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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

FN0226

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

D-threonate 4-phosphate + NAD+ = dihydroxyacetone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Binding sitei139SubstrateBy similarity1
Metal bindingi168Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi211Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi266Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei274SubstrateBy similarity1
Binding sitei292SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Ordered Locus Names:FN0226
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001888081 – 332Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST332

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi190304.FN0226.

Structurei

3D structure databases

ProteinModelPortaliQ8RGR0.
SMRiQ8RGR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CEZ. Bacteria.
COG1995. LUCA.
HOGENOMiHOG000221593.
InParanoidiQ8RGR0.
KOiK00097.
OMAiGHLYPGH.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RGR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTKIAIPMG DPAGVGPEIV VKTAVSKEIL DLCDLVVIGD KKVLEKATKI
60 70 80 90 100
CQVDLKIHTI KNIEEGKYEK GILNVIDLEN VDMNTLEYGQ VQGMCGKAAF
110 120 130 140 150
EYIKKCVELA MEYKVDAIAT TPINKESLRA GNVNYIGHTE ILGDLSNSRD
160 170 180 190 200
PLTMFEVDNM RVFFLTRHMS LRKACDAITK ERVLEYIERC TKALKQLGVT
210 220 230 240 250
GKMAVAGLNP HSGEHGLFGN EEVKEITPAI EEAQKLGYDV VGPIGADSVF
260 270 280 290 300
HQALQGRYVA VLSLYHDQGH IATKTYDFER TIAITLDMPF LRTSVDHGTA
310 320 330
FDIAGKGIVS AISMIEAVKL AAKYAPNFKN IK
Length:332
Mass (Da):36,547
Last modified:June 1, 2002 - v1
Checksum:iA9032E3F6E7081FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL94432.1.
RefSeqiNP_603133.1. NC_003454.1.
WP_011016238.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL94432; AAL94432; FN0226.
GeneIDi993114.
KEGGifnu:FN0226.
PATRICifig|190304.8.peg.807.

Similar proteinsi

Entry informationi

Entry nameiPDXA2_FUSNN
AccessioniPrimary (citable) accession number: Q8RGR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families