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Q8RDK6 (Q8RDK6_THETN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length807 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP-Rule MF_01897

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q8RDK6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 6650EAA86AD34889

FASTA80791,163
        10         20         30         40         50         60 
MNEEMDKVIP VDIEDEMRNS YIDYAMSVIV GRALPDVRDG LKPVHRRILY AMNEMGLTPD 

        70         80         90        100        110        120 
KPYKKSVAVV GEVLGKYHPH GDAAVYDTLV RLAQDFSMRE VLIDGHGNFG SIDGDPPAAM 

       130        140        150        160        170        180 
RYTEARLSRI ALEMLTDINK ETVDFVPNFD ETLKEPVVLP SRFPNLLVNG SQGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLAEV IDGIVAYIDN PYITVDELMK YIKGPDFPTG GIILGRDGIK ETYETGRGKI 

       250        260        270        280        290        300 
IVRAKAEIEE HKGKTRIVIT EIPYMVLKAK LIEKIAELVH NKQIEGIADL RDESDRNGMK 

       310        320        330        340        350        360 
IVIELKRDVN PKVILNKLYM HTQMQQTFGA IMLALVDGEP KILNLKQIIE KYVDHQADVV 

       370        380        390        400        410        420 
TRRTKFDLKK AEERAHILEG LKIALDYIDE VINIIRSSKT EAIAKENLMK RFGLSDKQAQ 

       430        440        450        460        470        480 
AIVDMRLGRL TGLERQKVED ELKELIEKIK ELKEILADER KVLEIIKKEL LEIKNKYASP 

       490        500        510        520        530        540 
RKTVIVAKEE ELDFEDLVQL EDVVVTMTHY GYIKRMPLDT YKSQKRGGKG ILGISTREDD 

       550        560        570        580        590        600 
FVEDIFITTT HDRLLFFTNK GKVYSLRTID IPESGRQAKG TAIVNLIQIS QGEKVTAVIP 

       610        620        630        640        650        660 
LKKSDDIKYV LMCTKKGIIK KTSIEEFKSI KRNGIIAITL DENDELINVK LTNGEREVII 

       670        680        690        700        710        720 
GTAKGYAIRF NEKDVRPMGR VARGVMAISL REDDEVVEMD LVHPDGEVLT VTEKGFGKRT 

       730        740        750        760        770        780 
DLEEYRIQGR AGKGIIAMKL SKKTGKLVSI RCVQPEDEFM IISANGILIR MKVKDISKMH 

       790        800 
RDTQGVTLMK LEDGDRVVST ARIESEE 

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References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008691 Genomic DNA. Translation: AAM23328.1.
RefSeqNP_621724.1. NC_003869.1.

3D structure databases

ProteinModelPortalQ8RDK6.
SMRQ8RDK6. Positions 30-485.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273068.TTE0011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM23328; AAM23328; TTE0011.
GeneID995451.
KEGGtte:TTE0011.
PATRIC23894645. VBITheTen82880_0011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000076279.
KOK02469.
OMAETVDWVP.
OrthoDBEOG661H5V.
ProtClustDBPRK05560.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ8RDK6_THETN
AccessionPrimary (citable) accession number: Q8RDK6
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)