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Q8RAC3 (NADK_THETN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283NAD kinase HAMAP-Rule MF_00361
PRO_0000120681

Regions

Nucleotide binding68 – 692NAD By similarity
Nucleotide binding142 – 1432NAD By similarity
Nucleotide binding183 – 1886NAD By similarity

Sites

Active site681Proton acceptor By similarity
Binding site1531NAD By similarity
Binding site1721NAD By similarity
Binding site2421NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8RAC3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: CA905F822CF59566

FASTA28331,617
        10         20         30         40         50         60 
MKKVGVIPNI NKDKDLEVTK SVVNWLLDHG SEPYLNEIVA ARIGYEKHGK KANEIYSKSD 

        70         80         90        100        110        120 
FLIALGGDGT ILNVARLCAP FGTPILAVNL GHLGFLTEID ASELFPSLEK IYKGEYAIEK 

       130        140        150        160        170        180 
RMMLEANVVK NDMEVINFRA LNDIVITRGA FSRMARIKAY VNDNYVDTYL ADGVIVATPT 

       190        200        210        220        230        240 
GSTAYSLSAG GPIVYPTVEV IIITPICPHT LYSRSIVVSP DDVIRLEIAE ENQDLMITTD 

       250        260        270        280 
GQQGYKIDYR DVIYIKKSNE YTNLIKVKNS NFFDLLRDKL TER 

« Hide

References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008691 Genomic DNA. Translation: AAM24524.1.
RefSeqNP_622920.1. NC_003869.1.

3D structure databases

ProteinModelPortalQ8RAC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273068.TTE1300.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM24524; AAM24524; TTE1300.
GeneID996870.
KEGGtte:TTE1300.
PATRIC23897311. VBITheTen82880_1309.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMARWEALCL.
OrthoDBEOG6PZXDR.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_THETN
AccessionPrimary (citable) accession number: Q8RAC3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families