Reviewed, UniProtKB/Swiss-Prot Q8R8R7 (GAL1_THETN)

Names and origin

Protein names

Recommended name:
    Galactokinase
    EC=2.7.1.6
Alternative name(s):
    Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	TTE1928

Organism

Thermoanaerobacter tengcongensis [Complete proteome] [HAMAP]

Taxonomic identifier

119072 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate phosphorylation Inferred from electronic annotation. Source: InterPro galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Galactokinase HAMAP MF_00246		PRO_0000184633
Regions
	Nucleotide binding	120 – 130	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8R8R7-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: CE70AB7110B5907D	FASTA	390	43,749
	10 20 30 40 50 60 MEIAVVEALE KFYGKSDREI RLFYSPGRVN LIGEHTDYNG GYVFPCALDF GTYAAIRKRD 70 80 90 100 110 120 DKKVFMASLN FDLKVEVDLD SIFYDKEHDW ANYPKGVLKI LQEEGYEFSG FEIVFGGNIP 130 140 150 160 170 180 VGAGLSSSAS IEMVTAVAVN EVFNLNIDRI NLVKLCQRAE NTFVGVNCGI MDQFAVGMGK 190 200 210 220 230 240 KGHAILLKSD TLEYSYVPLN LEGYKILITN TNKKRGLLDS KYNERRSECE KALTYLKKAL 250 260 270 280 290 300 PVKNLSEVTV ERFEEYKDLI PDEVLRKRAR HVITENKRVL DAVKALNDND IVKFGKLMIE 310 320 330 340 350 360 SHNSLRNDFE VTGKELDTLV EEALKLKGVV GSRMTGAGFG GCTVSIVKED AVEEFIEVVT 370 380 390 RNYTQKIGYA PTVYVTGVGE GAGEVEYLRR

References

[1]

"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013143 Genomic DNA. Translation: AAM25107.1.
RefSeq	NP_623503.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	997123.
GenomeReviews	Gene locus TTE1928 in contig AE008691_GR.
KEGG	tte:TTE1928.
NMPDR	fig|273068.3.peg.1790.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8R8R7.
OMA	Q8R8R7. CEITDIQ.
Enzyme and pathway databases
BioCyc	TTEN273068:TTE1928-MON.
BRENDA	2.7.1.6. 276887.
Family and domain databases
HAMAP	MF_00246. [Tree]
InterPro	IPR000705. Galactokinase. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal_bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_THETN

Accession

Primary (citable) accession number: Q8R8R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)