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Q8REV3

- PUR5_FUSNN

UniProt

Q8REV3 - PUR5_FUSNN

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, FN0986
Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:FN0986
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000148213Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190304.FN0986.

Structurei

3D structure databases

ProteinModelPortaliQ8REV3.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8REV3-1 [UniParc]FASTAAdd to Basket

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MINSYKDSGV DKEEGYKAVE LMKKNVLKTH NKSVLTNLGS FGAMYELGQY    50
KNPVLISGTD GVGTKLEIAM KQKKYDTVGI DCVAMCVNDV LCHGAKPLFF 100
LDYLACGKLD AEVAAQLVSG VTEGCLQSYA ALVGGETAEM PGFYKEGDYD 150
IAGFCVGIVE KEDLIDGSKV KEGNKIIAVA SSGFHSNGYS LVRKVFTDYN 200
EKIFLKEYGE NVTMGDVLLT PTKIYVKPIL KVLEKFNVNG MAHITGGGLF 250
ENLPRCMGKN LSPVVFKDKV RVPEIFKLIA ERSKIKEEEL FGTFNMGVGF 300
TLVVEEKDVE TIIELLTSLG ETAYEIGHIE KGDHSLCLK 339
Length:339
Mass (Da):37,126
Last modified:June 1, 2002 - v1
Checksum:iFF6C6C7B048C9572
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL95182.1.
RefSeqiNP_603883.1. NC_003454.1.
WP_011016807.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL95182; AAL95182; FN0986.
GeneIDi991451.
KEGGifnu:FN0986.
PATRICi21951737. VBIFusNuc122357_1551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009951 Genomic DNA. Translation: AAL95182.1 .
RefSeqi NP_603883.1. NC_003454.1.
WP_011016807.1. NC_003454.1.

3D structure databases

ProteinModelPortali Q8REV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190304.FN0986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL95182 ; AAL95182 ; FN0986 .
GeneIDi 991451.
KEGGi fnu:FN0986.
PATRICi 21951737. VBIFusNuc122357_1551.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiPUR5_FUSNN
AccessioniPrimary (citable) accession number: Q8REV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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