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Q8REV7 (PUR2_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:FN0981
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151451

Regions

Domain107 – 313207ATP-grasp
Nucleotide binding133 – 19462ATP By similarity

Sites

Metal binding2831Magnesium or manganese By similarity
Metal binding2851Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8REV7 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 297AB4260A3D9D5E

FASTA42647,319
        10         20         30         40         50         60 
MKVLIVGSGG REHAIAWKIS QNSKVDKIFA ASGNAYNKVI KNCENINLKT SDDILNFAIK 

        70         80         90        100        110        120 
EKVDLTIVGS EELLVDGIVD KFQENNLTIF GPNKEAAMLE GSKAFAKDFM QKYGVKTAKY 

       130        140        150        160        170        180 
QSFIDKEKAI KYLDKISYPV VIKASGLAAG KGVVIAQNRK EAEETLNDMM TNKVFAAAGD 

       190        200        210        220        230        240 
TVVIEEFLDG VEISVLSITD SEVIIPFISA KDHKKISEKE TGLNTGGMGV IAPNPYYTKT 

       250        260        270        280        290        300 
IEEKFIQNIL NPTLKGIKAE KMNFVGIIFF GLMVANGEVY LLEYNMRMGD PETQAVLPLM 

       310        320        330        340        350        360 
KSDFLNVINS ALNKDLKNIK IDWEDKSACC VVMAAGGYPV KYEKGNFISG LEKFDSNKSD 

       370        380        390        400        410        420 
NKIFFAGVKE ENDKFYTNGG RVLNVVSIKD SLEKAIEEAY KNVKEISFKD NYYRKDIGTL 


YVPVKY 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL95177.1.
RefSeqNP_603878.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8REV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0981.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL95177; AAL95177; FN0981.
GeneID991454.
KEGGfnu:FN0981.
PATRIC21951727. VBIFusNuc122357_1546.

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMADPEAMNV.
OrthoDBEOG69SKD1.
ProtClustDBPRK00885.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_FUSNN
AccessionPrimary (citable) accession number: Q8REV7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways