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Q8RG98 (K6PF_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase

Short name=Phosphofructokinase
EC=2.7.1.11
Alternative name(s):
Phosphohexokinase
Gene names
Name:pfkA
Ordered Locus Names:FN0410
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Sequence caution

The sequence AAL94613.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3223226-phosphofructokinase HAMAP-Rule MF_00339
PRO_0000111954

Regions

Nucleotide binding22 – 265ATP By similarity
Nucleotide binding156 – 1605ATP By similarity
Nucleotide binding173 – 18917ATP By similarity

Sites

Active site1291Proton acceptor By similarity
Metal binding1871Magnesium; via carbonyl oxygen By similarity
Binding site1641Substrate By similarity
Binding site2451Substrate By similarity
Binding site2511Substrate By similarity
Binding site2541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RG98 [UniParc].

Last modified May 16, 2003. Version 2.
Checksum: 323E7D70C19A8874

FASTA32234,931
        10         20         30         40         50         60 
MEKKLAILTS GGDAPGMNAA IRATAKIAEY YGFEVYGIRR GYLGMLNDEI FPMTGRFVSG 

        70         80         90        100        110        120 
IIDKGGTVLL TARSEEFKEA RFREIAANNL KKKGINYLVV IGGDGSYRGA NLLYKEHGIK 

       130        140        150        160        170        180 
VVGIPGTIDN DICGTDFTLG FDTCLNTILD AMSKIRDTAT SHERTILIQV MGRRAGDLAL 

       190        200        210        220        230        240 
HACIAGGGDG IMIPEMDNPI EMLALQLKER RKNGKLHDIV LVAEGVGNVL DIEEKLKGHI 

       250        260        270        280        290        300 
NSEIRSVVLG HIQRGGTPSG FDRVLASRMA AKAVEVLNKG EAGVMVGIEK NEMVTHPLEE 

       310        320 
ACSVDKRKSI EKDYELALLL SK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL94613.1. Different initiation.
RefSeqNP_603314.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RG98.
SMRQ8RG98. Positions 3-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0410.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94613; AAL94613; FN0410.
GeneID991774.
KEGGfnu:FN0410.
PATRIC21950591. VBIFusNuc122357_0985.

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248870.
KOK00850.
OMAKMVHHDI.
OrthoDBEOG644ZRM.
ProtClustDBPRK03202.

Enzyme and pathway databases

UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02482. PFKA_ATP. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF_FUSNN
AccessionPrimary (citable) accession number: Q8RG98
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 16, 2003
Last modified: April 16, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways