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Q8RCW1

- GCSPA_THETN

UniProt

Q8RCW1 - GCSPA_THETN

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, gcvP2, TTE0294
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-536-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Synonyms:gcvP2
Ordered Locus Names:TTE0294
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_0000166981Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi273068.TTE0294.

Structurei

3D structure databases

ProteinModelPortaliQ8RCW1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RCW1-1 [UniParc]FASTAAdd to Basket

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MIVMFPYLPI SSEDEKEMLK TIGKNSIEEL FEVIPKEVRL NRPLNLGKPM    50
SELEVRKRLG SYADENKNLS QLVSFLGAGV YDHYIPSVVK HIISRSEFYT 100
AYTPYQPEIS QGTLQAIFEY QTMITNLTGM EVTNASMYDG ASACAEAAMM 150
ACDATKRKSI IVSKTVNPET RKVLKTYMHF KEVEVVEIED ADGVTDIEKL 200
KEVIGPNTAA VIVQYPNFFG IIENLQEIEK ITHEQKAMLI TYVHPIPLGI 250
LKSPGEIGAD IAVGDGQSLG NGLHYGGPYL GFLATTQKLL RRMPGRIVGQ 300
TKDVDGKRGF VLTLQAREQH IRREKATSNI CSNHSLNALT AAVYLATIGK 350
KGIKEVAYQC LQKAHYAYTV LTESGKYKPA FNKPFFMEFA LKTDKDVAEI 400
NKKLLEEGIL GGYDLQRDYE KYKNVMLLAF TEKRTKEEID RLKSLLEVM 449
Length:449
Mass (Da):50,421
Last modified:June 1, 2002 - v1
Checksum:i462A879D75F87EE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23590.1.
RefSeqiNP_621986.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23590; AAM23590; TTE0294.
GeneIDi997934.
KEGGitte:TTE0294.
PATRICi23895225. VBITheTen82880_0288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23590.1 .
RefSeqi NP_621986.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RCW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23590 ; AAM23590 ; TTE0294 .
GeneIDi 997934.
KEGGi tte:TTE0294.
PATRICi 23895225. VBITheTen82880_0288.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CSUB273068:GJEB-536-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiGCSPA_THETN
AccessioniPrimary (citable) accession number: Q8RCW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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