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Q8RCW2

- GCSPB_THETN

UniProt

Q8RCW2 - GCSPB_THETN

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, gcvP, TTE0293
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Synonyms:gcvP
Ordered Locus Names:TTE0293
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi273068.TTE0293.

Structurei

3D structure databases

ProteinModelPortaliQ8RCW2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RCW2-1 [UniParc]FASTAAdd to Basket

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MLKEYNSLIF ELSKEGKKAY TLPPLDVEEK PLEDMLPKEM LREKEVDLPE    50
VSEVDVIRHY TLLSQKNYGV DIGFYPLGSC TMKYNPKINE DMASLPGFTE 100
LHPYQPEETV QGALKLMYEL EKALCEITGM DRFSLHPAAG AHGELTGLMI 150
IKAYHEHRND KKRKKIIVPD SAHGTNPASA AVAGFDVIEI KSNKEGAIDL 200
EALKAVLNDE VAGLMLTNPS TLGLFEENIV EIARLVHEAG GLLYYDGANL 250
NAIMGISRPG DMGFDVVHLN LHKTFSTPHG GGGPGSGPVG VKKELADFLP 300
VPTVEEKDGR YFLDYDRPLS IGKVRSFYGN FNVMIKAYSY ILTMGAEGLK 350
RASELAVLNA NYLKEKLKGY YKVAVDKTCM HEFVLAGLAE KSGDVRTLDV 400
AKRLIDYGFH PPTIYFPLIV EEALMIEPTE TETKETLDAF AETLIKIAKE 450
AKENPELLKE APHNTPVRRL DEVLAARNPV IRWTK 485
Length:485
Mass (Da):53,938
Last modified:June 1, 2002 - v1
Checksum:iB53EB282A21B93CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23589.1.
RefSeqiNP_621985.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23589; AAM23589; TTE0293.
GeneIDi996270.
KEGGitte:TTE0293.
PATRICi23895223. VBITheTen82880_0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23589.1 .
RefSeqi NP_621985.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RCW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23589 ; AAM23589 ; TTE0293 .
GeneIDi 996270.
KEGGi tte:TTE0293.
PATRICi 23895223. VBITheTen82880_0287.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiGCSPB_THETN
AccessioniPrimary (citable) accession number: Q8RCW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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