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Protein

Thiol-activated cytolysin

Gene

tly

Organism
Clostridium tetani
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxinUniRule annotation
Biological processCytolysis, HemolysisUniRule annotation
LigandLipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol-activated cytolysinUniRule annotation
Gene namesi
Name:tlyImported
OrganismiClostridium tetaniImported
Taxonomic identifieri1513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

  • Secreted UniRule annotation
  • Host cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host membrane, Membrane, SecretedUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8RKF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 204Thiol_cytolys_CInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the thiol-activated cytolysin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane beta strandUniRule annotation

Family and domain databases

Gene3Di2.60.40.1430, 1 hit
3.90.840.10, 2 hits
InterProiView protein in InterPro
IPR035390 Thiol_cytolys_C
IPR038700 Thiol_cytolys_C_sf
IPR001869 Thiol_cytolysin
IPR036363 Thiol_cytolysin_ab_sf
IPR036359 Thiol_cytolysin_sf
PfamiView protein in Pfam
PF17440 Thiol_cytolys_C, 1 hit
PF01289 Thiol_cytolysin, 1 hit
SUPFAMiSSF56978 SSF56978, 1 hit
PROSITEiView protein in PROSITE
PS00481 THIOL_CYTOLYSINS, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8RKF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SNVAYGRTIY VKLETTSKSS HVKAAFKALI NNQDISSNAE YKDILNQSSF
60 70 80 90 100
TATVLGGGAQ EHNKIITKDF DEIRNIIKNN SVVIVPQNPR YPISYTTTFF
110 120 130 140 150
KEHSIASVNY KPGYIGNNCQ PGYTNGKIVQ DHSGGHFAQF QVTWDEVSYD
160 170 180 190 200
EKGNEIVEHK AWEGNNRDRT AHFNTKIYLK GNARNISVKI RECTGLAWEW

WRDV
Length:204
Mass (Da):23,151
Last modified:March 1, 2004 - v2
Checksum:i533508276B67CC56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei204Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276621 Genomic DNA Translation: CAC81745.2

Similar proteinsi

Entry informationi

Entry nameiQ8RKF3_CLOTA
AccessioniPrimary (citable) accession number: Q8RKF3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: March 1, 2004
Last modified: April 25, 2018
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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