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Q8RGH3 (ALF1_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Ordered Locus Names:FN0322
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP-Rule MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP-Rule MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Fructose-bisphosphate aldolase class 1 HAMAP-Rule MF_00729
PRO_0000216900

Sites

Active site1761Proton acceptor By similarity
Active site2131Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RGH3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 492DA50FBAC26495

FASTA29532,896
        10         20         30         40         50         60 
MNEKLEKMRN GKGFIAALDQ SGGSTPKALK LYGVNENEYS NDKEMFDLIH KMRTRIIKSP 

        70         80         90        100        110        120 
AFNESKILGA ILFEQTMDSK IDGKYTADFL WEEKKVLPFL KIDKGLNDLD ADGVQTMKPN 

       130        140        150        160        170        180 
PTLADLLKRA NERHIFGTKM RSVIKKASPA GIARVVEQQF EVAAQVVAAG LIPIIEPEVD 

       190        200        210        220        230        240 
INNVDKVQCE EILRDEIRKH LNALPETSNV MLKLTLPTVE NLYEEFTKHP RVVRVVALSG 

       250        260        270        280        290 
GYSREKANDI LSKNKGVIAS FSRALTEGLS AQQTDEEFNK TLAASIDGIY EASVK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL94528.1.
RefSeqNP_603229.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RGH3.
SMRQ8RGH3. Positions 1-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0322.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94528; AAL94528; FN0322.
GeneID991677.
KEGGfnu:FN0322.
PATRIC21950419. VBIFusNuc122357_0902.

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000073502.
KOK01623.
OMAGTKMRSV.
OrthoDBEOG6M6JJT.
ProtClustDBPRK05377.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00729. FBP_aldolase_1.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_FUSNN
AccessionPrimary (citable) accession number: Q8RGH3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways