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Protein

Cytochrome P450 165B3

Gene

cyp165B3

Organism
Amycolatopsis orientalis (Nocardia orientalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the coupling of aromatic side chains of the heptapeptide of vancomycin.

Cofactori

Pathwayi: vancomycin biosynthesis

This protein is involved in the pathway vancomycin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway vancomycin biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi347Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00162.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 165B3 (EC:1.14.-.-)
Alternative name(s):
Vancomycin biosynthesis protein OxyB
Gene namesi
Name:cyp165B3
Synonyms:oxyB
OrganismiAmycolatopsis orientalis (Nocardia orientalis)Imported
Taxonomic identifieri31958 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaeAmycolatopsis

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522391 – 398Cytochrome P450 165B3Add BLAST398

Interactioni

Protein-protein interaction databases

DIPiDIP-61594N.

Chemistry databases

BindingDBiQ8RN04.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 11Combined sources3
Helixi20 – 23Combined sources4
Beta strandi27 – 31Combined sources5
Turni36 – 38Combined sources3
Beta strandi42 – 45Combined sources4
Helixi48 – 56Combined sources9
Turni58 – 60Combined sources3
Beta strandi61 – 63Combined sources3
Helixi88 – 90Combined sources3
Helixi95 – 103Combined sources9
Helixi104 – 107Combined sources4
Helixi109 – 133Combined sources25
Beta strandi135 – 138Combined sources4
Helixi139 – 142Combined sources4
Turni143 – 146Combined sources4
Helixi147 – 156Combined sources10
Helixi160 – 162Combined sources3
Helixi163 – 172Combined sources10
Helixi180 – 203Combined sources24
Helixi209 – 217Combined sources9
Helixi218 – 220Combined sources3
Helixi223 – 236Combined sources14
Helixi239 – 254Combined sources16
Helixi256 – 262Combined sources7
Helixi266 – 280Combined sources15
Beta strandi289 – 293Combined sources5
Beta strandi295 – 297Combined sources3
Beta strandi300 – 302Combined sources3
Beta strandi307 – 310Combined sources4
Helixi312 – 315Combined sources4
Turni319 – 321Combined sources3
Turni323 – 326Combined sources4
Helixi350 – 367Combined sources18
Beta strandi372 – 375Combined sources4
Beta strandi381 – 383Combined sources3
Beta strandi385 – 388Combined sources4
Beta strandi390 – 393Combined sources4
Beta strandi395 – 397Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LFKX-ray1.70A1-398[»]
1LG9X-ray2.00A1-398[»]
1LGFX-ray2.20A1-398[»]
ProteinModelPortaliQ8RN04.
SMRiQ8RN04.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8RN04.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RN04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDDPRPLH IRRQGLDPAD ELLAAGALTR VTIGSGADAE THWMATAHAV
60 70 80 90 100
VRQVMGDHQQ FSTRRRWDPR DEIGGKGIFR PRELVGNLMD YDPPEHTRLR
110 120 130 140 150
RKLTPGFTLR KMQRMAPYIE QIVNDRLDEM ERAGSPADLI AFVADKVPGA
160 170 180 190 200
VLCELVGVPR DDRDMFMKLC HGHLDASLSQ KRRAALGDKF SRYLLAMIAR
210 220 230 240 250
ERKEPGEGMI GAVVAEYGDD ATDEELRGFC VQVMLAGDDN ISGMIGLGVL
260 270 280 290 300
AMLRHPEQID AFRGDEQSAQ RAVDELIRYL TVPYSPTPRI AREDLTLAGQ
310 320 330 340 350
EIKKGDSVIC SLPAANRDPA LAPDVDRLDV TREPIPHVAF GHGVHHCLGA
360 370 380 390
ALARLELRTV FTELWRRFPA LRLADPAQDT EFRLTTPAYG LTELMVAW
Length:398
Mass (Da):44,367
Last modified:June 1, 2002 - v1
Checksum:iF91FEA7FB0E91783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486630 Genomic DNA. Translation: AAL90878.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486630 Genomic DNA. Translation: AAL90878.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LFKX-ray1.70A1-398[»]
1LG9X-ray2.00A1-398[»]
1LGFX-ray2.20A1-398[»]
ProteinModelPortaliQ8RN04.
SMRiQ8RN04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61594N.

Chemistry databases

BindingDBiQ8RN04.
ChEMBLiCHEMBL1075039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00162.

Miscellaneous databases

EvolutionaryTraceiQ8RN04.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC5B3_AMYOR
AccessioniPrimary (citable) accession number: Q8RN04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2002
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.