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Q8RA71

- MUTS_THETN

UniProt

Q8RA71 - MUTS_THETN

Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi619 – 6268ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. damaged DNA binding Source: UniProtKB-HAMAP
    3. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutSUniRule annotation
    Gene namesi
    Name:mutSUniRule annotation
    Synonyms:mutS2
    Ordered Locus Names:TTE1357
    OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
    Taxonomic identifieri273068 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
    ProteomesiUP000000555: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 869869DNA mismatch repair protein MutSPRO_0000115161Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273068.TTE1357.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8RA71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0249.
    HOGENOMiHOG000221406.
    KOiK03555.
    OMAiASMRDGG.
    OrthoDBiEOG6Q5NPV.

    Family and domain databases

    Gene3Di3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00096. MutS.
    InterProiIPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsiTIGR01070. mutS1. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8RA71-1 [UniParc]FASTAAdd to Basket

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    MLKMSVTPMM EQYLKIKEKY KDAILFFRLG DFYEMFYEDA EIAAKELEIA    50
    LTGRDAGTEE RAPMAGVPYH AADFYIDKLV KKGYKVAICE QLEDPSKAKG 100
    LVKRDVVRIY TPGTIINPES MDEKSNNYLV SVYREKDNYG ICAVDVTTGE 150
    LYATEIKNCK NGKRIYDEIA KYSPSEIISN EEFLKNNKYI KVFKNNNCAV 200
    NAYKPLNYEA SSELIEKQFD KKVEELELED KKFVIHSLGA LLSYLKELQK 250
    TSLKHINKLT LYQDNSYMGL DSNAIRNLEI LESNRNKSKK GSLLGVLDRT 300
    VTPMGGRLLK KWLEEPLIDK DEIEKRLDAV EELFNNYRER IELKELLNKV 350
    YDLERLASKI VYQSVTPKDF ISIKLSLQNL PKIKNILSKF SSRLLKEIYE 400
    KLDVLQDVYE LIDKSIKDDP SNQLKEGNII KDGYNEMVDK LRKASTEGKN 450
    WIANLEADER EKTGIKNLRI GYNKVFGYYI EVTKSNIPQV PDRYIRKQTL 500
    ANAERYVTPE LKEIEETILG AEEKLIELEY ELFNEIREKV ELQIVRIQNT 550
    AKYIAIIDVL ISFAEVAETN KYVKPIVDYE DRIVIKEGRH PVVETISDEG 600
    FVANDIDIGP ENPIMIITGP NMAGKSTYMR QVALIVLMAQ VGCFVPASYA 650
    RIGIVDKIFT RVGASDDIFA GQSTFMVEMS EVANILHSAT SKSLIILDEV 700
    GRGTSTYDGM SIAQAVIEYI HEKIKAKTLF ATHYHELTKL EGKLRGVRNF 750
    NVSVEEREDD IIFLHKIVPG GSDRSYGIQV SKLAGLPYSI IERAKEILEA 800
    LERDKAVKNE LEEAVSQFAF TQIDIFSSAK DALIEEIANC DPDNMTPLQA 850
    LTYLYKLKEK AASLRSGVI 869
    Length:869
    Mass (Da):99,087
    Last modified:June 1, 2002 - v1
    Checksum:i74F6A4F5624A5882
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM24579.1.
    RefSeqiNP_622975.1. NC_003869.1.

    Genome annotation databases

    EnsemblBacteriaiAAM24579; AAM24579; TTE1357.
    GeneIDi997769.
    KEGGitte:TTE1357.
    PATRICi23897428. VBITheTen82880_1367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM24579.1 .
    RefSeqi NP_622975.1. NC_003869.1.

    3D structure databases

    ProteinModelPortali Q8RA71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273068.TTE1357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM24579 ; AAM24579 ; TTE1357 .
    GeneIDi 997769.
    KEGGi tte:TTE1357.
    PATRICi 23897428. VBITheTen82880_1367.

    Phylogenomic databases

    eggNOGi COG0249.
    HOGENOMi HOG000221406.
    KOi K03555.
    OMAi ASMRDGG.
    OrthoDBi EOG6Q5NPV.

    Family and domain databases

    Gene3Di 3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00096. MutS.
    InterProi IPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsi TIGR01070. mutS1. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

    Entry informationi

    Entry nameiMUTS_THETN
    AccessioniPrimary (citable) accession number: Q8RA71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3