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Q8RCT6

- SYL_CALS4

UniProt

Q8RCT6 - SYL_CALS4

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei581 – 5811ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TTE0324
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligasePRO_0000152107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE0324.

Structurei

3D structure databases

ProteinModelPortaliQ8RCT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5312"HIGH" regionAdd
BLAST
Motifi578 – 5825"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RCT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDMAYSVEI DRKWQKIWEE TKLYKFNPEN VDKKLYCLEM FPYPSGAKLH
60 70 80 90 100
IGHWYNYGPT DSWARMKRMQ GYEVFHPMGF DAFGLPAENY AIKTGIHPYD
110 120 130 140 150
STMENIRTME RQLREMGVTF DWDYEIITCL PEYYKWTQWI FLKLYEAGLA
160 170 180 190 200
YRKKAPVNWC PSCQTVLANE QVIDGKCERC GTEVTKKELT QWFFKITAYA
210 220 230 240 250
EELLEKLDDL DWPEKTKMMQ RNWIGKSEGA EIEFKIDGKD LSFRVFTTRA
260 270 280 290 300
DTLFGATYVV LAPEHELVDL ITTEEYKEAV EEYKEYAKKQ SEIERLSTEK
310 320 330 340 350
EKTGVFTGAY AIHPLTGEKL PIWIADYVLV TYGTGCVMGV PGHDERDYEF
360 370 380 390 400
ATKYNLPIKR VIKGVGDVDD SLPFVEYGIL VNSEEFTGMT SEEARVKIVE
410 420 430 440 450
KLKAEGKAEF KVNYRMRDWL VSRQRYWGAP IPIIHCERCG IVPVPEEDLP
460 470 480 490 500
VLLPYDVEFE PTGESPLKKH AGFMNVTCPK CGGPALRDPD TLDTFVDSSW
510 520 530 540 550
YYLRYPDNKN DKEPFNKEWI NKMLPVDKYV GGAEHATMHL LYSRFITKVL
560 570 580 590 600
RDLGYLNFDE PFLSLVHQGT ILGPDGSRMS KSRGNVISPD DYIKQYGSDV
610 620 630 640 650
FRLYLMFGFS YSEGGPWSDE GIKAIARFVN RVERFIEKFI ETRQNPGKTK
660 670 680 690 700
EEMEDAEKEL NYVRHYTIKH VTLDADKFEF NTAIARIMEL VNALYKYENE
710 720 730 740 750
VEVKNMKFYE DVVRDFVKIL APFAPHFSEE MWERLGYEYS VFNQKWPEWD
760 770 780 790 800
EKALERDMIE IAIQVNGKVR SKAQVPSNAT DEELKQIALS DERVKSYLDG
810
KEIKKVIIVK NRLVNIVVN
Length:819
Mass (Da):95,501
Last modified:June 1, 2002 - v1
Checksum:i7D9CB46702513E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23616.1.
RefSeqiNP_622012.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23616; AAM23616; TTE0324.
GeneIDi996294.
KEGGitte:TTE0324.
PATRICi23895281. VBITheTen82880_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23616.1 .
RefSeqi NP_622012.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RCT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23616 ; AAM23616 ; TTE0324 .
GeneIDi 996294.
KEGGi tte:TTE0324.
PATRICi 23895281. VBITheTen82880_0316.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSUB273068:GJEB-586-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiSYL_CALS4
AccessioniPrimary (citable) accession number: Q8RCT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3