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Protein

Alanine racemase 1

Gene

alr1

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase 1 (alr1), Alanine racemase 2 (alr2)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei268Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei316Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTTEN273068:G1FZJ-1298-MONOMER.
BRENDAi5.1.1.1. 6784.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase 1UniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1
Ordered Locus Names:TTE1207
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001145881 – 388Alanine racemase 1Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ8RAK6.

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE1207.

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 14Combined sources7
Helixi15 – 28Combined sources14
Beta strandi34 – 38Combined sources5
Helixi40 – 45Combined sources6
Helixi48 – 58Combined sources11
Beta strandi61 – 67Combined sources7
Helixi68 – 76Combined sources9
Beta strandi83 – 85Combined sources3
Helixi91 – 93Combined sources3
Helixi94 – 99Combined sources6
Beta strandi103 – 106Combined sources4
Helixi109 – 121Combined sources13
Beta strandi126 – 132Combined sources7
Beta strandi134 – 136Combined sources3
Beta strandi138 – 142Combined sources5
Helixi144 – 155Combined sources12
Beta strandi160 – 166Combined sources7
Turni172 – 175Combined sources4
Helixi177 – 195Combined sources19
Turni196 – 198Combined sources3
Beta strandi202 – 208Combined sources7
Helixi209 – 214Combined sources6
Helixi216 – 219Combined sources4
Beta strandi220 – 224Combined sources5
Helixi227 – 230Combined sources4
Beta strandi236 – 238Combined sources3
Beta strandi248 – 253Combined sources6
Beta strandi256 – 260Combined sources5
Beta strandi265 – 267Combined sources3
Helixi268 – 270Combined sources3
Beta strandi278 – 284Combined sources7
Helixi287 – 289Combined sources3
Helixi293 – 295Combined sources3
Beta strandi300 – 303Combined sources4
Beta strandi306 – 312Combined sources7
Beta strandi319 – 322Combined sources4
Beta strandi334 – 340Combined sources7
Helixi348 – 354Combined sources7
Helixi359 – 365Combined sources7
Beta strandi372 – 376Combined sources5
Beta strandi379 – 384Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y2WX-ray2.70A/B1-388[»]
ProteinModelPortaliQ8RAK6.
SMRiQ8RAK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiISHFACA.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8RAK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFDGVRPTR VEVYLDAITH NFREIKKIVG KNVKIMAVIK GDAYGHGASY
60 70 80 90 100
VAKFLEKEGV DYFGVATTEE ALELREKGIK TPILIFGYTP PTQLRQIVKH
110 120 130 140 150
DLTQTVYDIK YAKELEKESL KQNKRAKVHI KIDTGLGRIG YIDFDLAQKE
160 170 180 190 200
ILEMANMRGL ILEGIYSHFA AASEDDRDYC KEQFDKFMNL ISSLEKKRLK
210 220 230 240 250
IPLKHIANAA AILNLNYSHL DMVRPGIILF GAYPSKRVER KVELRETLRF
260 270 280 290 300
TTRVVHLKDV PAGFFIGYGK SFVTKRKSVI ATIPVGYADG LDRRLSNNYK
310 320 330 340 350
LLLKGKYVPI VGRVCMDQCM IDVTDVEGVE IGDEVVIIGT QNNETVSVES
360 370 380
MADKIETIPQ EVFSRISRRV PRVYFYDGIK IGEVNYLK
Length:388
Mass (Da):44,126
Last modified:June 1, 2002 - v1
Checksum:i8D8E10CF5E20DC9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM24437.1.
RefSeqiWP_011025537.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM24437; AAM24437; TTE1207.
KEGGitte:TTE1207.

Similar proteinsi

Entry informationi

Entry nameiALR1_CALS4
AccessioniPrimary (citable) accession number: Q8RAK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome