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Q8RBX6

- Q8RBX6_THETN

UniProt

Q8RBX6 - Q8RBX6_THETN

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Protein
Submitted name:

Methyl-accepting chemotaxis protein

Gene
Tar4, TTE0680
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron (heme axial ligand); via tele nitrogenImported

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

HemeImported, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Methyl-accepting chemotaxis proteinImported
Gene namesi
Name:Tar4Imported
Ordered Locus Names:TTE0680Imported
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)Imported
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE0680.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U4HX-ray2.07A/B1-188[»]
1U55X-ray1.77A/B1-188[»]
1U56X-ray1.90A/B1-188[»]
1XBNX-ray2.50A1-191[»]
3EEEX-ray2.12A/B/C/D1-188[»]
3IQBX-ray2.10A1-188[»]
3LAHX-ray2.00A/B1-188[»]
3LAIX-ray2.14A/B/C1-188[»]
3M0BX-ray2.00A1-188[»]
3NVRX-ray2.15A/B1-188[»]
3NVUX-ray2.04A/B1-188[»]
3SJ5X-ray1.67A/B1-188[»]
3TF0X-ray1.74A/B1-188[»]
3TF1X-ray2.04A/B1-188[»]
4FDKX-ray2.10A/B1-188[»]
4IT2X-ray2.10A/B1-188[»]
ProteinModelPortaliQ8RBX6.
SMRiQ8RBX6. Positions 1-188.

Miscellaneous databases

EvolutionaryTraceiQ8RBX6.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000055038.
KOiK03406.
OMAiFSKWFPS.
OrthoDBiEOG6FRCT2.

Family and domain databases

InterProiIPR011644. Heme_NO-bd.
IPR004089. MCPsignal_dom.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view]
PfamiPF07700. HNOB. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
SMARTiSM00283. MA. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.
PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RBX6-1 [UniParc]FASTAAdd to Basket

« Hide

MKGTIVGTWI KTLRDLYGND VVDESLKSVG WEPDRVITPL EDIDDDEVRR    50
IFAKVSEKTG KNVNEIWREV GRQNIKTFSE WFPSYFAGRR LVNFLMMMDE 100
VHLQLTKMIK GATPPRLIAK PVAKDAIEME YVSKRKMYDY FLGLIEGSSK 150
FFKEEISVEE VERGEKDGFS RLKVRIKFKN PVFEYKKNVW GKILGFGFIR 200
SNSFKLALWS FIIGFLVVGF VSSWDLLKSF SGAFIIGAFT YIFSYILNMP 250
AKNLHEFVKI MGSRNLEEEF KLESGDVFEA IAEELNSVKD TIKKDMLFLK 300
GGTDDMHNFV HRFNEIAENM KKVSEDISSV VNDVASSTVH QAEEIERAVG 350
ILDENIKKIN EIAGTSKESN EKLENSIENI KRANTDVTDV AKELSQVEVD 400
FSSIYEMGKV LSDSAKDIMA IVTTVEEISD QTNLLALNAA IEAARAGEAG 450
RGFAVVAEEV RNLAENSKNA VKTITESLVN FTGQVENLAE KISAQFERLK 500
KSISTLEKVV EKNTMATEEV AGISSVIVES ANRLYEEAEK LSEVFGHLEN 550
LAAISEENSA SSEEMSANVT EYSNRIREFI EQIKQMETLV TNFKKELDKY 600
KV 602
Length:602
Mass (Da):68,053
Last modified:June 1, 2002 - v1
Checksum:i6CD008747FCBC22E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23944.1.
RefSeqiNP_622340.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM23944; AAM23944; TTE0680.
GeneIDi996654.
KEGGitte:TTE0680.
PATRICi23896032. VBITheTen82880_0678.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM23944.1 .
RefSeqi NP_622340.1. NC_003869.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1U4H X-ray 2.07 A/B 1-188 [» ]
1U55 X-ray 1.77 A/B 1-188 [» ]
1U56 X-ray 1.90 A/B 1-188 [» ]
1XBN X-ray 2.50 A 1-191 [» ]
3EEE X-ray 2.12 A/B/C/D 1-188 [» ]
3IQB X-ray 2.10 A 1-188 [» ]
3LAH X-ray 2.00 A/B 1-188 [» ]
3LAI X-ray 2.14 A/B/C 1-188 [» ]
3M0B X-ray 2.00 A 1-188 [» ]
3NVR X-ray 2.15 A/B 1-188 [» ]
3NVU X-ray 2.04 A/B 1-188 [» ]
3SJ5 X-ray 1.67 A/B 1-188 [» ]
3TF0 X-ray 1.74 A/B 1-188 [» ]
3TF1 X-ray 2.04 A/B 1-188 [» ]
4FDK X-ray 2.10 A/B 1-188 [» ]
4IT2 X-ray 2.10 A/B 1-188 [» ]
ProteinModelPortali Q8RBX6.
SMRi Q8RBX6. Positions 1-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE0680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM23944 ; AAM23944 ; TTE0680 .
GeneIDi 996654.
KEGGi tte:TTE0680.
PATRICi 23896032. VBITheTen82880_0678.

Phylogenomic databases

HOGENOMi HOG000055038.
KOi K03406.
OMAi FSKWFPS.
OrthoDBi EOG6FRCT2.

Miscellaneous databases

EvolutionaryTracei Q8RBX6.

Family and domain databases

InterProi IPR011644. Heme_NO-bd.
IPR004089. MCPsignal_dom.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
[Graphical view ]
Pfami PF07700. HNOB. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view ]
SMARTi SM00283. MA. 1 hit.
[Graphical view ]
SUPFAMi SSF111126. SSF111126. 1 hit.
PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.
  2. "Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases."
    Pellicena P., Karow D.S., Boon E.M., Marletta M.A., Kuriyan J.
    Proc. Natl. Acad. Sci. U.S.A. 101:12854-12859(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
  3. "Femtomolar sensitivity of a NO sensor from Clostridium botulinum."
    Nioche P., Berka V., Vipond J., Minton N., Tsai A.L., Raman C.S.
    Science 306:1550-1553(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-191 IN COMPLEX WITH HEME.
  4. "Probing the function of heme distortion in the H-NOX family."
    Olea C., Boon E.M., Pellicena P., Kuriyan J., Marletta M.A.
    ACS Chem. Biol. 3:703-710(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
  5. "Determinants of ligand affinity and heme reactivity in H-NOX domains."
    Weinert E.E., Plate L., Whited C.A., Olea C., Marletta M.A.
    Angew. Chem. Int. Ed. 49:720-723(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-188.
  7. "Modulating heme redox potential through protein-induced porphyrin distortion."
    Olea C., Kuriyan J., Marletta M.A.
    J. Am. Chem. Soc. 132:12794-12795(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
  8. "Structural insights into the molecular mechanism of H-NOX activation."
    Olea C., Herzik M.A., Kuriyan J., Marletta M.A.
    Protein Sci. 19:881-887(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-188.
  9. "Controlling conformational flexibility of an O2-binding H-NOX domain."
    Weinert E.E., Phillips-Piro C.M., Tran R., Mathies R.A., Marletta M.A.
    Biochemistry 50:6832-6840(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
  10. "Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain."
    Winter M.B., Herzik M.A., Kuriyan J., Marletta M.A.
    Proc. Natl. Acad. Sci. U.S.A. 108:E881-E889(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
  11. "Porphyrin-substituted H-NOX proteins as high-relaxivity MRI contrast agents."
    Winter M.B., Klemm P.J., Phillips-Piro C.M., Raymond K.N., Marletta M.A.
    Inorg. Chem. 52:2277-2279(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-188.
  12. "Porphyrin ?-stacking in a heme protein scaffold tunes gas ligand affinity."
    Weinert E.E., Phillips-Piro C.M., Marletta M.A.
    J. Inorg. Biochem. 127:7-12(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.

Entry informationi

Entry nameiQ8RBX6_THETN
AccessioniPrimary (citable) accession number: Q8RBX6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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