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Q8RCT6

- SYL_THETN

UniProt

Q8RCT6 - SYL_THETN

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Protein

Leucine--tRNA ligase

Gene
leuS, TTE0324
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei581 – 5811ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:TTE0324
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligaseUniRule annotationPRO_0000152107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE0324.

Structurei

3D structure databases

ProteinModelPortaliQ8RCT6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5312"HIGH" regionUniRule annotationAdd
BLAST
Motifi578 – 5825"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RCT6-1 [UniParc]FASTAAdd to Basket

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MEDMAYSVEI DRKWQKIWEE TKLYKFNPEN VDKKLYCLEM FPYPSGAKLH    50
IGHWYNYGPT DSWARMKRMQ GYEVFHPMGF DAFGLPAENY AIKTGIHPYD 100
STMENIRTME RQLREMGVTF DWDYEIITCL PEYYKWTQWI FLKLYEAGLA 150
YRKKAPVNWC PSCQTVLANE QVIDGKCERC GTEVTKKELT QWFFKITAYA 200
EELLEKLDDL DWPEKTKMMQ RNWIGKSEGA EIEFKIDGKD LSFRVFTTRA 250
DTLFGATYVV LAPEHELVDL ITTEEYKEAV EEYKEYAKKQ SEIERLSTEK 300
EKTGVFTGAY AIHPLTGEKL PIWIADYVLV TYGTGCVMGV PGHDERDYEF 350
ATKYNLPIKR VIKGVGDVDD SLPFVEYGIL VNSEEFTGMT SEEARVKIVE 400
KLKAEGKAEF KVNYRMRDWL VSRQRYWGAP IPIIHCERCG IVPVPEEDLP 450
VLLPYDVEFE PTGESPLKKH AGFMNVTCPK CGGPALRDPD TLDTFVDSSW 500
YYLRYPDNKN DKEPFNKEWI NKMLPVDKYV GGAEHATMHL LYSRFITKVL 550
RDLGYLNFDE PFLSLVHQGT ILGPDGSRMS KSRGNVISPD DYIKQYGSDV 600
FRLYLMFGFS YSEGGPWSDE GIKAIARFVN RVERFIEKFI ETRQNPGKTK 650
EEMEDAEKEL NYVRHYTIKH VTLDADKFEF NTAIARIMEL VNALYKYENE 700
VEVKNMKFYE DVVRDFVKIL APFAPHFSEE MWERLGYEYS VFNQKWPEWD 750
EKALERDMIE IAIQVNGKVR SKAQVPSNAT DEELKQIALS DERVKSYLDG 800
KEIKKVIIVK NRLVNIVVN 819
Length:819
Mass (Da):95,501
Last modified:June 1, 2002 - v1
Checksum:i7D9CB46702513E83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23616.1.
RefSeqiNP_622012.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23616; AAM23616; TTE0324.
GeneIDi996294.
KEGGitte:TTE0324.
PATRICi23895281. VBITheTen82880_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23616.1 .
RefSeqi NP_622012.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RCT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23616 ; AAM23616 ; TTE0324 .
GeneIDi 996294.
KEGGi tte:TTE0324.
PATRICi 23895281. VBITheTen82880_0316.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSUB273068:GJEB-586-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiSYL_THETN
AccessioniPrimary (citable) accession number: Q8RCT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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