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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNUC190304:G1FZS-1098-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:FN0506
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
Proteomesi
  • UP000002521 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001515611 – 569Arginine--tRNA ligaseAdd BLAST569

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi190304.FN0506

Structurei

3D structure databases

ProteinModelPortaliQ8RG14
SMRiQ8RG14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 133"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247212
InParanoidiQ8RG14
KOiK01887
OMAiNKPLHLG

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.701 hit
3.40.50.6201 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RG14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITSRELTD IFQKHVENLF PNKELKPVEI TVATNENFGD YQCNFAMINS
60 70 80 90 100
KIIGDNPRKI AEEVKNNFPY GDVIEKLEVA GPGFINIFLS DKYISNSIKK
110 120 130 140 150
IGEDYDFSFL NRKGKVIIDF SSPNIAKRMH IGHLRSTIIG ESISRIYRFL
160 170 180 190 200
GYDVVADNHI GDWGTQFGKL IVGYRNWLDK KAYKKNAIEE LERVYVKFSD
210 220 230 240 250
EAEKDPSLED LARAELKKVQ DGEEENTKLW KEFITESLKE YNKLYKRLDV
260 270 280 290 300
HFDTYYGESF YNDMMADVVK ELVDKKIAVD DDGAKVVFFD EKDNLFPCIV
310 320 330 340 350
QKKDGAYLYS TSDIATVKFR KNTYDVNRMI YLTDARQQDH FKQFFKITDM
360 370 380 390 400
LGWNIEKYHI WFGIIRFADG ILSTRKGNVI KLEELLDEAH SRAYDVVNEK
410 420 430 440 450
NPNLSEGEKQ NIAEVVGVSS VKYADLSQNK QSDIIFEWDK MLSFEGNTAP
460 470 480 490 500
YLLYTYARIQ SILRKVAELN IGLNENIEIK TENKIEKSLA TYLLAFPISV
510 520 530 540 550
LKAGETFKPN LIADYLYELS KKLNSFYNNC PILNQDIETL KSRALLIKKT
560
GEVLKEGLEL LGIPILNKM
Length:569
Mass (Da):65,719
Last modified:June 1, 2002 - v1
Checksum:i410C64E85FFD7E2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA Translation: AAL94702.1
RefSeqiNP_603403.1, NC_003454.1
WP_011016438.1, NC_003454.1

Genome annotation databases

EnsemblBacteriaiAAL94702; AAL94702; FN0506
GeneIDi992846
KEGGifnu:FN0506
PATRICifig|190304.8.peg.1076

Similar proteinsi

Entry informationi

Entry nameiSYR_FUSNN
AccessioniPrimary (citable) accession number: Q8RG14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome