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Q8RDK6

- Q8RDK6_THETN

UniProt

Q8RDK6 - Q8RDK6_THETN

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Protein
DNA gyrase subunit A
Gene
GyrA, gyrA, TTE0011
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221O-(5'-phospho-DNA)-tyrosine intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA topological change Source: InterPro
  2. DNA-dependent DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, DNA-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Gene namesi
Name:GyrAImported
Synonyms:gyrAUniRule annotation
Ordered Locus Names:TTE0011Imported
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)Imported
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE0011.

Structurei

3D structure databases

ProteinModelPortaliQ8RDK6.
SMRiQ8RDK6. Positions 30-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076279.
KOiK02469.
OMAiTTFGFNM.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_01897. GyrA.
InterProiIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01063. gyrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RDK6-1 [UniParc]FASTAAdd to Basket

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MNEEMDKVIP VDIEDEMRNS YIDYAMSVIV GRALPDVRDG LKPVHRRILY    50
AMNEMGLTPD KPYKKSVAVV GEVLGKYHPH GDAAVYDTLV RLAQDFSMRE 100
VLIDGHGNFG SIDGDPPAAM RYTEARLSRI ALEMLTDINK ETVDFVPNFD 150
ETLKEPVVLP SRFPNLLVNG SQGIAVGMAT NIPPHNLAEV IDGIVAYIDN 200
PYITVDELMK YIKGPDFPTG GIILGRDGIK ETYETGRGKI IVRAKAEIEE 250
HKGKTRIVIT EIPYMVLKAK LIEKIAELVH NKQIEGIADL RDESDRNGMK 300
IVIELKRDVN PKVILNKLYM HTQMQQTFGA IMLALVDGEP KILNLKQIIE 350
KYVDHQADVV TRRTKFDLKK AEERAHILEG LKIALDYIDE VINIIRSSKT 400
EAIAKENLMK RFGLSDKQAQ AIVDMRLGRL TGLERQKVED ELKELIEKIK 450
ELKEILADER KVLEIIKKEL LEIKNKYASP RKTVIVAKEE ELDFEDLVQL 500
EDVVVTMTHY GYIKRMPLDT YKSQKRGGKG ILGISTREDD FVEDIFITTT 550
HDRLLFFTNK GKVYSLRTID IPESGRQAKG TAIVNLIQIS QGEKVTAVIP 600
LKKSDDIKYV LMCTKKGIIK KTSIEEFKSI KRNGIIAITL DENDELINVK 650
LTNGEREVII GTAKGYAIRF NEKDVRPMGR VARGVMAISL REDDEVVEMD 700
LVHPDGEVLT VTEKGFGKRT DLEEYRIQGR AGKGIIAMKL SKKTGKLVSI 750
RCVQPEDEFM IISANGILIR MKVKDISKMH RDTQGVTLMK LEDGDRVVST 800
ARIESEE 807
Length:807
Mass (Da):91,163
Last modified:June 1, 2002 - v1
Checksum:i6650EAA86AD34889
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23328.1.
RefSeqiNP_621724.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23328; AAM23328; TTE0011.
GeneIDi995451.
KEGGitte:TTE0011.
PATRICi23894645. VBITheTen82880_0011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23328.1 .
RefSeqi NP_621724.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RDK6.
SMRi Q8RDK6. Positions 30-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23328 ; AAM23328 ; TTE0011 .
GeneIDi 995451.
KEGGi tte:TTE0011.
PATRICi 23894645. VBITheTen82880_0011.

Phylogenomic databases

HOGENOMi HOG000076279.
KOi K02469.
OMAi TTFGFNM.
OrthoDBi EOG661H5V.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_01897. GyrA.
InterProi IPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01063. gyrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiQ8RDK6_THETN
AccessioniPrimary (citable) accession number: Q8RDK6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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