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Q8RCS0 (MTLD_THETN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:TTE0342
OrganismThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]
Taxonomic identifier273068 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Caldanaerobacter

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_0000170728

Regions

Nucleotide binding4 – 1512NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RCS0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 251DDC8448736BEC

FASTA38644,022
        10         20         30         40         50         60 
MLKALHFGAG NIGRGFIGYL LNKSGYEVTF VDISKEIVDN INKYKKYNVI ILKEPVEKEE 

        70         80         90        100        110        120 
VKEVKALHLE EEDKVLDAFL EADMVTTSVG VSNLSSIGGR LKKYLKARKE KNEKPLDIMA 

       130        140        150        160        170        180 
CENALFATDV LRERVVKEED DDFITYLNLK VGFPNTAVDR IVPAVKIDKK LPVDVAVEEF 

       190        200        210        220        230        240 
FEWDIEKNKI KGNLQIEGVE LVDDLKPYIE RKLFLLNGAH ATTAYLGYLR GYTYIHQAIK 

       250        260        270        280        290        300 
DDNIRAIVKG MQEEISTALS KKYDVDKESL MAYAEKVIKR FENPYLQDEV TRVGREPLRK 

       310        320        330        340        350        360 
LSSEDRLIAP LKLCSEVGIT PNFILYGIAA GLLFDYKEDA QAVKMREYVE QFGIKKAVNV 

       370        380 
ITGLEEESDL VEEIEKRYFE LKGKLI

« Hide

References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE008691 Genomic DNA. Translation: AAM23634.1.
RefSeqNP_622030.1. NC_003869.1.

3D structure databases

ProteinModelPortalQ8RCS0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID996309.
GenomeReviewsGene locus TTE0342 in contig AE008691_GR.
KEGGtte:TTE0342.
NMPDRfig|273068.3.peg.188.
PATRIC23895321. VBITheTen82880_0336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG568825.
OMAMACENAL.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycTTEN273068:TTE0342-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_THETN
AccessionPrimary (citable) accession number: Q8RCS0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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