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Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

With S4 and S5 plays an important role in translational accuracy.UniRule annotation
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.UniRule annotation

Caution

Because the enzyme that would modify Asp-89 to 3-methylthioaspartic acid has not been found in the proteome of this organism, that modification is not predicted.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciFNUC190304:G1FZS-62-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12UniRule annotation
Gene namesi
Name:rpsLUniRule annotation
Ordered Locus Names:FN1558
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001462271 – 12230S ribosomal protein S12Add BLAST122

Proteomic databases

PRIDEiQ8RIL9

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.UniRule annotation

Protein-protein interaction databases

STRINGi190304.FN1558

Structurei

3D structure databases

ProteinModelPortaliQ8RIL9
SMRiQ8RIL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS12 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UKE Bacteria
COG0048 LUCA
HOGENOMiHOG000040063
InParanoidiQ8RIL9
KOiK02950
OMAiKRGVCTA

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
HAMAPiMF_00403_B Ribosomal_S12_B, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RIL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLSQLVKK GRQTLTEKKK SPALQGNPQR RGVCIRVYTT TPKKPNSALR
60 70 80 90 100
KVARVKLTNG IEVTCYIPGE GHNLQEHSIV LVRGGRTKDL PGVRYKIIRG
110 120
ALDTAGVAKR KQGRSKYGAK NA
Length:122
Mass (Da):13,404
Last modified:June 1, 2002 - v1
Checksum:i28B59C8EE80A0344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA Translation: AAL93684.1
RefSeqiNP_602385.1, NC_003454.1
WP_005894529.1, NC_003454.1

Genome annotation databases

EnsemblBacteriaiAAL93684; AAL93684; FN1558
GeneIDi35834714
992715
KEGGifnu:FN1558
PATRICifig|190304.8.peg.61

Similar proteinsi

Entry informationi

Entry nameiRS12_FUSNN
AccessioniPrimary (citable) accession number: Q8RIL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health