Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8RDK6

- Q8RDK6_THETN

UniProt

Q8RDK6 - Q8RDK6_THETN

Protein

DNA gyrase subunit A

Gene

GyrA

Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
    2. DNA topological change Source: InterPro

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Gene namesi
    Name:GyrAImported
    Synonyms:gyrAUniRule annotation
    Ordered Locus Names:TTE0011Imported
    OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)Imported
    Taxonomic identifieri273068 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
    ProteomesiUP000000555: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

    Protein-protein interaction databases

    STRINGi273068.TTE0011.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RDK6.
    SMRiQ8RDK6. Positions 30-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076279.
    KOiK02469.
    OMAiTTFGFNM.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_01897. GyrA.
    InterProiIPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01063. gyrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8RDK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEEMDKVIP VDIEDEMRNS YIDYAMSVIV GRALPDVRDG LKPVHRRILY    50
    AMNEMGLTPD KPYKKSVAVV GEVLGKYHPH GDAAVYDTLV RLAQDFSMRE 100
    VLIDGHGNFG SIDGDPPAAM RYTEARLSRI ALEMLTDINK ETVDFVPNFD 150
    ETLKEPVVLP SRFPNLLVNG SQGIAVGMAT NIPPHNLAEV IDGIVAYIDN 200
    PYITVDELMK YIKGPDFPTG GIILGRDGIK ETYETGRGKI IVRAKAEIEE 250
    HKGKTRIVIT EIPYMVLKAK LIEKIAELVH NKQIEGIADL RDESDRNGMK 300
    IVIELKRDVN PKVILNKLYM HTQMQQTFGA IMLALVDGEP KILNLKQIIE 350
    KYVDHQADVV TRRTKFDLKK AEERAHILEG LKIALDYIDE VINIIRSSKT 400
    EAIAKENLMK RFGLSDKQAQ AIVDMRLGRL TGLERQKVED ELKELIEKIK 450
    ELKEILADER KVLEIIKKEL LEIKNKYASP RKTVIVAKEE ELDFEDLVQL 500
    EDVVVTMTHY GYIKRMPLDT YKSQKRGGKG ILGISTREDD FVEDIFITTT 550
    HDRLLFFTNK GKVYSLRTID IPESGRQAKG TAIVNLIQIS QGEKVTAVIP 600
    LKKSDDIKYV LMCTKKGIIK KTSIEEFKSI KRNGIIAITL DENDELINVK 650
    LTNGEREVII GTAKGYAIRF NEKDVRPMGR VARGVMAISL REDDEVVEMD 700
    LVHPDGEVLT VTEKGFGKRT DLEEYRIQGR AGKGIIAMKL SKKTGKLVSI 750
    RCVQPEDEFM IISANGILIR MKVKDISKMH RDTQGVTLMK LEDGDRVVST 800
    ARIESEE 807
    Length:807
    Mass (Da):91,163
    Last modified:June 1, 2002 - v1
    Checksum:i6650EAA86AD34889
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM23328.1.
    RefSeqiNP_621724.1. NC_003869.1.

    Genome annotation databases

    EnsemblBacteriaiAAM23328; AAM23328; TTE0011.
    GeneIDi995451.
    KEGGitte:TTE0011.
    PATRICi23894645. VBITheTen82880_0011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM23328.1 .
    RefSeqi NP_621724.1. NC_003869.1.

    3D structure databases

    ProteinModelPortali Q8RDK6.
    SMRi Q8RDK6. Positions 30-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273068.TTE0011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM23328 ; AAM23328 ; TTE0011 .
    GeneIDi 995451.
    KEGGi tte:TTE0011.
    PATRICi 23894645. VBITheTen82880_0011.

    Phylogenomic databases

    HOGENOMi HOG000076279.
    KOi K02469.
    OMAi TTFGFNM.
    OrthoDBi EOG661H5V.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_01897. GyrA.
    InterProi IPR024946. Arg_repress_C-like.
    IPR005743. GyrA.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 6 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01063. gyrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4Imported.

    Entry informationi

    Entry nameiQ8RDK6_THETN
    AccessioniPrimary (citable) accession number: Q8RDK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3