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Q8RIQ3

- SYL_FUSNN

UniProt

Q8RIQ3 - SYL_FUSNN

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei614 – 6141ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FN1517
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_0000152018Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190304.FN1517.

Structurei

3D structure databases

ProteinModelPortaliQ8RIQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi611 – 6155"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
InParanoidiQ8RIQ3.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RIQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDYEFKEIE KKWQERWSKD NIFKTENQVE GKENYYVLSM LPYPSGKLHV
60 70 80 90 100
GHARNYTIGD VISRYKRMKG YNVLQPMGWD SFGLPAENAA IQNGTHPAIW
110 120 130 140 150
TKSNIENMRR QLKLMGFSYD WEREIASYTP EYYKWNQWLF KRMYEKGLIY
160 170 180 190 200
KKKSLVNWCP DCQTVLANEQ VEDGMCWRHS KTHVIQKELE QWFFKITDYA
210 220 230 240 250
DELLEGHEEI KDGWPEKVLT MQKNWIGKSF GTELKLKVVE TGEDLPIFTT
260 270 280 290 300
RIDTIYGVSY AVVAPEHPIV EKILKDNPSI KDKVTEMKNT DIIERGAEGR
310 320 330 340 350
EKNGIDSGWH IENPVNKEIV PLWIADYVLM NYGTGAVMGV PAHDERDFVF
360 370 380 390 400
AGKYNLPVKQ VITSKKSDEK VQLPYIEEGV MINSGEFNGL SSKDALVKIA
410 420 430 440 450
EYVEEKGYGK RTYKYRLKDW GISRQRYWGT PIPALYCEKC GEVLEKDENL
460 470 480 490 500
PVLLPDDIEF SGNGNPLETS NKFKEATCPC CGGKARRDTD TMDTFVDSSW
510 520 530 540 550
YFLRYCDPKN LNLPFSKEIV DKWTPVDQYI GGVEHAVMHL LYARFFHKVL
560 570 580 590 600
RDLGLLSSNE PFKRLLTQGM VLGPSYYSEK ENKYLLQKAA IIKGDKAYSQ
610 620 630 640 650
SGEELQVKVE KMSKSKNNGV DPEEMLDKYG ADTTRLFIMF AAPPEKELEW
660 670 680 690 700
NENGLAGAYR FLTRVWRLVF ENSELVKNAN DEIDYNKLSK EDKTLLIKLN
710 720 730 740 750
QTIKKVTDAI ENNYHFNTAI AANMELINEV QTYVSSSMNS EQAAKILGYT
760 770 780 790 800
LKKIIIMLSP FVPHFCDEIW EELGEKGYLF NEKWPEYDEK MLSSDETTIA
810 820 830 840 850
VQVNGKVRGS FEIAKDSEQA LVEKTALKLP NVAKHLEGMN VVKIIVIPNK

IVNIVVKPQ
Length:859
Mass (Da):99,129
Last modified:June 1, 2002 - v1
Checksum:i1F081E6B36C46E0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL93643.1.
RefSeqiNP_602344.1. NC_003454.1.
WP_011015646.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL93643; AAL93643; FN1517.
GeneIDi993279.
KEGGifnu:FN1517.
PATRICi21948557. VBIFusNuc122357_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL93643.1 .
RefSeqi NP_602344.1. NC_003454.1.
WP_011015646.1. NC_003454.1.

3D structure databases

ProteinModelPortali Q8RIQ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190304.FN1517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL93643 ; AAL93643 ; FN1517 .
GeneIDi 993279.
KEGGi fnu:FN1517.
PATRICi 21948557. VBIFusNuc122357_0020.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
InParanoidi Q8RIQ3.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiSYL_FUSNN
AccessioniPrimary (citable) accession number: Q8RIQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3