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Q8RD52 (Q8RD52_THETN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding8 – 136NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding31 – 333NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding73 – 753NADP By similarity PIRSR PIRSR000109-3
Region127 – 1293Substrate binding By similarity PIRSR PIRSR000109-2
Region184 – 1852Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1811Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1881Proton donor By similarity PIRSR PIRSR000109-1
Binding site1011NADP By similarity PIRSR PIRSR000109-3
Binding site1011Substrate By similarity PIRSR PIRSR000109-2
Binding site1891Substrate By similarity PIRSR PIRSR000109-2
Binding site2591Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2861Substrate By similarity PIRSR PIRSR000109-2
Binding site4441Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4501Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q8RD52 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 6F165EEE167DC8A3

FASTA46753,392
        10         20         30         40         50         60 
MNDVGLIGLA VMGQNFALNM ARKGYRVSVY NRTPERTKKF VEEKVRDESI FPFYTIEEFV 

        70         80         90        100        110        120 
KSLKKPRKII LMIKAGKAVD DMIAEILPYL ELGDLIVDSG NSHFADTARR LEYLSQKNIL 

       130        140        150        160        170        180 
FLGMGISGGE YGALHGPSLM PGGTKEAYDL IKDILLKAAA KTEDGPCCTY VGKGSAGHFV 

       190        200        210        220        230        240 
KMVHNGIEYA IMQLIAEVYD FMKKVLNMTN EQIGDVFEKW NKGELNSYLM EISYKIMRYK 

       250        260        270        280        290        300 
DKETGGFLID YILDKAEQKG TGKWTAQTSL DLGVPTPTLN LAVEARIISH YKEERKILSK 

       310        320        330        340        350        360 
LYSKEKNIIS VNKEEMIEHL KKALLFGVFM SFSQGLWLID EASKQYNYGI DLSEILRIWK 

       370        380        390        400        410        420 
GGCIIRAEIL DFLRDIIREN EEDANLLHSD KAIDFIKDKL NSIYQVTEIG KNYRIPLMTM 

       430        440        450        460 
NSALDYYFAL TEENLPANII QAQRDFFGAH TYERIDREGI FHTEWER

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References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE008691 Genomic DNA. Translation: AAM23496.1.
RefSeqNP_621892.1. NC_003869.1.

3D structure databases

HSSPHSSP built from PDB template 2PGD based on UniProtKB P00349.
ProteinModelPortalQ8RD52.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID995882.
GenomeReviewsGene locus TTE0195 in contig AE008691_GR.
KEGGtte:TTE0195.
NMPDRfig|273068.3.peg.806.
PATRIC23895033. VBITheTen82880_0192.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMAPECASAH.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycTTEN273068:TTE0195-MONOMER.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8RD52_THETN
AccessionPrimary (citable) accession number: Q8RD52
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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