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Q8RHF4 (FTHS_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:FN2082
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 544544Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199349

Regions

Nucleotide binding63 – 708ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RHF4 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C3CAEF3D15625B75

FASTA54458,321
        10         20         30         40         50         60 
MTDIQIAQAA KKENIVEIAK KLGLTEDDIE QYGKYKAKVN LDVLQKNKRP NGKLILVTAI 

        70         80         90        100        110        120 
TPTPAGEGKS TVTIGLTQAL NKMGKLSAAA IREPSLGPVF GMKGGAAGGG YAQVVPMEDI 

       130        140        150        160        170        180 
NLHFTGDMHA IGIAHNLISA CIDNHINSGN ALGIDVTKIT WKRVVDMNDR ALRNIVIGLG 

       190        200        210        220        230        240 
GKANGYPRQD SFQITVGSEI MAILCLSNSI TELKEKIKNI VIGTSVTGKL IKVGDFHIEG 

       250        260        270        280        290        300 
AVAALLKDAI KPNLVQTLEN TPVFIHGGPF ANIAHGCNSI LATKMALKLT DYVVTEAGFA 

       310        320        330        340        350        360 
ADLGAEKFID IKCRLGGLKP DCAVIVATVR ALEHHGKGDL KAGLENLDKH IDNIKNKYKL 

       370        380        390        400        410        420 
PLVVAINKFI TDTDEQINMI EKFCNERGAE VSLCEVWAKG GEGGIDLAEK VLKAIDNNKT 

       430        440        450        460        470        480 
EFDYFYDINL TIKEKIEKIC KEIYGADGVI FAPATKKVFD VIEAEGLNKL PVCMSKTQKS 

       490        500        510        520        530        540 
ISDNPALLGK PTGFKVTIND LRLAVGAGFV IAMAGDIIDM PGLPKKPSAE VIDIDENGVI 


SGLF 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL94166.1.
RefSeqNP_602867.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RHF4.
SMRQ8RHF4. Positions 3-542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN2082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94166; AAL94166; FN2082.
GeneID992059.
KEGGfnu:FN2082.
PATRIC21949689. VBIFusNuc122357_0544.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_FUSNN
AccessionPrimary (citable) accession number: Q8RHF4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways