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Q8RG14 (SYR_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:FN0506
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151561

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8RG14 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 410C64E85FFD7E2F

FASTA56965,719
        10         20         30         40         50         60 
MKITSRELTD IFQKHVENLF PNKELKPVEI TVATNENFGD YQCNFAMINS KIIGDNPRKI 

        70         80         90        100        110        120 
AEEVKNNFPY GDVIEKLEVA GPGFINIFLS DKYISNSIKK IGEDYDFSFL NRKGKVIIDF 

       130        140        150        160        170        180 
SSPNIAKRMH IGHLRSTIIG ESISRIYRFL GYDVVADNHI GDWGTQFGKL IVGYRNWLDK 

       190        200        210        220        230        240 
KAYKKNAIEE LERVYVKFSD EAEKDPSLED LARAELKKVQ DGEEENTKLW KEFITESLKE 

       250        260        270        280        290        300 
YNKLYKRLDV HFDTYYGESF YNDMMADVVK ELVDKKIAVD DDGAKVVFFD EKDNLFPCIV 

       310        320        330        340        350        360 
QKKDGAYLYS TSDIATVKFR KNTYDVNRMI YLTDARQQDH FKQFFKITDM LGWNIEKYHI 

       370        380        390        400        410        420 
WFGIIRFADG ILSTRKGNVI KLEELLDEAH SRAYDVVNEK NPNLSEGEKQ NIAEVVGVSS 

       430        440        450        460        470        480 
VKYADLSQNK QSDIIFEWDK MLSFEGNTAP YLLYTYARIQ SILRKVAELN IGLNENIEIK 

       490        500        510        520        530        540 
TENKIEKSLA TYLLAFPISV LKAGETFKPN LIADYLYELS KKLNSFYNNC PILNQDIETL 

       550        560 
KSRALLIKKT GEVLKEGLEL LGIPILNKM 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL94702.1.
RefSeqNP_603403.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RG14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0506.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94702; AAL94702; FN0506.
GeneID992846.
KEGGfnu:FN0506.
PATRIC21950787. VBIFusNuc122357_1076.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_FUSNN
AccessionPrimary (citable) accession number: Q8RG14
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries