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Q8RHJ2 (HPPA_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pump
EC=3.6.1.1
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Short name=Na(+)-PPase
Gene names
Name:hppA
Ordered Locus Names:FN2030
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteria › Fusobacteria › Fusobacterales › Fusobacteriaceae › Fusobacterium

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane By similarity. HAMAP MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01129

Cofactor

Magnesium By similarity. HAMAP MF_01129

Enzyme regulation

Requires K+ for maximal activity By similarity. HAMAP MF_01129

Subunit structure

Homodimer By similarity. HAMAP MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 671671Putative K(+)-stimulated pyrophosphate-energized sodium pump HAMAP MF_01129
PRO_0000217003

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane295 – 31521Helical; Potential
Transmembrane317 – 33721Helical; Potential
Transmembrane365 – 38521Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane450 – 47021Helical; Potential
Transmembrane493 – 51321Helical; Potential
Transmembrane559 – 57921Helical; Potential
Transmembrane581 – 60121Helical; Potential
Transmembrane651 – 67121Helical; Potential

Sites

Site4501Determinant of potassium dependence By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RHJ2 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: B9519DE6D3554ACB

FASTA67168,989
        10         20         30         40         50         60 
MDLLTQVMYI GIAVGIISLL AAFYYAKKVE HYQINIPKVE EITAAIREGA MAFLAAEYKI 

        70         80         90        100        110        120 
LIVFVIVVAV ALGIFISVPT AGAFILGAIT SAIAGNAGMR IATKANGRTA IAAKEGGLAK 

       130        140        150        160        170        180 
ALNVAFSGGA VMGLTVVGLG MFMLSLILLV SRTVGISVND VTGFGMGASS IALFARVGGG 

       190        200        210        220        230        240 
IYTKAADVGA DLVGKVEAGI PEDDPRNPAT IADNVGDNVG DVAGMGADLF ESYVGSIIAT 

       250        260        270        280        290        300 
ITLAFLLPVD DATPYVAAPL LISAFGIISS IIATLTVKTD DGSKVHAKLE MGTRIAGILT 

       310        320        330        340        350        360 
IIASFGIIKY LGLDMGIFYA IVAGLVAGLV IAYFTGVYTD TGRRAVNRVS DAAGTGAATA 

       370        380        390        400        410        420 
IIEGLAIGME STVAPLIVIA IAIIISFKTG GLYGISIAAV GMLATTGMVV AVDAYGPVAD 

       430        440        450        460        470        480 
NAGGIAEMSE LPPEVRETTD KLDAVGNSTA AVGKGFAIGS AALTALSLFA AYKEAVDKLT 

       490        500        510        520        530        540 
SEALVIDVTD PEVIAGLFIG GMLTFLFSAL TMTAVGKAAI EMVEEVRRQF REFPGIMDRT 

       550        560        570        580        590        600 
QKPDYKRCVE ISTHSSLKQM ILPGVLAIIV PVIIGLWSVK ALGGLLAGAL VTGVLMAIMM 

       610        620        630        640        650        660 
ANAGGAWDNG KKQIEGGYKG DKKGSDRHKA AVVGDTVGDP FKDTSGPSLN ILIKLMSIVS 

       670 
LVLVPLFVKF M

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009951 Genomic DNA. Translation: AAL94115.1.
RefSeqNP_602816.1. NC_003454.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID992205.
GenomeReviewsGene locus FN2030 in contig AE009951_GR.
KEGGfnu:FN2030.
NMPDRfig|190304.1.peg.495.
PATRIC21949585. VBIFusNuc122357_0493.

Phylogenomic databases

HOGENOMHBG593668.
OMAIAEMSGL.
PhylomeDBQ8RHJ2.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycFNUC190304:FN2030-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase-energized_pump.
[Tree]
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
KOK01507.
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPA_FUSNN
AccessionPrimary (citable) accession number: Q8RHJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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