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Q8RGH3

- ALF1_FUSNN

UniProt

Q8RGH3 - ALF1_FUSNN

Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei176 – 1761Proton acceptorUniRule annotation
    Active sitei213 – 2131Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolaseUniRule annotation
    Gene namesi
    Name:fdaUniRule annotation
    Ordered Locus Names:FN0322
    OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
    Taxonomic identifieri190304 [NCBI]
    Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
    ProteomesiUP000002521: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Fructose-bisphosphate aldolase class 1PRO_0000216900Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190304.FN0322.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RGH3.
    SMRiQ8RGH3. Positions 1-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3588.
    HOGENOMiHOG000073502.
    KOiK01623.
    OMAiYTGDYLA.
    OrthoDBiEOG6M6JJT.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00729. FBP_aldolase_1.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RGH3-1 [UniParc]FASTAAdd to Basket

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    MNEKLEKMRN GKGFIAALDQ SGGSTPKALK LYGVNENEYS NDKEMFDLIH    50
    KMRTRIIKSP AFNESKILGA ILFEQTMDSK IDGKYTADFL WEEKKVLPFL 100
    KIDKGLNDLD ADGVQTMKPN PTLADLLKRA NERHIFGTKM RSVIKKASPA 150
    GIARVVEQQF EVAAQVVAAG LIPIIEPEVD INNVDKVQCE EILRDEIRKH 200
    LNALPETSNV MLKLTLPTVE NLYEEFTKHP RVVRVVALSG GYSREKANDI 250
    LSKNKGVIAS FSRALTEGLS AQQTDEEFNK TLAASIDGIY EASVK 295
    Length:295
    Mass (Da):32,896
    Last modified:June 1, 2002 - v1
    Checksum:i492DA50FBAC26495
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009951 Genomic DNA. Translation: AAL94528.1.
    RefSeqiNP_603229.1. NC_003454.1.

    Genome annotation databases

    EnsemblBacteriaiAAL94528; AAL94528; FN0322.
    GeneIDi991677.
    KEGGifnu:FN0322.
    PATRICi21950419. VBIFusNuc122357_0902.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009951 Genomic DNA. Translation: AAL94528.1 .
    RefSeqi NP_603229.1. NC_003454.1.

    3D structure databases

    ProteinModelPortali Q8RGH3.
    SMRi Q8RGH3. Positions 1-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190304.FN0322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL94528 ; AAL94528 ; FN0322 .
    GeneIDi 991677.
    KEGGi fnu:FN0322.
    PATRICi 21950419. VBIFusNuc122357_0902.

    Phylogenomic databases

    eggNOGi COG3588.
    HOGENOMi HOG000073502.
    KOi K01623.
    OMAi YTGDYLA.
    OrthoDBi EOG6M6JJT.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00729. FBP_aldolase_1.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    IPR023014. FBA_I_Gram+-type.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

    Entry informationi

    Entry nameiALF1_FUSNN
    AccessioniPrimary (citable) accession number: Q8RGH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3