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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi619 – 6268ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: UniProtKB-HAMAP
  3. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Synonyms:mutS2
Ordered Locus Names:TTE1357
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869DNA mismatch repair protein MutSPRO_0000115161Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE1357.

Structurei

3D structure databases

ProteinModelPortaliQ8RA71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiCLLLFRM.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8RA71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKMSVTPMM EQYLKIKEKY KDAILFFRLG DFYEMFYEDA EIAAKELEIA
60 70 80 90 100
LTGRDAGTEE RAPMAGVPYH AADFYIDKLV KKGYKVAICE QLEDPSKAKG
110 120 130 140 150
LVKRDVVRIY TPGTIINPES MDEKSNNYLV SVYREKDNYG ICAVDVTTGE
160 170 180 190 200
LYATEIKNCK NGKRIYDEIA KYSPSEIISN EEFLKNNKYI KVFKNNNCAV
210 220 230 240 250
NAYKPLNYEA SSELIEKQFD KKVEELELED KKFVIHSLGA LLSYLKELQK
260 270 280 290 300
TSLKHINKLT LYQDNSYMGL DSNAIRNLEI LESNRNKSKK GSLLGVLDRT
310 320 330 340 350
VTPMGGRLLK KWLEEPLIDK DEIEKRLDAV EELFNNYRER IELKELLNKV
360 370 380 390 400
YDLERLASKI VYQSVTPKDF ISIKLSLQNL PKIKNILSKF SSRLLKEIYE
410 420 430 440 450
KLDVLQDVYE LIDKSIKDDP SNQLKEGNII KDGYNEMVDK LRKASTEGKN
460 470 480 490 500
WIANLEADER EKTGIKNLRI GYNKVFGYYI EVTKSNIPQV PDRYIRKQTL
510 520 530 540 550
ANAERYVTPE LKEIEETILG AEEKLIELEY ELFNEIREKV ELQIVRIQNT
560 570 580 590 600
AKYIAIIDVL ISFAEVAETN KYVKPIVDYE DRIVIKEGRH PVVETISDEG
610 620 630 640 650
FVANDIDIGP ENPIMIITGP NMAGKSTYMR QVALIVLMAQ VGCFVPASYA
660 670 680 690 700
RIGIVDKIFT RVGASDDIFA GQSTFMVEMS EVANILHSAT SKSLIILDEV
710 720 730 740 750
GRGTSTYDGM SIAQAVIEYI HEKIKAKTLF ATHYHELTKL EGKLRGVRNF
760 770 780 790 800
NVSVEEREDD IIFLHKIVPG GSDRSYGIQV SKLAGLPYSI IERAKEILEA
810 820 830 840 850
LERDKAVKNE LEEAVSQFAF TQIDIFSSAK DALIEEIANC DPDNMTPLQA
860
LTYLYKLKEK AASLRSGVI
Length:869
Mass (Da):99,087
Last modified:June 1, 2002 - v1
Checksum:i74F6A4F5624A5882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM24579.1.
RefSeqiNP_622975.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM24579; AAM24579; TTE1357.
KEGGitte:TTE1357.
PATRICi23897428. VBITheTen82880_1367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM24579.1.
RefSeqiNP_622975.1. NC_003869.1.

3D structure databases

ProteinModelPortaliQ8RA71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273068.TTE1357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM24579; AAM24579; TTE1357.
KEGGitte:TTE1357.
PATRICi23897428. VBITheTen82880_1367.

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiCLLLFRM.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiMUTS_CALS4
AccessioniPrimary (citable) accession number: Q8RA71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.