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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:FN1702
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei43 – 63HelicalUniRule annotationAdd BLAST21
Transmembranei81 – 101HelicalUniRule annotationAdd BLAST21
Transmembranei109 – 129HelicalUniRule annotationAdd BLAST21
Transmembranei159 – 179HelicalUniRule annotationAdd BLAST21
Transmembranei183 – 203HelicalUniRule annotationAdd BLAST21
Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511521 – 266Undecaprenyl-diphosphataseAdd BLAST266

Interactioni

Protein-protein interaction databases

STRINGi190304.FN1702.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
InParanoidiQ8RIA6.
KOiK06153.
OMAiKVFDIAI.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RIA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVILAIVEG ITEFLPISST GHMILVNKLI GGEYLSPTFR NSFLIIIQLG
60 70 80 90 100
AIFSVVVYFW KDISPFVKTK KEFVLKFRLW LKIIVGVLPA MVIGLLLDDI
110 120 130 140 150
IDKYFLDNVL IVAITLIAYG VIFIGIEVVY KLKNIKPKVK RFAGLKYRTA
160 170 180 190 200
FLIGFFQCLA MIPGTSRSGA TIIGALLLGL SRPLAAEFSF YLAIPTMFGA
210 220 230 240 250
TALKLFKNGL AFTEMEWSYL ALGSAIAFVV AYIVIKWFMD FIKKRSFASF
260
GLYRIILGII VIVLLY
Length:266
Mass (Da):29,766
Last modified:June 1, 2002 - v1
Checksum:iBBFE32F652621967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL93817.1.
RefSeqiNP_602518.1. NC_003454.1.
WP_011015771.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL93817; AAL93817; FN1702.
GeneIDi992718.
KEGGifnu:FN1702.
PATRICi21948923. VBIFusNuc122357_0192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL93817.1.
RefSeqiNP_602518.1. NC_003454.1.
WP_011015771.1. NC_003454.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190304.FN1702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL93817; AAL93817; FN1702.
GeneIDi992718.
KEGGifnu:FN1702.
PATRICi21948923. VBIFusNuc122357_0192.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218356.
InParanoidiQ8RIA6.
KOiK06153.
OMAiKVFDIAI.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_FUSNN
AccessioniPrimary (citable) accession number: Q8RIA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.