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Q8RLE0

- KITH_MYCGA

UniProt

Q8RLE0 - KITH_MYCGA

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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptorUniRule annotation
Metal bindingi150 – 1501ZincUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation
Metal bindingi191 – 1911ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMGAL710127:GC09-746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:MYCGA6630
ORF Names:MGA_0502
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000001418: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Thymidine kinasePRO_0000174993Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi233150.MGA_0502.

Structurei

3D structure databases

ProteinModelPortaliQ8RLE0.
SMRiQ8RLE0. Positions 12-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RLE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKKNAMTTT NGWIEAICGP MFAGKTDELI RKIKRYEYAD VKSLVFSPAT
60 70 80 90 100
DTRSAQEIIN SRDGRRIGSI KIKKAFEIYD YVLLHKPQLV GIDEVQFFDD
110 120 130 140 150
SIVEVIQTLA DNQINVIVAG LDRDFRGEPF GPIPKILGIA ESVIRLTAIC
160 170 180 190 200
SECGAEASRS QRLIDNQPAD YNCETILIGD TESYAPRCRH HHKVPNRPIN
210 220
DQTKNFKRAL KNNFDKIVEQ SSKD
Length:224
Mass (Da):25,259
Last modified:August 15, 2003 - v2
Checksum:i8674C04BE5741FCC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101T → S in AAL91131. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081866 Genomic DNA. Translation: AAL91131.1.
AE015450 Genomic DNA. Translation: AAP57013.2.
RefSeqiNP_853445.2. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP57013; AAP57013; MGA_0502.
GeneIDi1089922.
KEGGimga:MGA_0502.
PATRICi20009223. VBIMycGal115357_0741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081866 Genomic DNA. Translation: AAL91131.1 .
AE015450 Genomic DNA. Translation: AAP57013.2 .
RefSeqi NP_853445.2. NC_004829.2.

3D structure databases

ProteinModelPortali Q8RLE0.
SMRi Q8RLE0. Positions 12-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233150.MGA_0502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP57013 ; AAP57013 ; MGA_0502 .
GeneIDi 1089922.
KEGGi mga:MGA_0502.
PATRICi 20009223. VBIMycGal115357_0741.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.

Enzyme and pathway databases

BioCyci MGAL710127:GC09-746-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Skamrov A.V., Gol'dman M.A., Feoktistova E.S., Bibilashvili R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A5969Var.B.
  2. "The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R(low)."
    Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F., Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.
    Microbiology 149:2307-2316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: R(low / passage 15 / clone 2).

Entry informationi

Entry nameiKITH_MYCGA
AccessioniPrimary (citable) accession number: Q8RLE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 15, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3