Q8R9T6 (PKN1_THETN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase Sps1
EC=2.7.11.1

Gene names

Name:	sps1
Ordered Locus Names:	TTE1500

Organism

Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]

Taxonomic identifier

273068 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteraceae › Caldanaerobacter › Caldanaerobacter subterraneus › Caldanaerobacter subterraneus subsp. tengcongensis

Protein attributes

Sequence length	625 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 3 PASTA domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW penicillin binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 625	625	Probable serine/threonine-protein kinase Sps1		PRO_0000171246
Regions
	Domain	10 – 271	262	Protein kinase
	Domain	344 – 410	67	PASTA 1
	Domain	411 – 477	67	PASTA 2
	Domain	478 – 545	68	PASTA 3
	Nucleotide binding	16 – 24	9	ATP By similarity
Sites
	Active site	134	1	Proton acceptor By similarity
	Binding site	39	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R9T6 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 2F10C267A028347E	FASTA	625	69,850
	10 20 30 40 50 60 MIGRMLGNRY EILEKIGEGG MAKVYKAKCH LLNRIVAIKI LRPEFAADEN FVKKFKRESQ 70 80 90 100 110 120 AAASLSHPNI VGIYDVGQEG DIYYIVMEYV KGRTLKELIR ENGGPLEVKR AVEIASQVCR 130 140 150 160 170 180 ALDHAHKNKI IHRDIKPQNI LVTDEDVVKV TDFGIARAAN GATITYTGDV IGTAYYFSPE 190 200 210 220 230 240 QAKGSIVDER TDIYSLGIVL FEMLTGKVPF EGDSPISVAL KHIQEDILPP SRLNEKVPEE 250 260 270 280 290 300 LDKIVLKATQ KDPNLRYQTA SEFLKDLDTF LKNPKDLKFE EKDFEKTKVM PSREAEELKR 310 320 330 340 350 360 AALKREREKK RKEIRKKVGI VLLVLLLLAS LSYGTVYVLN NFFKVNDVVV PNVVGLSLSQ 370 380 390 400 410 420 ASKVLSEHNL KMEISEERYS DKPENTILEQ DPPQGALVKP GTTVYVVISK GRQMVIVPNV 430 440 450 460 470 480 IGRDYLEAKN VLENAGLKVN IIENYNEQYQ KGYVFDQNPR YGVQVEYGTT IDVYVSKGPK 490 500 510 520 530 540 PSIVPNVVNM NLDEAKASLE SAGLTLGKVI YKEADNVPEN TVLEQSVPPD TEVQKGSPID 550 560 570 580 590 600 LIVSKLPQNS LQQQTKNVII NLPNKDGPMK VEVYVIQDGQ KNLVYSGEHT SSDSPLTVPV 610 620 TAHKGKAVIE VDIDGQVYSR VEARF

References

[1]

"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008691 Genomic DNA. Translation: AAM24718.1.
RefSeq	NP_623114.1. NC_003869.1.
3D structure databases
ProteinModelPortal	Q8R9T6.
ModBase	Search...
Protein-protein interaction databases
STRING	273068.TTE1500.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM24718; AAM24718; TTE1500.
GeneID	997918.
KEGG	tte:TTE1500.
PATRIC	23897708. VBITheTen82880_1507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000037185.
KO	K08884.
OMA	GEGGMAK.
ProtClustDB	CLSK901279.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR005543. PASTA. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF03793. PASTA. 3 hits. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00740. PASTA. 3 hits. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51178. PASTA. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKN1_THETN

Accession

Primary (citable) accession number: Q8R9T6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program