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Q8RQE7

- RPOZ_THET8

UniProt

Q8RQE7 - RPOZ_THET8

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Protein

DNA-directed RNA polymerase subunit omega

Gene
rpoZ, TTHA1561
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits By similarity.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit omega (EC:2.7.7.6)
Short name:
RNAP omega subunit
Alternative name(s):
RNA polymerase omega subunit
Transcriptase subunit omega
Gene namesi
Name:rpoZ
Ordered Locus Names:TTHA1561
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999DNA-directed RNA polymerase subunit omegaUniRule annotationPRO_0000129004Add
BLAST

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Protein-protein interaction databases

DIPiDIP-47008N.
IntActiQ8RQE7. 1 interaction.
STRINGi300852.TTHA1561.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 127
Beta strandi13 – 153
Helixi16 – 3217
Helixi35 – 373
Beta strandi42 – 443
Beta strandi49 – 524
Helixi53 – 553
Beta strandi56 – 583
Helixi61 – 688
Turni69 – 713
Beta strandi74 – 807
Helixi84 – 929

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IW7X-ray2.60E/O1-99[»]
1SMYX-ray2.70E/O1-99[»]
1ZYRX-ray3.00E/O1-99[»]
2A68X-ray2.50E/O1-99[»]
2A69X-ray2.50E/O1-99[»]
2A6EX-ray2.80E/O1-99[»]
2A6HX-ray2.40E/O1-99[»]
2BE5X-ray2.40E/O1-99[»]
2CW0X-ray3.30E/O1-99[»]
2O5IX-ray2.50E/O1-99[»]
2O5JX-ray3.00E/O1-99[»]
2PPBX-ray3.00E/O1-99[»]
3AOHX-ray4.10E/J/O1-99[»]
3AOIX-ray4.30E/J/O1-99[»]
3DXJX-ray3.00E/O1-99[»]
3EQLX-ray2.70E/O1-99[»]
3WODX-ray3.60E1-99[»]
4G7HX-ray2.90E/O1-99[»]
4G7OX-ray2.99E/O1-99[»]
4G7ZX-ray3.82E/O1-99[»]
4GZYX-ray3.51E1-99[»]
4GZZX-ray4.29E1-99[»]
4MQ9X-ray3.35E1-99[»]
4OINX-ray2.80E1-99[»]
4OIOX-ray3.10E1-99[»]
4OIPX-ray3.40E1-99[»]
4OIQX-ray3.62E1-99[»]
4OIRX-ray3.10E1-99[»]
ProteinModelPortaliQ8RQE7.
SMRiQ8RQE7. Positions 2-96.

Miscellaneous databases

EvolutionaryTraceiQ8RQE7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1758.
HOGENOMiHOG000099539.
KOiK03060.
OMAiDSKYRLS.
OrthoDBiEOG6Q5NV5.

Family and domain databases

Gene3Di3.90.940.10. 1 hit.
HAMAPiMF_00366. RNApol_bact_RpoZ.
InterProiIPR003716. DNA-dir_RNA_pol_omega.
IPR006110. Pol_omega/K/RPB6.
IPR012293. RNAP_RPB6_omega.
[Graphical view]
PfamiPF01192. RNA_pol_Rpb6. 1 hit.
[Graphical view]
SUPFAMiSSF63562. SSF63562. 1 hit.
TIGRFAMsiTIGR00690. rpoZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RQE7-1 [UniParc]FASTAAdd to Basket

« Hide

MAEPGIDKLF GMVDSKYRLT VVVAKRAQQL LRHGFKNTVL EPEERPKMQT   50
LEGLFDDPNA VTWAMKELLT GRLVFGENLV PEDRLQKEME RLYPVEREE 99
Length:99
Mass (Da):11,517
Last modified:March 29, 2005 - v2
Checksum:i1D213933B0B98965
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611V → E in BAB89402. 1 Publication
Sequence conflicti92 – 921L → I in BAB89402. 1 Publication
Sequence conflicti95 – 951V → G in BAB89402. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083791 Genomic DNA. Translation: BAB89402.1.
AP008226 Genomic DNA. Translation: BAD71384.1.
RefSeqiYP_144827.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71384; BAD71384; BAD71384.
GeneIDi3169896.
KEGGittj:TTHA1561.
PATRICi23958079. VBITheThe93045_1532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083791 Genomic DNA. Translation: BAB89402.1 .
AP008226 Genomic DNA. Translation: BAD71384.1 .
RefSeqi YP_144827.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IW7 X-ray 2.60 E/O 1-99 [» ]
1SMY X-ray 2.70 E/O 1-99 [» ]
1ZYR X-ray 3.00 E/O 1-99 [» ]
2A68 X-ray 2.50 E/O 1-99 [» ]
2A69 X-ray 2.50 E/O 1-99 [» ]
2A6E X-ray 2.80 E/O 1-99 [» ]
2A6H X-ray 2.40 E/O 1-99 [» ]
2BE5 X-ray 2.40 E/O 1-99 [» ]
2CW0 X-ray 3.30 E/O 1-99 [» ]
2O5I X-ray 2.50 E/O 1-99 [» ]
2O5J X-ray 3.00 E/O 1-99 [» ]
2PPB X-ray 3.00 E/O 1-99 [» ]
3AOH X-ray 4.10 E/J/O 1-99 [» ]
3AOI X-ray 4.30 E/J/O 1-99 [» ]
3DXJ X-ray 3.00 E/O 1-99 [» ]
3EQL X-ray 2.70 E/O 1-99 [» ]
3WOD X-ray 3.60 E 1-99 [» ]
4G7H X-ray 2.90 E/O 1-99 [» ]
4G7O X-ray 2.99 E/O 1-99 [» ]
4G7Z X-ray 3.82 E/O 1-99 [» ]
4GZY X-ray 3.51 E 1-99 [» ]
4GZZ X-ray 4.29 E 1-99 [» ]
4MQ9 X-ray 3.35 E 1-99 [» ]
4OIN X-ray 2.80 E 1-99 [» ]
4OIO X-ray 3.10 E 1-99 [» ]
4OIP X-ray 3.40 E 1-99 [» ]
4OIQ X-ray 3.62 E 1-99 [» ]
4OIR X-ray 3.10 E 1-99 [» ]
ProteinModelPortali Q8RQE7.
SMRi Q8RQE7. Positions 2-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-47008N.
IntActi Q8RQE7. 1 interaction.
STRINGi 300852.TTHA1561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71384 ; BAD71384 ; BAD71384 .
GeneIDi 3169896.
KEGGi ttj:TTHA1561.
PATRICi 23958079. VBITheThe93045_1532.

Phylogenomic databases

eggNOGi COG1758.
HOGENOMi HOG000099539.
KOi K03060.
OMAi DSKYRLS.
OrthoDBi EOG6Q5NV5.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1600-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8RQE7.

Family and domain databases

Gene3Di 3.90.940.10. 1 hit.
HAMAPi MF_00366. RNApol_bact_RpoZ.
InterProi IPR003716. DNA-dir_RNA_pol_omega.
IPR006110. Pol_omega/K/RPB6.
IPR012293. RNAP_RPB6_omega.
[Graphical view ]
Pfami PF01192. RNA_pol_Rpb6. 1 hit.
[Graphical view ]
SUPFAMi SSF63562. SSF63562. 1 hit.
TIGRFAMsi TIGR00690. rpoZ. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, crystallization and initial crystallographic analysis of RNA polymerase holoenzyme from Thermus thermophilus."
    Vassylyeva M.N., Lee J., Sekine S.I., Laptenko O., Kuramitsu S., Shibata T., Inoue Y., Borukhov S., Vassylyev D.G., Yokoyama S.
    Acta Crystallogr. D 58:1497-1500(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiRPOZ_THET8
AccessioniPrimary (citable) accession number: Q8RQE7
Secondary accession number(s): Q5SI19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 29, 2005
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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