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Protein

DNA gyrase subunit A

Gene

GyrA

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:GyrAImported
Synonyms:gyrAUniRule annotation
Ordered Locus Names:TTE0011Imported
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)Imported
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE0011.

Structurei

3D structure databases

ProteinModelPortaliQ8RDK6.
SMRiQ8RDK6. Positions 30-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076279.
KOiK02469.
OMAiKVYWLKV.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RDK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEEMDKVIP VDIEDEMRNS YIDYAMSVIV GRALPDVRDG LKPVHRRILY
60 70 80 90 100
AMNEMGLTPD KPYKKSVAVV GEVLGKYHPH GDAAVYDTLV RLAQDFSMRE
110 120 130 140 150
VLIDGHGNFG SIDGDPPAAM RYTEARLSRI ALEMLTDINK ETVDFVPNFD
160 170 180 190 200
ETLKEPVVLP SRFPNLLVNG SQGIAVGMAT NIPPHNLAEV IDGIVAYIDN
210 220 230 240 250
PYITVDELMK YIKGPDFPTG GIILGRDGIK ETYETGRGKI IVRAKAEIEE
260 270 280 290 300
HKGKTRIVIT EIPYMVLKAK LIEKIAELVH NKQIEGIADL RDESDRNGMK
310 320 330 340 350
IVIELKRDVN PKVILNKLYM HTQMQQTFGA IMLALVDGEP KILNLKQIIE
360 370 380 390 400
KYVDHQADVV TRRTKFDLKK AEERAHILEG LKIALDYIDE VINIIRSSKT
410 420 430 440 450
EAIAKENLMK RFGLSDKQAQ AIVDMRLGRL TGLERQKVED ELKELIEKIK
460 470 480 490 500
ELKEILADER KVLEIIKKEL LEIKNKYASP RKTVIVAKEE ELDFEDLVQL
510 520 530 540 550
EDVVVTMTHY GYIKRMPLDT YKSQKRGGKG ILGISTREDD FVEDIFITTT
560 570 580 590 600
HDRLLFFTNK GKVYSLRTID IPESGRQAKG TAIVNLIQIS QGEKVTAVIP
610 620 630 640 650
LKKSDDIKYV LMCTKKGIIK KTSIEEFKSI KRNGIIAITL DENDELINVK
660 670 680 690 700
LTNGEREVII GTAKGYAIRF NEKDVRPMGR VARGVMAISL REDDEVVEMD
710 720 730 740 750
LVHPDGEVLT VTEKGFGKRT DLEEYRIQGR AGKGIIAMKL SKKTGKLVSI
760 770 780 790 800
RCVQPEDEFM IISANGILIR MKVKDISKMH RDTQGVTLMK LEDGDRVVST

ARIESEE
Length:807
Mass (Da):91,163
Last modified:June 1, 2002 - v1
Checksum:i6650EAA86AD34889
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23328.1.
RefSeqiNP_621724.1. NC_003869.1.
WP_011024547.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23328; AAM23328; TTE0011.
KEGGitte:TTE0011.
PATRICi23894645. VBITheTen82880_0011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23328.1.
RefSeqiNP_621724.1. NC_003869.1.
WP_011024547.1. NC_003869.1.

3D structure databases

ProteinModelPortaliQ8RDK6.
SMRiQ8RDK6. Positions 30-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273068.TTE0011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM23328; AAM23328; TTE0011.
KEGGitte:TTE0011.
PATRICi23894645. VBITheTen82880_0011.

Phylogenomic databases

HOGENOMiHOG000076279.
KOiK02469.
OMAiKVYWLKV.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4Imported.

Entry informationi

Entry nameiQ8RDK6_CALS4
AccessioniPrimary (citable) accession number: Q8RDK6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 27, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.