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Q8RBX6

- Q8RBX6_THETN

UniProt

Q8RBX6 - Q8RBX6_THETN

Protein
Submitted name:

Methyl-accepting chemotaxis protein

Gene

Tar4

Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Iron (heme axial ligand); via tele nitrogenImported

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. signal transducer activity Source: InterPro

    Keywords - Ligandi

    HemeImported, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Methyl-accepting chemotaxis proteinImported
    Gene namesi
    Name:Tar4Imported
    Ordered Locus Names:TTE0680Imported
    OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)Imported
    Taxonomic identifieri273068 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
    ProteomesiUP000000555: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi273068.TTE0680.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1U4HX-ray2.07A/B1-188[»]
    1U55X-ray1.77A/B1-188[»]
    1U56X-ray1.90A/B1-188[»]
    1XBNX-ray2.50A1-191[»]
    3EEEX-ray2.12A/B/C/D1-188[»]
    3IQBX-ray2.10A1-188[»]
    3LAHX-ray2.00A/B1-188[»]
    3LAIX-ray2.14A/B/C1-188[»]
    3M0BX-ray2.00A1-188[»]
    3NVRX-ray2.15A/B1-188[»]
    3NVUX-ray2.04A/B1-188[»]
    3SJ5X-ray1.67A/B1-188[»]
    3TF0X-ray1.74A/B1-188[»]
    3TF1X-ray2.04A/B1-188[»]
    4FDKX-ray2.10A/B1-188[»]
    4IT2X-ray2.10A/B1-188[»]
    ProteinModelPortaliQ8RBX6.
    SMRiQ8RBX6. Positions 1-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8RBX6.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000055038.
    KOiK03406.
    OMAiFSKWFPS.
    OrthoDBiEOG6FRCT2.

    Family and domain databases

    InterProiIPR011644. Heme_NO-bd.
    IPR004089. MCPsignal_dom.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view]
    PfamiPF07700. HNOB. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view]
    SMARTiSM00283. MA. 1 hit.
    [Graphical view]
    SUPFAMiSSF111126. SSF111126. 1 hit.
    PROSITEiPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RBX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGTIVGTWI KTLRDLYGND VVDESLKSVG WEPDRVITPL EDIDDDEVRR    50
    IFAKVSEKTG KNVNEIWREV GRQNIKTFSE WFPSYFAGRR LVNFLMMMDE 100
    VHLQLTKMIK GATPPRLIAK PVAKDAIEME YVSKRKMYDY FLGLIEGSSK 150
    FFKEEISVEE VERGEKDGFS RLKVRIKFKN PVFEYKKNVW GKILGFGFIR 200
    SNSFKLALWS FIIGFLVVGF VSSWDLLKSF SGAFIIGAFT YIFSYILNMP 250
    AKNLHEFVKI MGSRNLEEEF KLESGDVFEA IAEELNSVKD TIKKDMLFLK 300
    GGTDDMHNFV HRFNEIAENM KKVSEDISSV VNDVASSTVH QAEEIERAVG 350
    ILDENIKKIN EIAGTSKESN EKLENSIENI KRANTDVTDV AKELSQVEVD 400
    FSSIYEMGKV LSDSAKDIMA IVTTVEEISD QTNLLALNAA IEAARAGEAG 450
    RGFAVVAEEV RNLAENSKNA VKTITESLVN FTGQVENLAE KISAQFERLK 500
    KSISTLEKVV EKNTMATEEV AGISSVIVES ANRLYEEAEK LSEVFGHLEN 550
    LAAISEENSA SSEEMSANVT EYSNRIREFI EQIKQMETLV TNFKKELDKY 600
    KV 602
    Length:602
    Mass (Da):68,053
    Last modified:June 1, 2002 - v1
    Checksum:i6CD008747FCBC22E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM23944.1.
    RefSeqiNP_622340.1. NC_003869.1.

    Genome annotation databases

    EnsemblBacteriaiAAM23944; AAM23944; TTE0680.
    GeneIDi996654.
    KEGGitte:TTE0680.
    PATRICi23896032. VBITheTen82880_0678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM23944.1 .
    RefSeqi NP_622340.1. NC_003869.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1U4H X-ray 2.07 A/B 1-188 [» ]
    1U55 X-ray 1.77 A/B 1-188 [» ]
    1U56 X-ray 1.90 A/B 1-188 [» ]
    1XBN X-ray 2.50 A 1-191 [» ]
    3EEE X-ray 2.12 A/B/C/D 1-188 [» ]
    3IQB X-ray 2.10 A 1-188 [» ]
    3LAH X-ray 2.00 A/B 1-188 [» ]
    3LAI X-ray 2.14 A/B/C 1-188 [» ]
    3M0B X-ray 2.00 A 1-188 [» ]
    3NVR X-ray 2.15 A/B 1-188 [» ]
    3NVU X-ray 2.04 A/B 1-188 [» ]
    3SJ5 X-ray 1.67 A/B 1-188 [» ]
    3TF0 X-ray 1.74 A/B 1-188 [» ]
    3TF1 X-ray 2.04 A/B 1-188 [» ]
    4FDK X-ray 2.10 A/B 1-188 [» ]
    4IT2 X-ray 2.10 A/B 1-188 [» ]
    ProteinModelPortali Q8RBX6.
    SMRi Q8RBX6. Positions 1-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273068.TTE0680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM23944 ; AAM23944 ; TTE0680 .
    GeneIDi 996654.
    KEGGi tte:TTE0680.
    PATRICi 23896032. VBITheTen82880_0678.

    Phylogenomic databases

    HOGENOMi HOG000055038.
    KOi K03406.
    OMAi FSKWFPS.
    OrthoDBi EOG6FRCT2.

    Miscellaneous databases

    EvolutionaryTracei Q8RBX6.

    Family and domain databases

    InterProi IPR011644. Heme_NO-bd.
    IPR004089. MCPsignal_dom.
    IPR024096. NO_sig/Golgi_transp_ligand-bd.
    [Graphical view ]
    Pfami PF07700. HNOB. 1 hit.
    PF00015. MCPsignal. 1 hit.
    [Graphical view ]
    SMARTi SM00283. MA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111126. SSF111126. 1 hit.
    PROSITEi PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4Imported.
    2. "Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases."
      Pellicena P., Karow D.S., Boon E.M., Marletta M.A., Kuriyan J.
      Proc. Natl. Acad. Sci. U.S.A. 101:12854-12859(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
    3. "Femtomolar sensitivity of a NO sensor from Clostridium botulinum."
      Nioche P., Berka V., Vipond J., Minton N., Tsai A.L., Raman C.S.
      Science 306:1550-1553(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-191 IN COMPLEX WITH HEME.
    4. "Probing the function of heme distortion in the H-NOX family."
      Olea C., Boon E.M., Pellicena P., Kuriyan J., Marletta M.A.
      ACS Chem. Biol. 3:703-710(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
    5. "Determinants of ligand affinity and heme reactivity in H-NOX domains."
      Weinert E.E., Plate L., Whited C.A., Olea C., Marletta M.A.
      Angew. Chem. Int. Ed. 49:720-723(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-188.
    7. "Modulating heme redox potential through protein-induced porphyrin distortion."
      Olea C., Kuriyan J., Marletta M.A.
      J. Am. Chem. Soc. 132:12794-12795(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
    8. "Structural insights into the molecular mechanism of H-NOX activation."
      Olea C., Herzik M.A., Kuriyan J., Marletta M.A.
      Protein Sci. 19:881-887(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-188.
    9. "Controlling conformational flexibility of an O2-binding H-NOX domain."
      Weinert E.E., Phillips-Piro C.M., Tran R., Mathies R.A., Marletta M.A.
      Biochemistry 50:6832-6840(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
    10. "Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain."
      Winter M.B., Herzik M.A., Kuriyan J., Marletta M.A.
      Proc. Natl. Acad. Sci. U.S.A. 108:E881-E889(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.
    11. "Porphyrin-substituted H-NOX proteins as high-relaxivity MRI contrast agents."
      Winter M.B., Klemm P.J., Phillips-Piro C.M., Raymond K.N., Marletta M.A.
      Inorg. Chem. 52:2277-2279(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-188.
    12. "Porphyrin ?-stacking in a heme protein scaffold tunes gas ligand affinity."
      Weinert E.E., Phillips-Piro C.M., Marletta M.A.
      J. Inorg. Biochem. 127:7-12(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 1-188 IN COMPLEX WITH HEME.

    Entry informationi

    Entry nameiQ8RBX6_THETN
    AccessioniPrimary (citable) accession number: Q8RBX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3