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Q8RGA3 (SYW_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:FN0405
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136632

Regions

Motif10 – 189"HIGH" region HAMAP-Rule MF_00140
Motif191 – 1955"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1941ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RGA3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 1036D931A3FC1E6E

FASTA32536,597
        10         20         30         40         50         60 
MKRSLSGIQP SGILHIGNYF GAMKQFVDLQ DSYDGFYFIA DYHSLTSLTK AETLKENTYN 

        70         80         90        100        110        120 
IVLDYLAVGL DPSKSTIFLQ SNVPEHTELT WLLSNITPVG LLERGHSYKD KIAKGIPSNT 

       130        140        150        160        170        180 
GLLTYPVLMA ADILIYDSDV VPVGKDQKQH LEMTRDIAMK FNQQYGVEFF KLPEPLILDD 

       190        200        210        220        230        240 
SAIVPGTDGQ KMSKSYNNTI NMFATKKKLK EQVMSIVTDS TPLEEPKNPD NNIAKIYALF 

       250        260        270        280        290        300 
NNIDKQNELK DKFLAGNFGY GHAKTELLNS ILEYFGTARE KREELEKNMD YVKDVLNEGS 

       310        320 
KKARTIAIEK IKKAKEIVGL VGNIY 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL94608.1.
RefSeqNP_603309.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RGA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0405.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94608; AAL94608; FN0405.
GeneID991263.
KEGGfnu:FN0405.
PATRIC21950581. VBIFusNuc122357_0980.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMALELYWIL.
OrthoDBEOG686NJQ.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_FUSNN
AccessionPrimary (citable) accession number: Q8RGA3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries