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Q8RGP6 (TYSY_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:FN0240
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteria › Fusobacteria › Fusobacteriales › Fusobacteriaceae › Fusobacterium ›

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP-Rule MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000140960

Sites

Active site1581 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RGP6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: D7C717191E1FE196

FASTA27532,172
        10         20         30         40         50         60 
MKARFDKIYK DIVDTIAEKG IWSEGNVRTK YADGTAAHYK SYIGYQFRLD NSDDEAHLIT 

        70         80         90        100        110        120 
SRFAPSKAPI RELYWIWILQ SNNVDVLNEL GCKFWDEWKM QDGTIGKAYG YQIAQETFGQ 

       130        140        150        160        170        180 
KSQLHYVINE LKKNPNSRRI MTEIWIPNEL SEMALTPCVH LTQWSVIGNK LYLEVRQRSC 

       190        200        210        220        230        240 
DVALGLVANV FQYSVLHKLV ALECGLEPAE IIWNIHNMHI YDRHYDKLIE QVNRETFEPA 

       250        260        270 
KIKINNFKSI FDFKPDDIEI IDYKYGEKVS YEVAI

« Hide

References

[1]"Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586."
Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A., Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O., Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N. expand/collapse author list , D'Souza M., Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C., Overbeek R.
J. Bacteriol. 184:2005-2018(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE009951 Genomic DNA. Translation: AAL94446.1.
RefSeqNP_603147.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RGP6.
ModBaseSearch...

Protein-protein interaction databases

STRING190304.FN0240.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94446; AAL94446; FN0240.
GeneID993128.
KEGGfnu:FN0240.
PATRIC21950257. VBIFusNuc122357_0821.

Phylogenomic databases

eggNOGCOG0207.
HOGENOMHOG000257898.
KOK00560.
OMAKSWDANA.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_FUSNN
AccessionPrimary (citable) accession number: Q8RGP6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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