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Reviewed, UniProtKB/Swiss-Prot Q8RHJ2 (HPPA_FUSNN)

Last modified February 9, 2010. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pyrophosphate-energized proton pump
    EC=3.6.1.1
Alternative name(s):
    Pyrophosphate-energized inorganic pyrophosphatase
      Short name=H(+)-PPase
    Membrane-bound proton-translocating pyrophosphatase
Gene names
Name: hppA
Ordered Locus Names: FN2030
OrganismFusobacterium nucleatum subsp. nucleatum [Complete proteome] [HAMAP]
Taxonomic identifier76856 [NCBI]
Taxonomic lineageBacteria › Fusobacteria › Fusobacterales › Fusobacteriaceae › Fusobacterium

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Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Generates a proton motive force; it probably catalyzes a fully reversible reaction, thus being able to synthesize pyrophosphate when the proton motive force is sufficient By similarity. HAMAP MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01129

Cofactor

Magnesium By similarity. HAMAP MF_01129

Potassium By similarity. HAMAP MF_01129

Subunit structure

Homodimer Potential. HAMAP MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein Probable HAMAP MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. Type 1 subfamily. [View classification]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 671671Pyrophosphate-energized proton pump HAMAP MF_01129
PRO_0000217003

Regions

Transmembrane4 – 2623 Potential
Transmembrane60 – 9435 Potential
Transmembrane126 – 14823 Potential
Transmembrane161 – 18323 Potential
Transmembrane225 – 24723 Potential
Transmembrane254 – 27623 Potential
Transmembrane291 – 31323 Potential
Transmembrane315 – 33723 Potential
Transmembrane361 – 38323 Potential
Transmembrane390 – 41223 Potential
Transmembrane450 – 47223 Potential
Transmembrane493 – 51523 Potential
Transmembrane560 – 57920 Potential
Transmembrane581 – 60323 Potential
Transmembrane646 – 66823 Potential

Sites

Site4501Determinant of potassium dependence By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8RHJ2-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B9519DE6D3554ACB

FASTA67168,989
        10         20         30         40         50         60 
MDLLTQVMYI GIAVGIISLL AAFYYAKKVE HYQINIPKVE EITAAIREGA MAFLAAEYKI 

        70         80         90        100        110        120 
LIVFVIVVAV ALGIFISVPT AGAFILGAIT SAIAGNAGMR IATKANGRTA IAAKEGGLAK 

       130        140        150        160        170        180 
ALNVAFSGGA VMGLTVVGLG MFMLSLILLV SRTVGISVND VTGFGMGASS IALFARVGGG 

       190        200        210        220        230        240 
IYTKAADVGA DLVGKVEAGI PEDDPRNPAT IADNVGDNVG DVAGMGADLF ESYVGSIIAT 

       250        260        270        280        290        300 
ITLAFLLPVD DATPYVAAPL LISAFGIISS IIATLTVKTD DGSKVHAKLE MGTRIAGILT 

       310        320        330        340        350        360 
IIASFGIIKY LGLDMGIFYA IVAGLVAGLV IAYFTGVYTD TGRRAVNRVS DAAGTGAATA 

       370        380        390        400        410        420 
IIEGLAIGME STVAPLIVIA IAIIISFKTG GLYGISIAAV GMLATTGMVV AVDAYGPVAD 

       430        440        450        460        470        480 
NAGGIAEMSE LPPEVRETTD KLDAVGNSTA AVGKGFAIGS AALTALSLFA AYKEAVDKLT 

       490        500        510        520        530        540 
SEALVIDVTD PEVIAGLFIG GMLTFLFSAL TMTAVGKAAI EMVEEVRRQF REFPGIMDRT 

       550        560        570        580        590        600 
QKPDYKRCVE ISTHSSLKQM ILPGVLAIIV PVIIGLWSVK ALGGLLAGAL VTGVLMAIMM 

       610        620        630        640        650        660 
ANAGGAWDNG KKQIEGGYKG DKKGSDRHKA AVVGDTVGDP FKDTSGPSLN ILIKLMSIVS 

       670 
LVLVPLFVKF M

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009951 Genomic DNA. Translation: AAL94115.1.
RefSeqNP_602816.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID992205.
GenomeReviewsGene locus FN2030 in contig AE009951_GR.
KEGGfnu:FN2030.
NMPDRfig|190304.1.peg.495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG593668.
OMAAYLARQY.

Enzyme and pathway databases

BioCycFNUC190304:FN2030-MONOMER.
BRENDA3.6.1.1. 289963.

Family and domain databases

HAMAPMF_01129. H_PPase_type1.
[Tree]
InterProIPR004131. H_PPase.
[Graphical view]
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHPPA_FUSNN
AccessionPrimary (citable) accession number: Q8RHJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents