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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei132L-tryptophanUniRule annotation1
Binding sitei184ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi144 – 146ATPUniRule annotation3
Nucleotide bindingi191 – 195ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNUC190304:G1FZS-999-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:FN0405
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366321 – 325Tryptophan--tRNA ligaseAdd BLAST325

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190304.FN0405

Structurei

3D structure databases

ProteinModelPortaliQ8RGA3
SMRiQ8RGA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi191 – 195"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059939
InParanoidiQ8RGA3
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RGA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSLSGIQP SGILHIGNYF GAMKQFVDLQ DSYDGFYFIA DYHSLTSLTK
60 70 80 90 100
AETLKENTYN IVLDYLAVGL DPSKSTIFLQ SNVPEHTELT WLLSNITPVG
110 120 130 140 150
LLERGHSYKD KIAKGIPSNT GLLTYPVLMA ADILIYDSDV VPVGKDQKQH
160 170 180 190 200
LEMTRDIAMK FNQQYGVEFF KLPEPLILDD SAIVPGTDGQ KMSKSYNNTI
210 220 230 240 250
NMFATKKKLK EQVMSIVTDS TPLEEPKNPD NNIAKIYALF NNIDKQNELK
260 270 280 290 300
DKFLAGNFGY GHAKTELLNS ILEYFGTARE KREELEKNMD YVKDVLNEGS
310 320
KKARTIAIEK IKKAKEIVGL VGNIY
Length:325
Mass (Da):36,597
Last modified:June 1, 2002 - v1
Checksum:i1036D931A3FC1E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA Translation: AAL94608.1
RefSeqiNP_603309.1, NC_003454.1
WP_011016366.1, NC_003454.1

Genome annotation databases

EnsemblBacteriaiAAL94608; AAL94608; FN0405
GeneIDi991263
KEGGifnu:FN0405
PATRICifig|190304.8.peg.980

Similar proteinsi

Entry informationi

Entry nameiSYW_FUSNN
AccessioniPrimary (citable) accession number: Q8RGA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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