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Protein

Glycine cleavage system H protein 2

Gene

gcvH2

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H protein 2UniRule annotation
Gene namesi
Name:gcvH2UniRule annotation
Ordered Locus Names:TTE0295
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001662601 – 126Glycine cleavage system H protein 2Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-lipoyllysineUniRule annotation1

Proteomic databases

PRIDEiQ8RCW0.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE0295.

Structurei

3D structure databases

ProteinModelPortaliQ8RCW0.
SMRiQ8RCW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 103Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiENOG4105KE9. Bacteria.
COG0509. LUCA.
HOGENOMiHOG000239392.
KOiK02437.
OMAiIVYVEVE.
OrthoDBiPOG091H04TZ.

Family and domain databases

CDDicd06848. GCS_H. 1 hit.
HAMAPiMF_00272. GcvH. 1 hit.
InterProiView protein in InterPro
IPR000089. Biotin_lipoyl.
IPR002930. GCV_H.
IPR033753. GCV_H/Fam206.
IPR017453. GCV_H_sub.
IPR011053. Single_hybrid_motif.
PANTHERiPTHR11715. PTHR11715. 1 hit.
PfamiView protein in Pfam
PF01597. GCV_H. 1 hit.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00527. gcvH. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RCW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVLEGLYYS KDHEWVKVEG DKVYIGITDY AQHSLGNIVY VELPEVGSEL
60 70 80 90 100
SAGDVLGVVE SVKAASDVYT PVDIKVLEVN NSLVEDPSLI NNDPYGSWMV
110 120
IAELKDKSQL DKLMKADEYR KFLEEE
Length:126
Mass (Da):14,158
Last modified:June 1, 2002 - v1
Checksum:iA485C9D6AD9F9134
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23591.1.
RefSeqiWP_011024758.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23591; AAM23591; TTE0295.
KEGGitte:TTE0295.

Similar proteinsi

Entry informationi

Entry nameiGCSH2_CALS4
AccessioniPrimary (citable) accession number: Q8RCW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families