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Q8RCX1 (HPPA_THETN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
K(+)-insensitive pyrophosphate-energized proton pump
EC=3.6.1.1
Alternative name(s):
Membrane-bound proton-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Short name=H(+)-PPase
Gene names
Name:hppA
Ordered Locus Names:TTE0284
OrganismThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]
Taxonomic identifier273068 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Caldanaerobacter

Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force By similarity. HAMAP MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01129

Cofactor

Magnesium By similarity. HAMAP MF_01129

Subunit structure

Homodimer By similarity. HAMAP MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification]

Ontologies

Keywords
   Biological processHydrogen ion transport
Ion transport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproton transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhydrogen-translocating pyrophosphatase activity

Inferred from electronic annotation. Source: InterPro

inorganic diphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711K(+)-insensitive pyrophosphate-energized proton pump HAMAP MF_01129
PRO_0000217033

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane403 – 42321Helical; Potential
Transmembrane431 – 45121Helical; Potential
Transmembrane495 – 51521Helical; Potential
Transmembrane535 – 55521Helical; Potential
Transmembrane602 – 62221Helical; Potential
Transmembrane624 – 64421Helical; Potential
Transmembrane690 – 71021Helical; Potential

Sites

Site4891Determinant of potassium independence By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RCX1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 90535FD7C6DC004B

FASTA71174,381
        10         20         30         40         50         60 
MGAYLTLIYG VIVIAALVII GLIKFIFAQD KGNEKMQQIS DAIKEGAMAF LNRQYKTIAS 

        70         80         90        100        110        120 
LALIVAVIIV VANYYGHLSE GSSQALSFAL HVGFAFITGA FCSALSGYIG MYMAVNSNIR 

       130        140        150        160        170        180 
AAAGARSGLN RALQIALKGG AVTGLAVTAL SLFGVATLFL AYGGLSGQDE LIKEAPSLIV 

       190        200        210        220        230        240 
GFGFGASFVA LFAQLGGGIY TKAADVGADL VGKVEAGIPE DDPRNPAVIA DLVGDNVGDC 

       250        260        270        280        290        300 
AGRGADLFES TAAENIGAMI LGVGLYPIFG WKGILFPLVA RAIGIIASII GIFFVNTKDE 

       310        320        330        340        350        360 
SKDPMIALNK GYFVTTVVNL IALFFAVKVM LSGHLPDGRP VNYLLLYGAV VTGVILSYIF 

       370        380        390        400        410        420 
VFLTDYYTSV NKRPVQEIAK ASTTGAATNI ITGTSVGMES TALPVIFISA AIYIAYKLGE 

       430        440        450        460        470        480 
MAIPHIGTAG LYGTAIATMG MLSTTAYILA MDTFGPITDN AGGITEMSGA PEEIRRVTDR 

       490        500        510        520        530        540 
LDACGNTTKA LTKGYAIGSA ALATFLLFSA YLDEVKKILG KPIDSWFPVD IGKPEVFIGA 

       550        560        570        580        590        600 
FIGAMIVYLF SSTAIRAVGK AAQYVILEVR RQFREIPGIM EGTAKPDYAR AVDIVTKGAL 

       610        620        630        640        650        660 
KEMVIPGLIV VVTPILVGVI LGKEAAAAFL MIGTISGVIL ALYLNNGGGA WDNAKKFIEL 

       670        680        690        700        710 
GNYGGKGSDA HKASVVGDTV GDPFKDTAGP SLHVLIKLIS TITLVFVALF R

« Hide

References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE008691 Genomic DNA. Translation: AAM23580.1.
RefSeqNP_621976.1. NC_003869.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID997931.
GenomeReviewsGene locus TTE0284 in contig AE008691_GR.
KEGGtte:TTE0284.
NMPDRfig|273068.3.peg.1212.
PATRIC23895205. VBITheTen82880_0278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG593668.
OMAAINRGFF.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycTTEN273068:TTE0284-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase-energized_pump.
[Tree]
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
KOK01507.
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPA_THETN
AccessionPrimary (citable) accession number: Q8RCX1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2002
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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