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Q8RNP4

- TYPH_LEGPN

UniProt

Q8RNP4 - TYPH_LEGPN

Protein

Putative thymidine phosphorylase

Gene
N/A
Organism
Legionella pneumophila
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    OrganismiLegionella pneumophila
    Taxonomic identifieri446 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Putative thymidine phosphorylasePRO_0000059095Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RNP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_00703. Thymid_phosp_2.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RNP4-1 [UniParc]FASTAAdd to Basket

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    MHDSFLSANG GFVVSKKTPH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG    50
    FEVQTRIQVT LGSRSIIATL NVVTSELLQP GEAGLSDYAW ESLHAKEGDE 100
    IQVSHPKPLE SLSYVHAKIY GNELSFEQMK VIIDDVLSGR LSDVQISAFL 150
    AASGAGRLTR TEVMKLTKAM IDSGDRLSWP SPLVVDKHCV GGLPGNRTTL 200
    IVVPIVASFG LMIPKTSSRA ITSPAGTADT METLAPVHLS PQKMRQVVEQ 250
    ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH 300
    AVIDIPVGPT AKVRNQSMAL LLKQSLEEVG NELGLVVRAL FTDGSQPVGH 350
    GIGPSLEARD VLAVLQGLPD APNDLRERAL TLAGAALECS SKVPPGLGKS 400
    IATQLLESGQ AFKKFQAICE AQGGMRELTK ARFTYPVVAA KEGKVSLIDN 450
    RKLAKIAKLA GAPKSKSAGI DLHAHVGESV EQGEPLFTIH SESLGELHYA 500
    CDLLRDKQDI IILGENP 517
    Length:517
    Mass (Da):55,296
    Last modified:June 1, 2002 - v1
    Checksum:i3903064A69DFB546
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF480912 Genomic DNA. Translation: AAM00626.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF480912 Genomic DNA. Translation: AAM00626.1 .

    3D structure databases

    ProteinModelPortali Q8RNP4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_00703. Thymid_phosp_2.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR028579. Thym_Pase_Put.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth."
      Rankin S., Li Z., Isberg R.R.
      Infect. Immun. 70:3637-3648(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTYPH_LEGPN
    AccessioniPrimary (citable) accession number: Q8RNP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3