Reviewed, UniProtKB/Swiss-Prot Q8RCS0 (MTLD_THETN)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	TTE0342

Organism

Thermoanaerobacter tengcongensis [Complete proteome] [HAMAP]

Taxonomic identifier

119072 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170728
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8RCS0-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 251DDC8448736BEC	FASTA	386	44,022
	10 20 30 40 50 60 MLKALHFGAG NIGRGFIGYL LNKSGYEVTF VDISKEIVDN INKYKKYNVI ILKEPVEKEE 70 80 90 100 110 120 VKEVKALHLE EEDKVLDAFL EADMVTTSVG VSNLSSIGGR LKKYLKARKE KNEKPLDIMA 130 140 150 160 170 180 CENALFATDV LRERVVKEED DDFITYLNLK VGFPNTAVDR IVPAVKIDKK LPVDVAVEEF 190 200 210 220 230 240 FEWDIEKNKI KGNLQIEGVE LVDDLKPYIE RKLFLLNGAH ATTAYLGYLR GYTYIHQAIK 250 260 270 280 290 300 DDNIRAIVKG MQEEISTALS KKYDVDKESL MAYAEKVIKR FENPYLQDEV TRVGREPLRK 310 320 330 340 350 360 LSSEDRLIAP LKLCSEVGIT PNFILYGIAA GLLFDYKEDA QAVKMREYVE QFGIKKAVNV 370 380 ITGLEEESDL VEEIEKRYFE LKGKLI

References

[1]

"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013006 Genomic DNA. Translation: AAM23634.1.
RefSeq	NP_622030.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	996309.
GenomeReviews	Gene locus TTE0342 in contig AE008691_GR.
KEGG	tte:TTE0342.
NMPDR	fig|273068.3.peg.188.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8RCS0.
OMA	Q8RCS0. VDRIVPN.
Enzyme and pathway databases
BioCyc	TTEN273068:TTE0342-MON.
BRENDA	1.1.1.17. 276887.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_THETN

Accession

Primary (citable) accession number: Q8RCS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)