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Q8REV6 (PUR9_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:FN0982
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192094

Sequences

Sequence LengthMass (Da)Tools
Q8REV6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: ADCA67143AE64433

FASTA50456,927
        10         20         30         40         50         60 
MRKRALISVY DKTGILDFAK FLVSKGIEII STGGTYKYLK ENNIEVIEVS KITNFEEMLD 

        70         80         90        100        110        120 
GRVKTLHPNI HGGILALRDN EEHMRTLKER NIDTIDYVIV NLYPFFEKVK EDLSFEEKIE 

       130        140        150        160        170        180 
FIDIGGPTML RSAAKSFKNV VVISDVKDYE SIKEEINKSD DVSYEARKKL AGKVFNLTSA 

       190        200        210        220        230        240 
YDAAISQFLL DEDFSEYLNI SYKKFMEMRY GENSHQKAAY YTDNMTDGAM KDFKQLNGKE 

       250        260        270        280        290        300 
LSYNNIRDMD LAWKVVSEFD EICCCAVKHS TPCGVALGDN VEGAYKKAYE TDPVSIFGGI 

       310        320        330        340        350        360 
VAFNREVDEA TAKLLNEIFL EIIIAPSFSK AALEILTKKK NIRLIECKNK PSDKKELIKV 

       370        380        390        400        410        420 
DGGILIQDTN NKLYEDLEVV TKAKPTSQEE KDLIFALKVV KFVKSNAIVV AKNLQTLGIG 

       430        440        450        460        470        480 
GGEVSRIWAA EKALERAKER FNATDVVLSS DAFFPFKDVI ELAAKNGVKA IIQPSGSVND 

       490        500 
KDSIEECDRN NISMIFSKLR HFKH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL95178.1.
RefSeqNP_603879.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8REV6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0982.

Proteomic databases

PRIDEQ8REV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL95178; AAL95178; FN0982.
GeneID991332.
KEGGfnu:FN0982.
PATRIC21951729. VBIFusNuc122357_1547.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_FUSNN
AccessionPrimary (citable) accession number: Q8REV6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways