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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177UniRule annotation1
Active sitei204UniRule annotation1
Active sitei303UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:TTE1035
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580331 – 367Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE1035.

Structurei

3D structure databases

ProteinModelPortaliQ8RAZ3.
SMRiQ8RAZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini165 – 361CheB-type methylesteraseUniRule annotationAdd BLAST197

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiAMVKIRQ.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RAZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKIRVLVV DDSAFMRRCL KDILENEEDM EVIDTARDGN EAVKKAVELR
60 70 80 90 100
PDVITLDINM PVMDGLTALQ YIMSLAPCPV VIISSLSTEG ALTTFEALEL
110 120 130 140 150
GAVDFVAKPG GTVSLGIKQL ADEIVSKVRI AALSNKELLS SSRNFKKLLK
160 170 180 190 200
RRNQEVTRKV YENKISKKEI VVVIGVSTGG PKTLMEILPY LPSDFPAAVL
210 220 230 240 250
VVQHMPPGFT QSFAQRLDQS CNLKVKEAED KAFIEPGTVI IAKGGWHLVV
260 270 280 290 300
ERDSRSSKLI TRLTQKPEET LYKPSINVTM KSVLENVDGR NIIGILLTGM
310 320 330 340 350
GDDGADMMVE IRKRGGLTIA ESQETAIVYG MPRAAVERGG AEIVAPAYKI
360
SDILLKKVNE YARTSEY
Length:367
Mass (Da):40,350
Last modified:June 1, 2002 - v1
Checksum:i612272BBC543DEA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM24289.1.
RefSeqiWP_011025403.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM24289; AAM24289; TTE1035.
KEGGitte:TTE1035.

Similar proteinsi

Entry informationi

Entry nameiCHEB_CALS4
AccessioniPrimary (citable) accession number: Q8RAZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome