ID   GAL1_THETN              Reviewed;         390 AA.
AC   Q8R8R7;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Galactokinase;
DE            EC=2.7.1.6;
DE   AltName: Full=Galactose kinase;
GN   Name=galK; OrderedLocusNames=TTE1928;
OS   Thermoanaerobacter tengcongensis.
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteriaceae; Thermoanaerobacter.
OX   NCBI_TaxID=119072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   MEDLINE=21992816; PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J.,
RA   Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L.,
RA   Tan H., Chen R., Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + D-galactose = ADP + alpha-D-galactose 1-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
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DR   EMBL; AE013143; AAM25107.1; -; Genomic_DNA.
DR   RefSeq; NP_623503.1; -.
DR   GeneID; 997123; -.
DR   GenomeReviews; AE008691_GR; TTE1928.
DR   KEGG; tte:TTE1928; -.
DR   NMPDR; fig|273068.3.peg.1790; -.
DR   HOGENOM; Q8R8R7; -.
DR   OMA; Q8R8R7; CEITDIQ.
DR   BioCyc; TTEN273068:TTE1928-MON; -.
DR   BRENDA; 2.7.1.6; 276887.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004335; F:galactokinase activity; IEA:HAMAP.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00246; -; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_gal_bd.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR006206; Mev_galkinase.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Galactose metabolism; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    390       Galactokinase.
FT                                /FTId=PRO_0000184633.
FT   NP_BIND     120    130       ATP (Potential).
SQ   SEQUENCE   390 AA;  43749 MW;  CE70AB7110B5907D CRC64;
     MEIAVVEALE KFYGKSDREI RLFYSPGRVN LIGEHTDYNG GYVFPCALDF GTYAAIRKRD
     DKKVFMASLN FDLKVEVDLD SIFYDKEHDW ANYPKGVLKI LQEEGYEFSG FEIVFGGNIP
     VGAGLSSSAS IEMVTAVAVN EVFNLNIDRI NLVKLCQRAE NTFVGVNCGI MDQFAVGMGK
     KGHAILLKSD TLEYSYVPLN LEGYKILITN TNKKRGLLDS KYNERRSECE KALTYLKKAL
     PVKNLSEVTV ERFEEYKDLI PDEVLRKRAR HVITENKRVL DAVKALNDND IVKFGKLMIE
     SHNSLRNDFE VTGKELDTLV EEALKLKGVV GSRMTGAGFG GCTVSIVKED AVEEFIEVVT
     RNYTQKIGYA PTVYVTGVGE GAGEVEYLRR
//