Q8RNP4 (TYPH_LEGPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Putative thymidine phosphorylase EC=2.4.2.4 Alternative name(s): TdRPase
Organism	Legionella pneumophila
Taxonomic identifier	446 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000059095

Sequences

	Sequence		Length	Mass (Da)
	Q8RNP4 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3903064A69DFB546	FASTA	517	55,296
	10 20 30 40 50 60 MHDSFLSANG GFVVSKKTPH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG FEVQTRIQVT 70 80 90 100 110 120 LGSRSIIATL NVVTSELLQP GEAGLSDYAW ESLHAKEGDE IQVSHPKPLE SLSYVHAKIY 130 140 150 160 170 180 GNELSFEQMK VIIDDVLSGR LSDVQISAFL AASGAGRLTR TEVMKLTKAM IDSGDRLSWP 190 200 210 220 230 240 SPLVVDKHCV GGLPGNRTTL IVVPIVASFG LMIPKTSSRA ITSPAGTADT METLAPVHLS 250 260 270 280 290 300 PQKMRQVVEQ ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH 310 320 330 340 350 360 AVIDIPVGPT AKVRNQSMAL LLKQSLEEVG NELGLVVRAL FTDGSQPVGH GIGPSLEARD 370 380 390 400 410 420 VLAVLQGLPD APNDLRERAL TLAGAALECS SKVPPGLGKS IATQLLESGQ AFKKFQAICE 430 440 450 460 470 480 AQGGMRELTK ARFTYPVVAA KEGKVSLIDN RKLAKIAKLA GAPKSKSAGI DLHAHVGESV 490 500 510 EQGEPLFTIH SESLGELHYA CDLLRDKQDI IILGENP

References

[1]	"Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth." Rankin S., Li Z., Isberg R.R. Infect. Immun. 70:3637-3648(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF480912 Genomic DNA. Translation: AAM00626.1.
3D structure databases
ProteinModelPortal	Q8RNP4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_LEGPN

Accession

Primary (citable) accession number: Q8RNP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program