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Protein

DNA-directed RNA polymerase subunit omega

Gene

rpoZ

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit omegaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP omega subunitUniRule annotation
Alternative name(s):
RNA polymerase omega subunitUniRule annotation
Transcriptase subunit omegaUniRule annotation
Gene namesi
Name:rpoZUniRule annotation
Ordered Locus Names:TTHA1561
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999DNA-directed RNA polymerase subunit omegaPRO_0000129004Add
BLAST

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

DIPiDIP-47008N.
IntActiQ8RQE7. 1 interaction.
STRINGi300852.TTHA1561.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 127Combined sources
Beta strandi13 – 153Combined sources
Helixi16 – 3217Combined sources
Helixi35 – 373Combined sources
Beta strandi42 – 443Combined sources
Beta strandi49 – 524Combined sources
Helixi53 – 553Combined sources
Beta strandi56 – 583Combined sources
Helixi61 – 688Combined sources
Turni69 – 713Combined sources
Beta strandi74 – 807Combined sources
Helixi84 – 929Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IW7X-ray2.60E/O1-99[»]
1SMYX-ray2.70E/O1-99[»]
1ZYRX-ray3.00E/O1-99[»]
2A68X-ray2.50E/O1-99[»]
2A69X-ray2.50E/O1-99[»]
2A6EX-ray2.80E/O1-99[»]
2A6HX-ray2.40E/O1-99[»]
2BE5X-ray2.40E/O1-99[»]
2CW0X-ray3.30E/O1-99[»]
2O5IX-ray2.50E/O1-99[»]
2O5JX-ray3.00E/O1-99[»]
2PPBX-ray3.00E/O1-99[»]
3AOHX-ray4.10E/J/O1-99[»]
3AOIX-ray4.30E/J/O1-99[»]
3DXJX-ray3.00E/O1-99[»]
3EQLX-ray2.70E/O1-99[»]
3WODX-ray3.60E1-99[»]
4G7HX-ray2.90E/O1-99[»]
4G7OX-ray2.99E/O1-99[»]
4G7ZX-ray3.82E/O1-99[»]
4GZYX-ray3.51E1-99[»]
4GZZX-ray4.29E1-99[»]
4MQ9X-ray3.35E1-99[»]
4OINX-ray2.80E1-99[»]
4OIOX-ray3.10E1-99[»]
4OIPX-ray3.40E1-99[»]
4OIQX-ray3.62E1-99[»]
4OIRX-ray3.10E1-99[»]
4Q4ZX-ray2.90E1-99[»]
4Q5SX-ray3.00E1-99[»]
4WQSX-ray4.31E/O1-99[»]
4WQTX-ray4.40E/J/O1-99[»]
5E17X-ray3.20E1-99[»]
5E18X-ray3.30E1-99[»]
5I2DX-ray4.41E/P1-99[»]
ProteinModelPortaliQ8RQE7.
SMRiQ8RQE7. Positions 2-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8RQE7.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase subunit omega family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41079SJ. Bacteria.
COG1758. LUCA.
HOGENOMiHOG000099539.
KOiK03060.
OMAiEQRVRTH.

Family and domain databases

Gene3Di3.90.940.10. 1 hit.
HAMAPiMF_00366. RNApol_bact_RpoZ. 1 hit.
InterProiIPR003716. DNA-dir_RNA_pol_omega.
IPR006110. Pol_omega/K/RPB6.
IPR012293. RNAP_RPB6_omega.
[Graphical view]
PfamiPF01192. RNA_pol_Rpb6. 1 hit.
[Graphical view]
SMARTiSM01409. RNA_pol_Rpb6. 1 hit.
[Graphical view]
SUPFAMiSSF63562. SSF63562. 1 hit.
TIGRFAMsiTIGR00690. rpoZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RQE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPGIDKLF GMVDSKYRLT VVVAKRAQQL LRHGFKNTVL EPEERPKMQT
60 70 80 90
LEGLFDDPNA VTWAMKELLT GRLVFGENLV PEDRLQKEME RLYPVEREE
Length:99
Mass (Da):11,517
Last modified:March 29, 2005 - v2
Checksum:i1D213933B0B98965
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611V → E in BAB89402 (PubMed:12198314).Curated
Sequence conflicti92 – 921L → I in BAB89402 (PubMed:12198314).Curated
Sequence conflicti95 – 951V → G in BAB89402 (PubMed:12198314).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083791 Genomic DNA. Translation: BAB89402.1.
AP008226 Genomic DNA. Translation: BAD71384.1.
RefSeqiWP_008633185.1. NC_006461.1.
YP_144827.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71384; BAD71384; BAD71384.
GeneIDi3169896.
KEGGittj:TTHA1561.
PATRICi23958079. VBITheThe93045_1532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083791 Genomic DNA. Translation: BAB89402.1.
AP008226 Genomic DNA. Translation: BAD71384.1.
RefSeqiWP_008633185.1. NC_006461.1.
YP_144827.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IW7X-ray2.60E/O1-99[»]
1SMYX-ray2.70E/O1-99[»]
1ZYRX-ray3.00E/O1-99[»]
2A68X-ray2.50E/O1-99[»]
2A69X-ray2.50E/O1-99[»]
2A6EX-ray2.80E/O1-99[»]
2A6HX-ray2.40E/O1-99[»]
2BE5X-ray2.40E/O1-99[»]
2CW0X-ray3.30E/O1-99[»]
2O5IX-ray2.50E/O1-99[»]
2O5JX-ray3.00E/O1-99[»]
2PPBX-ray3.00E/O1-99[»]
3AOHX-ray4.10E/J/O1-99[»]
3AOIX-ray4.30E/J/O1-99[»]
3DXJX-ray3.00E/O1-99[»]
3EQLX-ray2.70E/O1-99[»]
3WODX-ray3.60E1-99[»]
4G7HX-ray2.90E/O1-99[»]
4G7OX-ray2.99E/O1-99[»]
4G7ZX-ray3.82E/O1-99[»]
4GZYX-ray3.51E1-99[»]
4GZZX-ray4.29E1-99[»]
4MQ9X-ray3.35E1-99[»]
4OINX-ray2.80E1-99[»]
4OIOX-ray3.10E1-99[»]
4OIPX-ray3.40E1-99[»]
4OIQX-ray3.62E1-99[»]
4OIRX-ray3.10E1-99[»]
4Q4ZX-ray2.90E1-99[»]
4Q5SX-ray3.00E1-99[»]
4WQSX-ray4.31E/O1-99[»]
4WQTX-ray4.40E/J/O1-99[»]
5E17X-ray3.20E1-99[»]
5E18X-ray3.30E1-99[»]
5I2DX-ray4.41E/P1-99[»]
ProteinModelPortaliQ8RQE7.
SMRiQ8RQE7. Positions 2-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47008N.
IntActiQ8RQE7. 1 interaction.
STRINGi300852.TTHA1561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71384; BAD71384; BAD71384.
GeneIDi3169896.
KEGGittj:TTHA1561.
PATRICi23958079. VBITheThe93045_1532.

Phylogenomic databases

eggNOGiENOG41079SJ. Bacteria.
COG1758. LUCA.
HOGENOMiHOG000099539.
KOiK03060.
OMAiEQRVRTH.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1600-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8RQE7.

Family and domain databases

Gene3Di3.90.940.10. 1 hit.
HAMAPiMF_00366. RNApol_bact_RpoZ. 1 hit.
InterProiIPR003716. DNA-dir_RNA_pol_omega.
IPR006110. Pol_omega/K/RPB6.
IPR012293. RNAP_RPB6_omega.
[Graphical view]
PfamiPF01192. RNA_pol_Rpb6. 1 hit.
[Graphical view]
SMARTiSM01409. RNA_pol_Rpb6. 1 hit.
[Graphical view]
SUPFAMiSSF63562. SSF63562. 1 hit.
TIGRFAMsiTIGR00690. rpoZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPOZ_THET8
AccessioniPrimary (citable) accession number: Q8RQE7
Secondary accession number(s): Q5SI19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 29, 2005
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.