Reviewed, UniProtKB/Swiss-Prot Q8R860 (ALR2_THETN)

Names and origin

Protein names

Recommended name:
    Alanine racemase 2
    EC=5.1.1.1

Gene names

Name:	alr2
Ordered Locus Names:	TTE2168

Organism

Thermoanaerobacter tengcongensis [Complete proteome] [HAMAP]

Taxonomic identifier

119072 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Thermoanaerobacter

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Alanine racemase 2 HAMAP MF_01201		PRO_0000114589
Sites
	Active site	39	1	Proton acceptor; specific for D-alanine By similarity
	Active site	267	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	39	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R860-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 7C55CCEFF847BEEF	FASTA	388	43,755
	10 20 30 40 50 60 MFDEIRPTRV EVNLDSIVHN FREIKRVVGD RVKVMGVVKA NAYGHGAYHV AKALVENGVD 70 80 90 100 110 120 YLAVATVEEA LELRSYGITA PVLILGYTPL SQAGEAVEKD VTFTAFDLKY VKELGEIASR 130 140 150 160 170 180 KGKKAKIHVK IDTGMGRIGY TDFDLAEREI EEMSKLEGIE LEGIFSHFAT SDEKDKDYAR 190 200 210 220 230 240 EQFERFADML KRLEKRGVNI TLKHIANSGA ITDLNYAYLD MVRPGITLYG SYPSNDVNKI 250 260 270 280 290 300 LDLRPAMNFK TKIVYIKEVP ENTSISYGRT FITKRPSKIA TLPIGYADGL NRLLSNNHEV 310 320 330 340 350 360 LVRGKYVPIV GRVCMDQTMI DVTEVEGVEV GDEVVIFGEQ EGKRITADDI AKKLRTIPHE 370 380 VYCGISRRVP RIYIYRGEVF DVKNYLKI

References

[1]

"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008691 Genomic DNA. Translation: AAM25327.1.
RefSeq	NP_623723.1.
3D structure databases
HSSP	HSSP built from PDB template 1BD0 based on UniProtKB P10724.
ModBase	Search...
Genome annotation databases
GeneID	997486.
GenomeReviews	Gene locus TTE2168 in contig AE008691_GR.
KEGG	tte:TTE2168.
NMPDR	fig|273068.3.peg.2311.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8R860.
OMA	VCMDQTM.
Enzyme and pathway databases
BioCyc	TTEN273068:TTE2168-MON.
BRENDA	5.1.1.1. 276887.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR2_THETN

Accession

Primary (citable) accession number: Q8R860

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	June 1, 2002
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)