ID   RPOB_THET8              Reviewed;        1119 AA.
AC   Q8RQE9; Q5SHB7;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 144.
DE   RecName: Full=DNA-directed RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            Short=RNAP subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE            EC=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=RNA polymerase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
DE   AltName: Full=Transcriptase subunit beta {ECO:0000255|HAMAP-Rule:MF_01321};
GN   Name=rpoB {ECO:0000255|HAMAP-Rule:MF_01321};
GN   OrderedLocusNames=TTHA1813;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12198314; DOI=10.1107/s0907444902011770;
RA   Vassylyeva M.N., Lee J., Sekine S.I., Laptenko O., Kuramitsu S.,
RA   Shibata T., Inoue Y., Borukhov S., Vassylyev D.G., Yokoyama S.;
RT   "Purification, crystallization and initial crystallographic analysis of RNA
RT   polymerase holoenzyme from Thermus thermophilus.";
RL   Acta Crystallogr. D 58:1497-1500(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_01321};
CC   -!- SUBUNIT: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta'
CC       and 1 omega subunit. When a sigma factor is associated with the core
CC       the holoenzyme is formed, which can initiate transcription.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000255|HAMAP-Rule:MF_01321}.
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DR   EMBL; AB083789; BAB89400.1; -; Genomic_DNA.
DR   EMBL; AP008226; BAD71636.1; -; Genomic_DNA.
DR   RefSeq; WP_011228935.1; NC_006461.1.
DR   RefSeq; YP_145079.1; NC_006461.1.
DR   PDB; 1IW7; X-ray; 2.60 A; C/M=1-1119.
DR   PDB; 1SMY; X-ray; 2.70 A; C/M=1-1119.
DR   PDB; 1ZYR; X-ray; 3.00 A; C/M=1-1119.
DR   PDB; 2A68; X-ray; 2.50 A; C/M=1-1119.
DR   PDB; 2A69; X-ray; 2.50 A; C/M=1-1119.
DR   PDB; 2A6E; X-ray; 2.80 A; C/M=1-1119.
DR   PDB; 2A6H; X-ray; 2.40 A; C/M=1-1119.
DR   PDB; 2BE5; X-ray; 2.40 A; C/M=1-1119.
DR   PDB; 2CW0; X-ray; 3.30 A; C/M=1-1119.
DR   PDB; 2O5I; X-ray; 2.50 A; C/M=1-1119.
DR   PDB; 2O5J; X-ray; 3.00 A; C/M=1-1119.
DR   PDB; 2PPB; X-ray; 3.00 A; C/M=1-1119.
DR   PDB; 3AOH; X-ray; 4.10 A; C/H/M=1-1119.
DR   PDB; 3AOI; X-ray; 4.30 A; C/H/M=1-1119.
DR   PDB; 3DXJ; X-ray; 3.00 A; C/M=1-1119.
DR   PDB; 3EQL; X-ray; 2.70 A; C/M=1-1119.
DR   PDB; 3WOD; X-ray; 3.60 A; C=1-1119.
DR   PDB; 3WOE; X-ray; 2.35 A; A/C=703-830.
DR   PDB; 3WOF; X-ray; 3.30 A; A/C/E/G/I/K/M/O/Q/S/U/W=703-830.
DR   PDB; 4G7H; X-ray; 2.90 A; C/M=1-1119.
DR   PDB; 4G7O; X-ray; 2.99 A; C/M=1-1119.
DR   PDB; 4G7Z; X-ray; 3.82 A; C/M=1-1119.
DR   PDB; 4GZY; X-ray; 3.51 A; C=1-1119.
DR   PDB; 4GZZ; X-ray; 4.29 A; C=1-1119.
DR   PDB; 4MQ9; X-ray; 3.35 A; C=1-1119.
DR   PDB; 4OIN; X-ray; 2.80 A; C=1-1119.
DR   PDB; 4OIO; X-ray; 3.10 A; C=1-1119.
DR   PDB; 4OIP; X-ray; 3.40 A; C=1-1119.
DR   PDB; 4OIQ; X-ray; 3.62 A; C=1-1119.
DR   PDB; 4OIR; X-ray; 3.10 A; C=1-1119.
DR   PDB; 4Q4Z; X-ray; 2.90 A; C=1-1119.
DR   PDB; 4Q5S; X-ray; 3.00 A; C=1-1119.
DR   PDB; 4WQS; X-ray; 4.31 A; C/M=1-1119.
DR   PDB; 4WQT; X-ray; 4.40 A; C/H/M=1-1119.
DR   PDB; 5D4C; X-ray; 3.28 A; C/M=1-1119.
DR   PDB; 5D4D; X-ray; 3.00 A; C/M=1-1119.
DR   PDB; 5D4E; X-ray; 3.08 A; C/M=1-1119.
DR   PDB; 5E17; X-ray; 3.20 A; C=1-1119.
DR   PDB; 5E18; X-ray; 3.30 A; C=1-1119.
DR   PDB; 5I2D; X-ray; 4.41 A; C/N=1-1119.
DR   PDB; 5TMC; X-ray; 2.71 A; C=1-1119.
DR   PDB; 5TMF; X-ray; 3.00 A; C=1-1119.
DR   PDB; 5VO8; X-ray; 3.30 A; C=1-1119.
DR   PDB; 5VOI; X-ray; 2.80 A; C=1-1119.
DR   PDB; 5X21; X-ray; 3.32 A; C=1-1119.
DR   PDB; 5X22; X-ray; 3.35 A; C/M=1-1119.
DR   PDB; 5XJ0; X-ray; 4.00 A; C=1-1119.
DR   PDB; 6ASG; X-ray; 3.80 A; C=1-1119.
DR   PDB; 6CUU; X-ray; 2.99 A; C=1-1119.
DR   PDB; 6KQD; X-ray; 3.30 A; C/M=1-1119.
DR   PDB; 6KQE; X-ray; 3.30 A; C=1-1119.
DR   PDB; 6KQF; X-ray; 2.45 A; C=1-1119.
DR   PDB; 6KQG; X-ray; 2.78 A; C=1-1119.
DR   PDB; 6KQH; X-ray; 3.18 A; C=1-1119.
DR   PDB; 6KQL; X-ray; 2.89 A; C=1-1119.
DR   PDB; 6KQM; X-ray; 3.20 A; C=1-1119.
DR   PDB; 6KQN; X-ray; 3.49 A; C=1-1119.
DR   PDB; 6L74; X-ray; 3.12 A; C=1-1119.
DR   PDB; 6LTS; X-ray; 3.45 A; C=1-1119.
DR   PDB; 6M6A; EM; 5.00 A; C=1-1119.
DR   PDB; 6M6B; EM; 4.10 A; C=1-1119.
DR   PDB; 6M6C; EM; 3.10 A; C=1-1119.
DR   PDB; 6OVR; X-ray; 2.84 A; C=1-1119.
DR   PDB; 6OVY; X-ray; 3.00 A; C=1-1119.
DR   PDB; 6OW3; X-ray; 2.77 A; C=1-1119.
DR   PDB; 6OY5; X-ray; 3.10 A; C=1-1119.
DR   PDB; 6OY6; X-ray; 3.10 A; C=1-1119.
DR   PDB; 6OY7; X-ray; 3.04 A; C=1-1119.
DR   PDB; 6P70; X-ray; 3.05 A; C=1-1119.
DR   PDB; 6P71; X-ray; 2.92 A; C=1-1119.
DR   PDB; 6WOX; X-ray; 3.14 A; C=1-1119.
DR   PDB; 6WOY; X-ray; 3.00 A; C=1-1119.
DR   PDB; 7EH0; X-ray; 2.81 A; C=1-1119.
DR   PDB; 7EH1; X-ray; 2.90 A; C=1-1119.
DR   PDB; 7EH2; X-ray; 3.34 A; C/M=1-1119.
DR   PDB; 7MLB; X-ray; 3.60 A; C=1-1119.
DR   PDB; 7MLI; X-ray; 3.60 A; C=1-1119.
DR   PDB; 7MLJ; X-ray; 3.75 A; C=1-1119.
DR   PDB; 7RDQ; EM; 3.00 A; C=1-1119.
DR   PDB; 8HSG; EM; 3.20 A; I=1-1119.
DR   PDB; 8HSH; EM; 3.40 A; I=1-1119.
DR   PDB; 8HSL; EM; 5.80 A; I=1-1119.
DR   PDB; 8HSR; EM; 4.00 A; I=1-1119.
DR   PDBsum; 1IW7; -.
DR   PDBsum; 1SMY; -.
DR   PDBsum; 1ZYR; -.
DR   PDBsum; 2A68; -.
DR   PDBsum; 2A69; -.
DR   PDBsum; 2A6E; -.
DR   PDBsum; 2A6H; -.
DR   PDBsum; 2BE5; -.
DR   PDBsum; 2CW0; -.
DR   PDBsum; 2O5I; -.
DR   PDBsum; 2O5J; -.
DR   PDBsum; 2PPB; -.
DR   PDBsum; 3AOH; -.
DR   PDBsum; 3AOI; -.
DR   PDBsum; 3DXJ; -.
DR   PDBsum; 3EQL; -.
DR   PDBsum; 3WOD; -.
DR   PDBsum; 3WOE; -.
DR   PDBsum; 3WOF; -.
DR   PDBsum; 4G7H; -.
DR   PDBsum; 4G7O; -.
DR   PDBsum; 4G7Z; -.
DR   PDBsum; 4GZY; -.
DR   PDBsum; 4GZZ; -.
DR   PDBsum; 4MQ9; -.
DR   PDBsum; 4OIN; -.
DR   PDBsum; 4OIO; -.
DR   PDBsum; 4OIP; -.
DR   PDBsum; 4OIQ; -.
DR   PDBsum; 4OIR; -.
DR   PDBsum; 4Q4Z; -.
DR   PDBsum; 4Q5S; -.
DR   PDBsum; 4WQS; -.
DR   PDBsum; 4WQT; -.
DR   PDBsum; 5D4C; -.
DR   PDBsum; 5D4D; -.
DR   PDBsum; 5D4E; -.
DR   PDBsum; 5E17; -.
DR   PDBsum; 5E18; -.
DR   PDBsum; 5I2D; -.
DR   PDBsum; 5TMC; -.
DR   PDBsum; 5TMF; -.
DR   PDBsum; 5VO8; -.
DR   PDBsum; 5VOI; -.
DR   PDBsum; 5X21; -.
DR   PDBsum; 5X22; -.
DR   PDBsum; 5XJ0; -.
DR   PDBsum; 6ASG; -.
DR   PDBsum; 6CUU; -.
DR   PDBsum; 6KQD; -.
DR   PDBsum; 6KQE; -.
DR   PDBsum; 6KQF; -.
DR   PDBsum; 6KQG; -.
DR   PDBsum; 6KQH; -.
DR   PDBsum; 6KQL; -.
DR   PDBsum; 6KQM; -.
DR   PDBsum; 6KQN; -.
DR   PDBsum; 6L74; -.
DR   PDBsum; 6LTS; -.
DR   PDBsum; 6M6A; -.
DR   PDBsum; 6M6B; -.
DR   PDBsum; 6M6C; -.
DR   PDBsum; 6OVR; -.
DR   PDBsum; 6OVY; -.
DR   PDBsum; 6OW3; -.
DR   PDBsum; 6OY5; -.
DR   PDBsum; 6OY6; -.
DR   PDBsum; 6OY7; -.
DR   PDBsum; 6P70; -.
DR   PDBsum; 6P71; -.
DR   PDBsum; 6WOX; -.
DR   PDBsum; 6WOY; -.
DR   PDBsum; 7EH0; -.
DR   PDBsum; 7EH1; -.
DR   PDBsum; 7EH2; -.
DR   PDBsum; 7MLB; -.
DR   PDBsum; 7MLI; -.
DR   PDBsum; 7MLJ; -.
DR   PDBsum; 7RDQ; -.
DR   PDBsum; 8HSG; -.
DR   PDBsum; 8HSH; -.
DR   PDBsum; 8HSL; -.
DR   PDBsum; 8HSR; -.
DR   AlphaFoldDB; Q8RQE9; -.
DR   EMDB; EMD-34996; -.
DR   EMDB; EMD-34997; -.
DR   EMDB; EMD-35000; -.
DR   EMDB; EMD-35004; -.
DR   SMR; Q8RQE9; -.
DR   DIP; DIP-47011N; -.
DR   IntAct; Q8RQE9; 7.
DR   DrugBank; DB08266; Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate.
DR   DrugBank; DB08226; Myxopyronin B.
DR   DrugBank; DB04788; Tagetitoxin.
DR   EnsemblBacteria; BAD71636; BAD71636; BAD71636.
DR   GeneID; 3169736; -.
DR   KEGG; ttj:TTHA1813; -.
DR   PATRIC; fig|300852.9.peg.1784; -.
DR   eggNOG; COG0085; Bacteria.
DR   HOGENOM; CLU_000524_4_1_0; -.
DR   PhylomeDB; Q8RQE9; -.
DR   BRENDA; 2.7.7.6; 2305.
DR   EvolutionaryTrace; Q8RQE9; -.
DR   PRO; PR:Q8RQE9; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1100.10; -; 1.
DR   Gene3D; 2.30.150.10; DNA-directed RNA polymerase, beta subunit, external 1 domain; 1.
DR   Gene3D; 2.40.270.10; DNA-directed RNA polymerase, subunit 2, domain 6; 1.
DR   Gene3D; 3.90.1800.10; RNA polymerase alpha subunit dimerisation domain; 1.
DR   Gene3D; 3.90.1110.10; RNA polymerase Rpb2, domain 2; 1.
DR   HAMAP; MF_01321; RNApol_bact_RpoB; 1.
DR   InterPro; IPR042107; DNA-dir_RNA_pol_bsu_ext_1_sf.
DR   InterPro; IPR019462; DNA-dir_RNA_pol_bsu_external_1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR010243; RNA_pol_bsu_bac.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   NCBIfam; TIGR02013; rpoB; 1.
DR   PANTHER; PTHR20856; DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2; 1.
DR   PANTHER; PTHR20856:SF20; DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF10385; RNA_pol_Rpb2_45; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-directed RNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transcription; Transferase.
FT   CHAIN           1..1119
FT                   /note="DNA-directed RNA polymerase subunit beta"
FT                   /id="PRO_0000047985"
FT   STRAND          2..5
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           20..29
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           31..33
FT                   /evidence="ECO:0007829|PDB:2O5I"
FT   HELIX           36..38
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   HELIX           43..51
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          53..56
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          59..61
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          64..68
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           80..85
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          91..94
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          98..100
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          103..105
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          107..109
FT                   /evidence="ECO:0007829|PDB:2O5I"
FT   STRAND          117..119
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          123..125
FT                   /evidence="ECO:0007829|PDB:1IW7"
FT   STRAND          129..132
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          134..136
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          138..142
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          146..149
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          152..154
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   STRAND          159..162
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          166..169
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          172..177
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            178..180
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          181..191
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           193..200
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           204..212
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          213..216
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   HELIX           218..221
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           225..228
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           231..241
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          242..244
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            250..252
FT                   /evidence="ECO:0007829|PDB:6OVY"
FT   HELIX           253..257
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          259..264
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            269..271
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           274..278
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          280..284
FT                   /evidence="ECO:0007829|PDB:5TMC"
FT   TURN            287..290
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          294..296
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          297..302
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   HELIX           303..314
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          325..327
FT                   /evidence="ECO:0007829|PDB:4G7O"
FT   TURN            328..330
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          331..334
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           336..361
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          364..366
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   TURN            370..372
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           376..387
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          390..394
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           401..408
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          409..418
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          419..421
FT                   /evidence="ECO:0007829|PDB:5TMC"
FT   HELIX           425..428
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           432..434
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            435..437
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          440..443
FT                   /evidence="ECO:0007829|PDB:2O5I"
FT   STRAND          445..448
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          450..455
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          456..458
FT                   /evidence="ECO:0007829|PDB:2O5J"
FT   STRAND          460..462
FT                   /evidence="ECO:0007829|PDB:3DXJ"
FT   STRAND          463..465
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          467..475
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          478..486
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           488..493
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          494..497
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   STRAND          499..501
FT                   /evidence="ECO:0007829|PDB:2CW0"
FT   STRAND          503..508
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          511..524
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            526..528
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          531..533
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            536..539
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           542..545
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           550..552
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           555..565
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          571..573
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          578..580
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           584..590
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          594..596
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          598..606
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          608..615
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            616..618
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          619..621
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          622..624
FT                   /evidence="ECO:0007829|PDB:6OY6"
FT   STRAND          628..630
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          634..637
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   STRAND          654..657
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          661..666
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          669..675
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            680..683
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   STRAND          684..691
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           693..696
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            697..700
FT                   /evidence="ECO:0007829|PDB:6KQF"
FT   STRAND          703..713
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          727..729
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           731..734
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   HELIX           735..737
FT                   /evidence="ECO:0007829|PDB:1IW7"
FT   TURN            738..740
FT                   /evidence="ECO:0007829|PDB:1IW7"
FT   STRAND          741..743
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          754..756
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          758..761
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          762..766
FT                   /evidence="ECO:0007829|PDB:1IW7"
FT   HELIX           769..778
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          785..787
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          798..807
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   TURN            808..812
FT                   /evidence="ECO:0007829|PDB:5TMC"
FT   STRAND          819..829
FT                   /evidence="ECO:0007829|PDB:3WOE"
FT   STRAND          838..840
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          842..844
FT                   /evidence="ECO:0007829|PDB:3EQL"
FT   STRAND          846..853
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            855..857
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          862..864
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          868..870
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            874..880
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           883..896
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          899..902
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            905..907
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           911..932
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           938..948
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            949..951
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          955..957
FT                   /evidence="ECO:0007829|PDB:5TMC"
FT   HELIX           959..968
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          977..979
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          980..982
FT                   /evidence="ECO:0007829|PDB:5D4D"
FT   STRAND          987..997
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            1001..1003
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          1006..1010
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          1015..1017
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          1024..1026
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          1030..1032
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           1034..1042
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           1047..1053
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   TURN            1054..1058
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           1060..1071
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   HELIX           1083..1094
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          1098..1102
FT                   /evidence="ECO:0007829|PDB:2BE5"
FT   STRAND          1104..1106
FT                   /evidence="ECO:0007829|PDB:2A6H"
FT   STRAND          1114..1117
FT                   /evidence="ECO:0007829|PDB:2A6H"
SQ   SEQUENCE   1119 AA;  125264 MW;  C1260F31CEC6B40D CRC64;
     MEIKRFGRIR EVIPLPPLTE IQVESYRRAL QADVPPEKRE NVGIQAAFRE TFPIEEEDKG
     KGGLVLDFLE YRLGEPPFPQ DECREKDLTY QAPLYARLQL IHKDTGLIKE DEVFLGHIPL
     MTEDGSFIIN GADRVIVSQI HRSPGVYFTP DPARPGRYIA SIIPLPKRGP WIDLEVEPNG
     VVSMKVNKRK FPLVLLLRVL GYDQETLARE LGAYGELVQG LMDESVFAMR PEEALIRLFT
     LLRPGDPPKR DKAVAYVYGL IADPRRYDLG EAGRYKAEEK LGIRLSGRTL ARFEDGEFKD
     EVFLPTLRYL FALTAGVPGH EVDDIDHLGN RRIRTVGELM TDQFRVGLAR LARGVRERML
     MGSEDSLTPA KLVNSRPLEA AIREFFSRSQ LSQFKDETNP LSSLRHKRRI SALGPGGLTR
     ERAGFDVRDV HRTHYGRICP VETPEGANIG LITSLAAYAR VDELGFIRTP YRRVVGGVVT
     DEVVYMTATE EDRYTIAQAN TPLEGNRIAA ERVVARRKGE PVIVSPEEVE FMDVSPKQVF
     SVNTNLIPFL EHDDANRALM GSNMQTQAVP LIRAQAPVVM TGLEERVVRD SLAALYAEED
     GEVAKVDGNR IVVRYEDGRL VEYPLRRFYR SNQGTALDQR PRVVVGQRVR KGDLLADGPA
     SENGFLALGQ NVLVAIMPFD GYNFEDAIVI SEELLKRDFY TSIHIERYEI EARDTKLGPE
     RITRDIPHLS EAALRDLDEE GVVRIGAEVK PGDILVGRTS FKGESEPTPE ERLLRSIFGE
     KARDVKDTSL RVPPGEGGIV VRTVRLRRGD PGVELKPGVR EVVRVYVAQK RKLQVGDKLA
     NRHGNKGVVA KILPVEDMPH LPDGTPVDVI LNPLGVPSRM NLGQILETHL GLAGYFLGQR
     YISPIFDGAK EPEIKELLAQ AFEVYFGKRK GEGFGVDKRE VEVLRRAEKL GLVTPGKTPE
     EQLKELFLQG KVVLYDGRTG EPIEGPIVVG QMFIMKLYHM VEDKMHARST GPYSLITQQP
     LGGKAQFGGQ RFGEMEVWAL EAYGAAHTLQ EMLTLKSDDI EGRNAAYEAI IKGEDVPEPS
     VPESFRVLVK ELQALALDVQ TLDEKDNPVD IFEGLASKR
//