Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (PurB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-1057-MONOMER.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:TTE0588
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Phosphoribosylaminoimidazole-succinocarboxamide synthasePRO_0000100892Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE0588.

Structurei

3D structure databases

ProteinModelPortaliQ8RC58.
SMRiQ8RC58. Positions 2-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OrthoDBiEOG62C9HN.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKELLYEG KAKKVYKTDK EDYYIIEYKD DATAFNGLKK GVIEEKGVVN
60 70 80 90 100
NKVSSILFEF LEKRGIPTHY VKMLKDREML VKKVTIFPLE VIIRNYAAGS
110 120 130 140 150
ICKRLGLQEG IKFKEPVLEF CYKNDELGDP MINEYHIRAL ELATRDEIDL
160 170 180 190 200
IKERAFKVNE ILSEYFLSKD IILVDFKLEF GKNQEGILLA DEISPDTCRF
210 220 230
WDKNTMEKLD KDRFRKDLGQ VEEAYLEILR RVQQV
Length:235
Mass (Da):27,654
Last modified:July 26, 2002 - v2
Checksum:iECB63958386FCF8A
GO

Sequence cautioni

The sequence AAM23859.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23859.1. Different initiation.
RefSeqiWP_011025004.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23859; AAM23859; TTE0588.
KEGGitte:TTE0588.
PATRICi23895838. VBITheTen82880_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23859.1. Different initiation.
RefSeqiWP_011025004.1. NC_003869.1.

3D structure databases

ProteinModelPortaliQ8RC58.
SMRiQ8RC58. Positions 2-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273068.TTE0588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM23859; AAM23859; TTE0588.
KEGGitte:TTE0588.
PATRICi23895838. VBITheTen82880_0590.

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
KOiK01923.
OrthoDBiEOG62C9HN.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.
BioCyciCSUB273068:GJEB-1057-MONOMER.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiPS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiPUR7_CALS4
AccessioniPrimary (citable) accession number: Q8RC58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: November 11, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.