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Q8RHF4

- FTHS_FUSNN

UniProt

Q8RHF4 - FTHS_FUSNN

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 708ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:FN2082
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Formate--tetrahydrofolate ligasePRO_0000199349Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190304.FN2082.

Structurei

3D structure databases

ProteinModelPortaliQ8RHF4.
SMRiQ8RHF4. Positions 3-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
InParanoidiQ8RHF4.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RHF4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDIQIAQAA KKENIVEIAK KLGLTEDDIE QYGKYKAKVN LDVLQKNKRP
60 70 80 90 100
NGKLILVTAI TPTPAGEGKS TVTIGLTQAL NKMGKLSAAA IREPSLGPVF
110 120 130 140 150
GMKGGAAGGG YAQVVPMEDI NLHFTGDMHA IGIAHNLISA CIDNHINSGN
160 170 180 190 200
ALGIDVTKIT WKRVVDMNDR ALRNIVIGLG GKANGYPRQD SFQITVGSEI
210 220 230 240 250
MAILCLSNSI TELKEKIKNI VIGTSVTGKL IKVGDFHIEG AVAALLKDAI
260 270 280 290 300
KPNLVQTLEN TPVFIHGGPF ANIAHGCNSI LATKMALKLT DYVVTEAGFA
310 320 330 340 350
ADLGAEKFID IKCRLGGLKP DCAVIVATVR ALEHHGKGDL KAGLENLDKH
360 370 380 390 400
IDNIKNKYKL PLVVAINKFI TDTDEQINMI EKFCNERGAE VSLCEVWAKG
410 420 430 440 450
GEGGIDLAEK VLKAIDNNKT EFDYFYDINL TIKEKIEKIC KEIYGADGVI
460 470 480 490 500
FAPATKKVFD VIEAEGLNKL PVCMSKTQKS ISDNPALLGK PTGFKVTIND
510 520 530 540
LRLAVGAGFV IAMAGDIIDM PGLPKKPSAE VIDIDENGVI SGLF
Length:544
Mass (Da):58,321
Last modified:June 1, 2002 - v1
Checksum:iC3CAEF3D15625B75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL94166.1.
RefSeqiNP_602867.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL94166; AAL94166; FN2082.
GeneIDi992059.
KEGGifnu:FN2082.
PATRICi21949689. VBIFusNuc122357_0544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL94166.1 .
RefSeqi NP_602867.1. NC_003454.1.

3D structure databases

ProteinModelPortali Q8RHF4.
SMRi Q8RHF4. Positions 3-542.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190304.FN2082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL94166 ; AAL94166 ; FN2082 .
GeneIDi 992059.
KEGGi fnu:FN2082.
PATRICi 21949689. VBIFusNuc122357_0544.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
InParanoidi Q8RHF4.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiFTHS_FUSNN
AccessioniPrimary (citable) accession number: Q8RHF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3