Q8R924 (G6PI_THETN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	TTE1806

Organism

Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]

Taxonomic identifier

273068 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Caldanaerobacter

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180756
Sites
	Active site	291	1	Proton donor By similarity
	Active site	312	1	By similarity
	Active site	426	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R924 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 6C733BA742488F51	FASTA	451	50,871
	10 20 30 40 50 60 MKKLISFDYS KALPFIHPHE IEYMEKHAKL SLEMVLKANA QGNGFLGWVN LPRDYDRAEF 70 80 90 100 110 120 ERIKKAAHKI QSDSDVLVVI GIGGSYLGAR AAIEMLSHSF YNLLPKGKRN TPEIYFAGNS 130 140 150 160 170 180 ISSTYLKDLL ELIADKEVSI NVISKSGTTT EPAIAFRVFR DFMEKKYGKD KARSRIYVTT 190 200 210 220 230 240 DREKGALKKL ADSEGYETFV IPDDVGGRYS VLTAVGLLPI AVAGINIDEM MEGAYEASTV 250 260 270 280 290 300 YTKEDLSENI SMQYAILRNI LYRKGKAIEI LVNYEPRLHY FAEWWKQLFG ESEGKDQKGI 310 320 330 340 350 360 YPASVDFTTD LHSMGQFIQE GSRNIFETVL NVEKPAKDII INEDRDNIDG LNFLAGKTID 370 380 390 400 410 420 FVNKKAFEGT LLAHTDGGVP NLVVNIPEIT PFYFGNLVYF FEMACAISGY INGVNPFDQP 430 440 450 GVEAYKKNMF ALLGRPGFEK EREELERRLR G

References

[1]	"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008691 Genomic DNA. Translation: AAM24998.1.
RefSeq	NP_623394.1. NC_003869.1.
3D structure databases
ProteinModelPortal	Q8R924.
SMR	Q8R924. Positions 5-449.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	996986.
GenomeReviews	Gene locus TTE1806 in contig AE008691_GR.
KEGG	tte:TTE1806.
NMPDR	fig|273068.3.peg.1336.
PATRIC	23898361. VBITheTen82880_1818.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG615843.
OMA	GQGNDFL.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	TTEN273068:TTE1806-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_THETN

Accession

Primary (citable) accession number: Q8R924

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program