Reviewed, UniProtKB/Swiss-Prot Q8RD88 (MURA1_THETN)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murA1
Ordered Locus Names:	TTE0158

Organism

Thermoanaerobacter tengcongensis [Complete proteome] [HAMAP]

Taxonomic identifier

119072 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP MF_00111
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable HAMAP MF_00111.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000178944
Sites
	Active site	116	1	Proton donor By similarity
	Binding site	116	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8RD88-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B5DE3BB98B8D4FC9	FASTA	415	44,670
	10 20 30 40 50 60 MKTKFVVEKS PPLKGTVKIS GAKNSVLPII AASLLSSDEV ILEDIPSLED VNVMIELIKN 70 80 90 100 110 120 FGALCELDNG KLKIKVDIKD VEAPYELVKK MRASFLVMGP ILAKLGHAKI SMPGGCAIGA 130 140 150 160 170 180 RPIDLHLKGF QSLGADITIG HGYVEARAKK LTGKKIYLDF PSVGATENIM MAAVFADGVT 190 200 210 220 230 240 VIENAAEEPE IVDLANFLNK MGANIKGAGT DTIRIEGVKE LKGAEHTVIP DRIEAGTFMV 250 260 270 280 290 300 AAAMTGGNVL IENVIVDHVR SVIAKLTECG VKITEEKGGL RVKGVKNYKA VDIKTLPYPG 310 320 330 340 350 360 FPTDMQAQMM AMMTVAKGTS VIIETVFENR FMHVSELKRM GANIKIEGRS AMITGVDHLT 370 380 390 400 410 GAEVKATDLR AGAALVLAGL IAEGRTEIND IYHVDRGYVK MEEKLRALGA KIYRK

References

[1]

"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008691 Genomic DNA. Translation: AAM23459.1.
RefSeq	NP_621855.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	996500.
GenomeReviews	Gene locus TTE0158 in contig AE008691_GR.
KEGG	tte:TTE0158.
NMPDR	fig|273068.3.peg.575.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG482701.
OMA	VSRVYHL.
Enzyme and pathway databases
BioCyc	TTEN273068:TTE0158-MONOMER.
BRENDA	2.5.1.7. 276887.
Family and domain databases
HAMAP	MF_00111. MurA. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_THETN

Accession

Primary (citable) accession number: Q8RD88

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	June 1, 2002
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)