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Q8R841

- GLMS_THETN

UniProt

Q8R841 - GLMS_THETN

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, TTE2190
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei603 – 6031For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:TTE2190
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135403Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE2190.

Structurei

3D structure databases

ProteinModelPortaliQ8R841.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini285 – 424140SIS 1
Add
BLAST
Domaini453 – 598146SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R841-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGD KQATPILLEG LTRLEYRGYD SAGIAILHNG NINIKKAKGR    50
LNVLRELVEK DYMEGTIGIG HTRWATHGEP SDTNSHPHLS QSGLIAVVHN 100
GIIENYLPLK KWLIEEGYNF ISETDTEVVA NLLEYYYNGD IVEALRKVLD 150
RIEGSYALGV LCKDNPDMIV AARKEAPLIV GIGNGENFIA SDIPAILKYT 200
RNVYFLDDHE IAIIKKDSVE FIDVFGRKIG KSLFEVKWDV EAAEKGGYEH 250
FMIKEIHEQP AAIKDTLRGR IINDSQIVLD NINITKEDLE KIEKIFIVAC 300
GTAYHAGVVG KYVIESFARI PVEVDVASEF RYRNPIVNER ILTIVISQSG 350
ETADTIAALK EAKRKGSRVI AITNVVGSSV SREADEVLYT WAGPEIAVAS 400
TKAYTTQLIA LYLIALDFAL KKGTMSSTKV VEIISELKKL PDKVQYLLDN 450
KEVIQKFASE HYNVKDVFYI GRGLDYAVAM EGSLKLKEIS YIHSEAYPAG 500
ELKHGTLALV EEGTLIIALA TQDDLFEKML SNIKEVKARG GYVVAFAKQG 550
NLQLEGVVDK VIYIPDTLKE LTPVLTVVPL QLLAYYMAVE KGCDVDKPRN 600
LAKSVTVE 608
Length:608
Mass (Da):67,445
Last modified:January 23, 2007 - v3
Checksum:i4389A3938DCE8FC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM25347.1.
RefSeqiNP_623743.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM25347; AAM25347; TTE2190.
GeneIDi997509.
KEGGitte:TTE2190.
PATRICi23899111. VBITheTen82880_2192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM25347.1 .
RefSeqi NP_623743.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8R841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE2190.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM25347 ; AAM25347 ; TTE2190 .
GeneIDi 997509.
KEGGi tte:TTE2190.
PATRICi 23899111. VBITheTen82880_2192.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiGLMS_THETN
AccessioniPrimary (citable) accession number: Q8R841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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