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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei614ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNUC190304:G1FZS-21-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FN1517
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520181 – 859Leucine--tRNA ligaseAdd BLAST859

Proteomic databases

PRIDEiQ8RIQ3

Interactioni

Protein-protein interaction databases

STRINGi190304.FN1517

Structurei

3D structure databases

ProteinModelPortaliQ8RIQ3
SMRiQ8RIQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi611 – 615"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
InParanoidiQ8RIQ3
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RIQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDYEFKEIE KKWQERWSKD NIFKTENQVE GKENYYVLSM LPYPSGKLHV
60 70 80 90 100
GHARNYTIGD VISRYKRMKG YNVLQPMGWD SFGLPAENAA IQNGTHPAIW
110 120 130 140 150
TKSNIENMRR QLKLMGFSYD WEREIASYTP EYYKWNQWLF KRMYEKGLIY
160 170 180 190 200
KKKSLVNWCP DCQTVLANEQ VEDGMCWRHS KTHVIQKELE QWFFKITDYA
210 220 230 240 250
DELLEGHEEI KDGWPEKVLT MQKNWIGKSF GTELKLKVVE TGEDLPIFTT
260 270 280 290 300
RIDTIYGVSY AVVAPEHPIV EKILKDNPSI KDKVTEMKNT DIIERGAEGR
310 320 330 340 350
EKNGIDSGWH IENPVNKEIV PLWIADYVLM NYGTGAVMGV PAHDERDFVF
360 370 380 390 400
AGKYNLPVKQ VITSKKSDEK VQLPYIEEGV MINSGEFNGL SSKDALVKIA
410 420 430 440 450
EYVEEKGYGK RTYKYRLKDW GISRQRYWGT PIPALYCEKC GEVLEKDENL
460 470 480 490 500
PVLLPDDIEF SGNGNPLETS NKFKEATCPC CGGKARRDTD TMDTFVDSSW
510 520 530 540 550
YFLRYCDPKN LNLPFSKEIV DKWTPVDQYI GGVEHAVMHL LYARFFHKVL
560 570 580 590 600
RDLGLLSSNE PFKRLLTQGM VLGPSYYSEK ENKYLLQKAA IIKGDKAYSQ
610 620 630 640 650
SGEELQVKVE KMSKSKNNGV DPEEMLDKYG ADTTRLFIMF AAPPEKELEW
660 670 680 690 700
NENGLAGAYR FLTRVWRLVF ENSELVKNAN DEIDYNKLSK EDKTLLIKLN
710 720 730 740 750
QTIKKVTDAI ENNYHFNTAI AANMELINEV QTYVSSSMNS EQAAKILGYT
760 770 780 790 800
LKKIIIMLSP FVPHFCDEIW EELGEKGYLF NEKWPEYDEK MLSSDETTIA
810 820 830 840 850
VQVNGKVRGS FEIAKDSEQA LVEKTALKLP NVAKHLEGMN VVKIIVIPNK

IVNIVVKPQ
Length:859
Mass (Da):99,129
Last modified:June 1, 2002 - v1
Checksum:i1F081E6B36C46E0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA Translation: AAL93643.1
RefSeqiNP_602344.1, NC_003454.1
WP_011015646.1, NC_003454.1

Genome annotation databases

EnsemblBacteriaiAAL93643; AAL93643; FN1517
GeneIDi993279
KEGGifnu:FN1517
PATRICifig|190304.8.peg.20

Entry informationi

Entry nameiSYL_FUSNN
AccessioniPrimary (citable) accession number: Q8RIQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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