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Q8RIQ3

- SYL_FUSNN

UniProt

Q8RIQ3 - SYL_FUSNN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei614 – 6141ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:FN1517
    OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
    Taxonomic identifieri190304 [NCBI]
    Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
    ProteomesiUP000002521: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_0000152018Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190304.FN1517.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RIQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi611 – 6155"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RIQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDYEFKEIE KKWQERWSKD NIFKTENQVE GKENYYVLSM LPYPSGKLHV    50
    GHARNYTIGD VISRYKRMKG YNVLQPMGWD SFGLPAENAA IQNGTHPAIW 100
    TKSNIENMRR QLKLMGFSYD WEREIASYTP EYYKWNQWLF KRMYEKGLIY 150
    KKKSLVNWCP DCQTVLANEQ VEDGMCWRHS KTHVIQKELE QWFFKITDYA 200
    DELLEGHEEI KDGWPEKVLT MQKNWIGKSF GTELKLKVVE TGEDLPIFTT 250
    RIDTIYGVSY AVVAPEHPIV EKILKDNPSI KDKVTEMKNT DIIERGAEGR 300
    EKNGIDSGWH IENPVNKEIV PLWIADYVLM NYGTGAVMGV PAHDERDFVF 350
    AGKYNLPVKQ VITSKKSDEK VQLPYIEEGV MINSGEFNGL SSKDALVKIA 400
    EYVEEKGYGK RTYKYRLKDW GISRQRYWGT PIPALYCEKC GEVLEKDENL 450
    PVLLPDDIEF SGNGNPLETS NKFKEATCPC CGGKARRDTD TMDTFVDSSW 500
    YFLRYCDPKN LNLPFSKEIV DKWTPVDQYI GGVEHAVMHL LYARFFHKVL 550
    RDLGLLSSNE PFKRLLTQGM VLGPSYYSEK ENKYLLQKAA IIKGDKAYSQ 600
    SGEELQVKVE KMSKSKNNGV DPEEMLDKYG ADTTRLFIMF AAPPEKELEW 650
    NENGLAGAYR FLTRVWRLVF ENSELVKNAN DEIDYNKLSK EDKTLLIKLN 700
    QTIKKVTDAI ENNYHFNTAI AANMELINEV QTYVSSSMNS EQAAKILGYT 750
    LKKIIIMLSP FVPHFCDEIW EELGEKGYLF NEKWPEYDEK MLSSDETTIA 800
    VQVNGKVRGS FEIAKDSEQA LVEKTALKLP NVAKHLEGMN VVKIIVIPNK 850
    IVNIVVKPQ 859
    Length:859
    Mass (Da):99,129
    Last modified:June 1, 2002 - v1
    Checksum:i1F081E6B36C46E0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009951 Genomic DNA. Translation: AAL93643.1.
    RefSeqiNP_602344.1. NC_003454.1.
    WP_011015646.1. NC_003454.1.

    Genome annotation databases

    EnsemblBacteriaiAAL93643; AAL93643; FN1517.
    GeneIDi993279.
    KEGGifnu:FN1517.
    PATRICi21948557. VBIFusNuc122357_0020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009951 Genomic DNA. Translation: AAL93643.1 .
    RefSeqi NP_602344.1. NC_003454.1.
    WP_011015646.1. NC_003454.1.

    3D structure databases

    ProteinModelPortali Q8RIQ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190304.FN1517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL93643 ; AAL93643 ; FN1517 .
    GeneIDi 993279.
    KEGGi fnu:FN1517.
    PATRICi 21948557. VBIFusNuc122357_0020.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

    Entry informationi

    Entry nameiSYL_FUSNN
    AccessioniPrimary (citable) accession number: Q8RIQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3