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Q8RGH3

- ALF1_FUSNN

UniProt

Q8RGH3 - ALF1_FUSNN

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Protein

Fructose-bisphosphate aldolase class 1

Gene
fda, FN0322
Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton acceptor By similarity
Active sitei213 – 2131Schiff-base intermediate with dihydroxyacetone-P By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fda
Ordered Locus Names:FN0322
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Fructose-bisphosphate aldolase class 1UniRule annotationPRO_0000216900Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190304.FN0322.

Structurei

3D structure databases

ProteinModelPortaliQ8RGH3.
SMRiQ8RGH3. Positions 1-295.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiYTGDYLA.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RGH3-1 [UniParc]FASTAAdd to Basket

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MNEKLEKMRN GKGFIAALDQ SGGSTPKALK LYGVNENEYS NDKEMFDLIH    50
KMRTRIIKSP AFNESKILGA ILFEQTMDSK IDGKYTADFL WEEKKVLPFL 100
KIDKGLNDLD ADGVQTMKPN PTLADLLKRA NERHIFGTKM RSVIKKASPA 150
GIARVVEQQF EVAAQVVAAG LIPIIEPEVD INNVDKVQCE EILRDEIRKH 200
LNALPETSNV MLKLTLPTVE NLYEEFTKHP RVVRVVALSG GYSREKANDI 250
LSKNKGVIAS FSRALTEGLS AQQTDEEFNK TLAASIDGIY EASVK 295
Length:295
Mass (Da):32,896
Last modified:June 1, 2002 - v1
Checksum:i492DA50FBAC26495
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL94528.1.
RefSeqiNP_603229.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL94528; AAL94528; FN0322.
GeneIDi991677.
KEGGifnu:FN0322.
PATRICi21950419. VBIFusNuc122357_0902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL94528.1 .
RefSeqi NP_603229.1. NC_003454.1.

3D structure databases

ProteinModelPortali Q8RGH3.
SMRi Q8RGH3. Positions 1-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190304.FN0322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL94528 ; AAL94528 ; FN0322 .
GeneIDi 991677.
KEGGi fnu:FN0322.
PATRICi 21950419. VBIFusNuc122357_0902.

Phylogenomic databases

eggNOGi COG3588.
HOGENOMi HOG000073502.
KOi K01623.
OMAi YTGDYLA.
OrthoDBi EOG6M6JJT.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00729. FBP_aldolase_1.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiALF1_FUSNN
AccessioniPrimary (citable) accession number: Q8RGH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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