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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78Charge relay systemUniRule annotation1
Active sitei153Charge relay systemUniRule annotation1
Active sitei177Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTEN273068:G1FZJ-635-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-ADT subunit AUniRule annotation
Gene namesi
Name:gatAUniRule annotation
Ordered Locus Names:TTE0607
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001052231 – 488Glutamyl-tRNA(Gln) amidotransferase subunit AAdd BLAST488

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE0607

Structurei

3D structure databases

ProteinModelPortaliQ8RC40
SMRiQ8RC40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3P Bacteria
COG0154 LUCA
HOGENOMiHOG000116699
KOiK02433
OMAiPITQNVE
OrthoDBiPOG091H00O9

Family and domain databases

Gene3Di3.90.1300.10, 1 hit
HAMAPiMF_00120 GatA, 1 hit
InterProiView protein in InterPro
IPR000120 Amidase
IPR020556 Amidase_CS
IPR023631 Amidase_dom
IPR036928 AS_sf
IPR004412 GatA
PANTHERiPTHR11895 PTHR11895, 1 hit
PfamiView protein in Pfam
PF01425 Amidase, 1 hit
SUPFAMiSSF75304 SSF75304, 1 hit
TIGRFAMsiTIGR00132 gatA, 1 hit
PROSITEiView protein in PROSITE
PS00571 AMIDASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q8RC40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELYSLTVHE LKELLHKREV SAQEVTKSYL ERIKEVEPKI DALVTITEEF
60 70 80 90 100
ALERAKVADE MIKNGEAKDL TGIPVIIKDN ISTEGIRTTC SSKMLENYIP
110 120 130 140 150
PYNATVVERL LNEGVVILGK SNLDEFAMGS STENSAFKTT KNPWDLSRVP
160 170 180 190 200
GGSSGGSAAA VAADEAAFAL GSDTGGSIRQ PASLCGVVGM KPTYGLVSRY
210 220 230 240 250
GLVAFASSLD QIGPFTKDVT DCAIVLNAIA GHDPMDSTSV KIEKPDYTSY
260 270 280 290 300
LKEDIKGLRI GVAKEFFGAG IEEGVKETVE KAIKVFEDLG AEIIDISVPY
310 320 330 340 350
VEYALPAYYI IASAEASSNL ARYDGIRYGH IAKNYEDLVD MYMTSRSEGF
360 370 380 390 400
GKEVKRRIML GTYALSSGYY DAYYKKALKV RTLIKNDFER AFEKCDVIVG
410 420 430 440 450
PTSPTVAFKI GERTNDPLAM YLADIYTVSV NIAGLPAISI PCGLSEGLPV
460 470 480
GLQIIGKHFD EGRILNVAYA FEKAYKFDAK PQAIGGER
Length:488
Mass (Da):53,139
Last modified:June 1, 2002 - v1
Checksum:i5902CB61E0622B08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA Translation: AAM23877.1
RefSeqiWP_011025022.1, NC_003869.1

Genome annotation databases

EnsemblBacteriaiAAM23877; AAM23877; TTE0607
KEGGitte:TTE0607

Similar proteinsi

Entry informationi

Entry nameiGATA_CALS4
AccessioniPrimary (citable) accession number: Q8RC40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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