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Q8RDQ4 (DDL_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:FN1454
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177824

Regions

Domain98 – 283186ATP-grasp
Nucleotide binding124 – 16946ATP By similarity

Sites

Metal binding2381Magnesium or manganese 1 By similarity
Metal binding2501Magnesium or manganese 1 By similarity
Metal binding2501Magnesium or manganese 2 By similarity
Metal binding2521Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RDQ4 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 213241D408D247DE

FASTA28731,483
        10         20         30         40         50         60 
MRIAVFMGGT SSEKEISLKS GEAVLESLQK QGYDAYGVIL DERNQVSAFV DNDYDLAYLV 

        70         80         90        100        110        120 
LHGGNGENGK IQAVLDILGK KYTGSGVLAS AITMDKDKTK QIAQSVGIKT PKSYRPVEEI 

       130        140        150        160        170        180 
ERFPVIIKPV DEGSSKGLFL CNNKEEAEEA VKKLAKPIIE DYIIGEELTV GVLNGEALGV 

       190        200        210        220        230        240 
LKIIPQADVL YDYDSKYAKG GSVHEFPAKI ENKSYKEAMK IAEKIHSEFG MKGISRSDFI 

       250        260        270        280 
LSEGELYFLE VNSSPGMTKT SLIPDLATLK GYSFDDVVRI TVETFLE 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL95647.1.
RefSeqNP_604348.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8RDQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN1454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL95647; AAL95647; FN1454.
GeneID992375.
KEGGfnu:FN1454.
PATRIC21952669. VBIFusNuc122357_2014.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_FUSNN
AccessionPrimary (citable) accession number: Q8RDQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways