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Q8RDA1 (KITH_THETN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175041

Regions

Nucleotide binding16 – 238ATP By similarity
Nucleotide binding89 – 924ATP By similarity

Sites

Active site901Proton acceptor Potential
Metal binding1461Zinc By similarity
Metal binding1491Zinc By similarity
Metal binding1841Zinc By similarity
Metal binding1871Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RDA1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: BCC4544FD2365F24

FASTA19321,459
        10         20         30         40         50         60 
MIYGSLDHGF IEVIVGPMFS GKSEELIRRI RRAQIAKQKV QVFKPAIDDR YSIDKVVSHN 

        70         80         90        100        110        120 
GSSINAISVT KASEILDLLE EDTQVVAIDE IQFFDHSLVD VVREIADMGK RVICAGLDMD 

       130        140        150        160        170        180 
FRGEPFGVTP DIMAIAESVD KLTAICVKCG NPATRTQRLI NGKPAKYDDP IILVGAHETY 

       190 
EARCRKCHEV PRT 

« Hide

References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008691 Genomic DNA. Translation: AAM23444.1.
RefSeqNP_621840.1. NC_003869.1.

3D structure databases

ProteinModelPortalQ8RDA1.
SMRQ8RDA1. Positions 3-192.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273068.TTE0140.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM23444; AAM23444; TTE0140.
GeneID996478.
KEGGtte:TTE0140.
PATRIC23894917. VBITheTen82880_0134.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMAQAICLSC.
OrthoDBEOG69D3J2.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_THETN
AccessionPrimary (citable) accession number: Q8RDA1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families