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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi881 – 8811ZincUniRule annotation
Metal bindingi883 – 8831ZincUniRule annotation
Metal bindingi892 – 8921ZincUniRule annotation
Metal bindingi893 – 8931ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-937-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:TTE0522
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 898898Protein translocase subunit SecAPRO_0000318477Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE0522.

Structurei

3D structure databases

ProteinModelPortaliQ8RCB4.
SMRiQ8RCB4. Positions 1-856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RCB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLVEKIFG SYSEREVRRL EPIAEKVLSY EDQMARLTDA ELRAKTDEFK
60 70 80 90 100
NRLKNGETLD DILPEAFAVV REAAWRTLKM KHFKVQIIGG IVLHQGRIAE
110 120 130 140 150
MKTGEGKTLV ATLPAYLNAL EGKGVHIVTV NDYLAKRDRD WMGKIYEFLG
160 170 180 190 200
LSVGVILHDM GPAERKKAYA ADITYGTNNE FGFDYLRDNM VIYKEDMVQR
210 220 230 240 250
ELNYAIIDEV DSILIDEART PLIISGVGEK STDMYKLADR FVRTLKKDED
260 270 280 290 300
YVVDEKAKAV SLTEKGVAKA EKFFGIKNLA DIENMEISHH IQQALKAHAI
310 320 330 340 350
MKRDRDYVVK DGQVIIVDEF TGRLMFGRRY SEGLHQAIEA KEGVKVERES
360 370 380 390 400
KTLATITLQN YFRMYKKLAG MTGTAQTEEQ EFRDIYGLDV VVIPTHKPMI
410 420 430 440 450
RIDHPDVIYK TEEAKFRAVV EDIVERHKKG QPVLVGTVSI EKSEKLSAML
460 470 480 490 500
KKRGIPHQVL NAKYHEKEAE IIAQAGRKGA VTIATNMAGR GTDILLGGNP
510 520 530 540 550
EFIAKRKMLE EGYSKEIINE AAGYGPVSSE EVRKARERYF ELLEEAKKET
560 570 580 590 600
EKEHEEVVKL GGLYVIGTER HEARRIDNQL RGRAGRQGDP GESRFYISLE
610 620 630 640 650
DDLMRLFGSE RVKNLMDSLG IDDDQPIEHK ILTKQIEQAQ KKVEGINFDI
660 670 680 690 700
RKHLLQYDDV MNKQREIIYA QRRKVLEGEN LKDSILEMVR SIIERYVEIY
710 720 730 740 750
TAGSKYPEEW DIKGLLDHLY EMFLEKDSVV IDVDLDRLDK EVLTDIIYEE
760 770 780 790 800
AVRQYERKEA EIGPEQMREI ERIVLLRVVD TKWMDHIDEM DQLRQGIGLR
810 820 830 840 850
AYGQVDPLIE YKKIAFDMFE DLIHSIQEDT VKFLYRIQVN KDNKLKREQV
860 870 880 890
AKPVSTNING EGDNKKQPVV KEKKVGRNDP CPCGSGKKYK KCCGANVK
Length:898
Mass (Da):103,084
Last modified:February 5, 2008 - v2
Checksum:i8FF75FD75BC13058
GO

Sequence cautioni

The sequence AAM23798 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23798.1. Different initiation.
RefSeqiWP_031314145.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23798; AAM23798; TTE0522.
KEGGitte:TTE0522.
PATRICi23895698. VBITheTen82880_0521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23798.1. Different initiation.
RefSeqiWP_031314145.1. NC_003869.1.

3D structure databases

ProteinModelPortaliQ8RCB4.
SMRiQ8RCB4. Positions 1-856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273068.TTE0522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM23798; AAM23798; TTE0522.
KEGGitte:TTE0522.
PATRICi23895698. VBITheTen82880_0521.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-937-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_CALS4
AccessioniPrimary (citable) accession number: Q8RCB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.