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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 708ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:FN2082
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Formate--tetrahydrofolate ligasePRO_0000199349Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190304.FN2082.

Structurei

3D structure databases

ProteinModelPortaliQ8RHF4.
SMRiQ8RHF4. Positions 3-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
InParanoidiQ8RHF4.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RHF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIQIAQAA KKENIVEIAK KLGLTEDDIE QYGKYKAKVN LDVLQKNKRP
60 70 80 90 100
NGKLILVTAI TPTPAGEGKS TVTIGLTQAL NKMGKLSAAA IREPSLGPVF
110 120 130 140 150
GMKGGAAGGG YAQVVPMEDI NLHFTGDMHA IGIAHNLISA CIDNHINSGN
160 170 180 190 200
ALGIDVTKIT WKRVVDMNDR ALRNIVIGLG GKANGYPRQD SFQITVGSEI
210 220 230 240 250
MAILCLSNSI TELKEKIKNI VIGTSVTGKL IKVGDFHIEG AVAALLKDAI
260 270 280 290 300
KPNLVQTLEN TPVFIHGGPF ANIAHGCNSI LATKMALKLT DYVVTEAGFA
310 320 330 340 350
ADLGAEKFID IKCRLGGLKP DCAVIVATVR ALEHHGKGDL KAGLENLDKH
360 370 380 390 400
IDNIKNKYKL PLVVAINKFI TDTDEQINMI EKFCNERGAE VSLCEVWAKG
410 420 430 440 450
GEGGIDLAEK VLKAIDNNKT EFDYFYDINL TIKEKIEKIC KEIYGADGVI
460 470 480 490 500
FAPATKKVFD VIEAEGLNKL PVCMSKTQKS ISDNPALLGK PTGFKVTIND
510 520 530 540
LRLAVGAGFV IAMAGDIIDM PGLPKKPSAE VIDIDENGVI SGLF
Length:544
Mass (Da):58,321
Last modified:June 1, 2002 - v1
Checksum:iC3CAEF3D15625B75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL94166.1.
RefSeqiNP_602867.1. NC_003454.1.
WP_005903107.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL94166; AAL94166; FN2082.
GeneIDi992059.
KEGGifnu:FN2082.
PATRICi21949689. VBIFusNuc122357_0544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL94166.1.
RefSeqiNP_602867.1. NC_003454.1.
WP_005903107.1. NC_003454.1.

3D structure databases

ProteinModelPortaliQ8RHF4.
SMRiQ8RHF4. Positions 3-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190304.FN2082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL94166; AAL94166; FN2082.
GeneIDi992059.
KEGGifnu:FN2082.
PATRICi21949689. VBIFusNuc122357_0544.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
InParanoidiQ8RHF4.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiFTHS_FUSNN
AccessioniPrimary (citable) accession number: Q8RHF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: May 27, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.