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Protein

Guanylate kinase

Gene

gmk

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNUC190304:G1FZS-520-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:FN2033
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705401 – 185Guanylate kinaseAdd BLAST185

Interactioni

Protein-protein interaction databases

STRINGi190304.FN2033

Structurei

3D structure databases

ProteinModelPortaliQ8RHI9
SMRiQ8RHI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 181Guanylate kinase-likeUniRule annotationAdd BLAST178

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037640
InParanoidiQ8RHI9
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RHI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGALYVVS GPSGAGKSTV CKLVRERLGI NLSISATSRK PRNGEQEGVD
60 70 80 90 100
YFFITAEEFE RKIKNDDFLE YANVHGNYYG TLKSEVEERL KRGEKVLLEI
110 120 130 140 150
DVQGGVQVKN KFPEANLIFF KTANKEELEK RLRGRNTDSE EVIQARLKNS
160 170 180
LKELEYESKY DRVIINNEIE QACNDLISII ENGVK
Length:185
Mass (Da):21,025
Last modified:June 1, 2002 - v1
Checksum:i988EF86443662B96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA Translation: AAL94118.1
RefSeqiNP_602819.1, NC_003454.1
WP_005904066.1, NC_003454.1

Genome annotation databases

EnsemblBacteriaiAAL94118; AAL94118; FN2033
GeneIDi992197
KEGGifnu:FN2033
PATRICifig|190304.8.peg.496

Similar proteinsi

Entry informationi

Entry nameiKGUA_FUSNN
AccessioniPrimary (citable) accession number: Q8RHI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health