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Q8RI83

- PCP_FUSNN

UniProt

Q8RI83 - PCP_FUSNN

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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791UniRule annotation
Active sitei142 – 1421UniRule annotation
Active sitei166 – 1661UniRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:FN1728
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Pyrrolidone-carboxylate peptidasePRO_0000184719Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi190304.FN1728.

Structurei

3D structure databases

ProteinModelPortaliQ8RI83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
InParanoidiQ8RI83.
KOiK01304.
OMAiKPNTPSM.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RI83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKILVTGFD PFGGEKINPA LEVIKLLPKK IGENEIKILE IPTVYKKSIE
60 70 80 90 100
KIDKEIESYD PDYILSIGQA GGRTDISIER IAINIDDFRI KDNEGNQPID
110 120 130 140 150
EKIYLDGDNA YFSTLPIKAI QSEITKNGIP ASISNTAGTF VCNHVFYGVR
160 170 180 190 200
YLIEKKYKGK KSGFIHIPYL PEQIIGKADT PSMSLDNILK GITIAIEIIF
210
SVENDIKKLG GSIC
Length:214
Mass (Da):23,795
Last modified:June 1, 2002 - v1
Checksum:iC006D615FC74D12F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL93843.1.
RefSeqiNP_602544.1. NC_003454.1.
WP_011015794.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL93843; AAL93843; FN1728.
GeneIDi992690.
KEGGifnu:FN1728.
PATRICi21948973. VBIFusNuc122357_0217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL93843.1 .
RefSeqi NP_602544.1. NC_003454.1.
WP_011015794.1. NC_003454.1.

3D structure databases

ProteinModelPortali Q8RI83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190304.FN1728.

Protein family/group databases

MEROPSi C15.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL93843 ; AAL93843 ; FN1728 .
GeneIDi 992690.
KEGGi fnu:FN1728.
PATRICi 21948973. VBIFusNuc122357_0217.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
InParanoidi Q8RI83.
KOi K01304.
OMAi KPNTPSM.
OrthoDBi EOG6X1124.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
TIGRFAMsi TIGR00504. pyro_pdase. 1 hit.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiPCP_FUSNN
AccessioniPrimary (citable) accession number: Q8RI83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3