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Q8RA71

- MUTS_THETN

UniProt

Q8RA71 - MUTS_THETN

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Protein
DNA mismatch repair protein MutS
Gene
mutS, mutS2, TTE1357
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi619 – 6268ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: UniProtKB-HAMAP
  3. mismatched DNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
Synonyms:mutS2
Ordered Locus Names:TTE1357
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869DNA mismatch repair protein MutSUniRule annotation
PRO_0000115161Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE1357.

Structurei

3D structure databases

ProteinModelPortaliQ8RA71.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiASMRDGG.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RA71-1 [UniParc]FASTAAdd to Basket

« Hide

MLKMSVTPMM EQYLKIKEKY KDAILFFRLG DFYEMFYEDA EIAAKELEIA    50
LTGRDAGTEE RAPMAGVPYH AADFYIDKLV KKGYKVAICE QLEDPSKAKG 100
LVKRDVVRIY TPGTIINPES MDEKSNNYLV SVYREKDNYG ICAVDVTTGE 150
LYATEIKNCK NGKRIYDEIA KYSPSEIISN EEFLKNNKYI KVFKNNNCAV 200
NAYKPLNYEA SSELIEKQFD KKVEELELED KKFVIHSLGA LLSYLKELQK 250
TSLKHINKLT LYQDNSYMGL DSNAIRNLEI LESNRNKSKK GSLLGVLDRT 300
VTPMGGRLLK KWLEEPLIDK DEIEKRLDAV EELFNNYRER IELKELLNKV 350
YDLERLASKI VYQSVTPKDF ISIKLSLQNL PKIKNILSKF SSRLLKEIYE 400
KLDVLQDVYE LIDKSIKDDP SNQLKEGNII KDGYNEMVDK LRKASTEGKN 450
WIANLEADER EKTGIKNLRI GYNKVFGYYI EVTKSNIPQV PDRYIRKQTL 500
ANAERYVTPE LKEIEETILG AEEKLIELEY ELFNEIREKV ELQIVRIQNT 550
AKYIAIIDVL ISFAEVAETN KYVKPIVDYE DRIVIKEGRH PVVETISDEG 600
FVANDIDIGP ENPIMIITGP NMAGKSTYMR QVALIVLMAQ VGCFVPASYA 650
RIGIVDKIFT RVGASDDIFA GQSTFMVEMS EVANILHSAT SKSLIILDEV 700
GRGTSTYDGM SIAQAVIEYI HEKIKAKTLF ATHYHELTKL EGKLRGVRNF 750
NVSVEEREDD IIFLHKIVPG GSDRSYGIQV SKLAGLPYSI IERAKEILEA 800
LERDKAVKNE LEEAVSQFAF TQIDIFSSAK DALIEEIANC DPDNMTPLQA 850
LTYLYKLKEK AASLRSGVI 869
Length:869
Mass (Da):99,087
Last modified:June 1, 2002 - v1
Checksum:i74F6A4F5624A5882
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM24579.1.
RefSeqiNP_622975.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM24579; AAM24579; TTE1357.
GeneIDi997769.
KEGGitte:TTE1357.
PATRICi23897428. VBITheTen82880_1367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM24579.1 .
RefSeqi NP_622975.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8RA71.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273068.TTE1357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM24579 ; AAM24579 ; TTE1357 .
GeneIDi 997769.
KEGGi tte:TTE1357.
PATRICi 23897428. VBITheTen82880_1367.

Phylogenomic databases

eggNOGi COG0249.
HOGENOMi HOG000221406.
KOi K03555.
OMAi ASMRDGG.
OrthoDBi EOG6Q5NPV.

Family and domain databases

Gene3Di 3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00096. MutS.
InterProi IPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsi TIGR01070. mutS1. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiMUTS_THETN
AccessioniPrimary (citable) accession number: Q8RA71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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