Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8RDK6

- Q8RDK6_CALS4

UniProt

Q8RDK6 - Q8RDK6_CALS4

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA gyrase subunit A

Gene

GyrA

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-dependent DNA replication Source: UniProtKB-HAMAP
  2. DNA topological change Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:GyrAImported
Synonyms:gyrAUniRule annotation
Ordered Locus Names:TTE0011Imported
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)Imported
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE0011.

Structurei

3D structure databases

ProteinModelPortaliQ8RDK6.
SMRiQ8RDK6. Positions 30-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the topoisomerase GyrA/ParC subunit family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076279.
KOiK02469.
OMAiTTFGFNM.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RDK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEEMDKVIP VDIEDEMRNS YIDYAMSVIV GRALPDVRDG LKPVHRRILY
60 70 80 90 100
AMNEMGLTPD KPYKKSVAVV GEVLGKYHPH GDAAVYDTLV RLAQDFSMRE
110 120 130 140 150
VLIDGHGNFG SIDGDPPAAM RYTEARLSRI ALEMLTDINK ETVDFVPNFD
160 170 180 190 200
ETLKEPVVLP SRFPNLLVNG SQGIAVGMAT NIPPHNLAEV IDGIVAYIDN
210 220 230 240 250
PYITVDELMK YIKGPDFPTG GIILGRDGIK ETYETGRGKI IVRAKAEIEE
260 270 280 290 300
HKGKTRIVIT EIPYMVLKAK LIEKIAELVH NKQIEGIADL RDESDRNGMK
310 320 330 340 350
IVIELKRDVN PKVILNKLYM HTQMQQTFGA IMLALVDGEP KILNLKQIIE
360 370 380 390 400
KYVDHQADVV TRRTKFDLKK AEERAHILEG LKIALDYIDE VINIIRSSKT
410 420 430 440 450
EAIAKENLMK RFGLSDKQAQ AIVDMRLGRL TGLERQKVED ELKELIEKIK
460 470 480 490 500
ELKEILADER KVLEIIKKEL LEIKNKYASP RKTVIVAKEE ELDFEDLVQL
510 520 530 540 550
EDVVVTMTHY GYIKRMPLDT YKSQKRGGKG ILGISTREDD FVEDIFITTT
560 570 580 590 600
HDRLLFFTNK GKVYSLRTID IPESGRQAKG TAIVNLIQIS QGEKVTAVIP
610 620 630 640 650
LKKSDDIKYV LMCTKKGIIK KTSIEEFKSI KRNGIIAITL DENDELINVK
660 670 680 690 700
LTNGEREVII GTAKGYAIRF NEKDVRPMGR VARGVMAISL REDDEVVEMD
710 720 730 740 750
LVHPDGEVLT VTEKGFGKRT DLEEYRIQGR AGKGIIAMKL SKKTGKLVSI
760 770 780 790 800
RCVQPEDEFM IISANGILIR MKVKDISKMH RDTQGVTLMK LEDGDRVVST

ARIESEE
Length:807
Mass (Da):91,163
Last modified:June 1, 2002 - v1
Checksum:i6650EAA86AD34889
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23328.1.
RefSeqiNP_621724.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23328; AAM23328; TTE0011.
GeneIDi995451.
KEGGitte:TTE0011.
PATRICi23894645. VBITheTen82880_0011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23328.1 .
RefSeqi NP_621724.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RDK6.
SMRi Q8RDK6. Positions 30-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23328 ; AAM23328 ; TTE0011 .
GeneIDi 995451.
KEGGi tte:TTE0011.
PATRICi 23894645. VBITheTen82880_0011.

Phylogenomic databases

HOGENOMi HOG000076279.
KOi K02469.
OMAi TTFGFNM.
OrthoDBi EOG661H5V.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_01897. GyrA.
InterProi IPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01063. gyrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4Imported.

Entry informationi

Entry nameiQ8RDK6_CALS4
AccessioniPrimary (citable) accession number: Q8RDK6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3