
    SMRi Q8RQL9. Positions 2-727.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196164.CE0682.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC17492 ; BAC17492 ; BAC17492 .
    GeneIDi 1033167.
    KEGGi cef:CE0682.
    PATRICi 21487524. VBICorEff9312_0704.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci CEFF196164:GJW8-695-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Corynebacterium efficiens icd gene for isocitrate dehydrogenase, complete cds."
      Nonaka G., Kimura E., Kawahara Y., Sugimoto S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.
    2. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
      Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
      Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

    Entry informationi

    Entry nameiIDH_COREF
    AccessioniPrimary (citable) accession number: Q8RQL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3